Abstracts tagged "Cytokines and vasculitis"

Abstract Number: 1766 • 2019 ACR/ARP Annual Meeting
GM-CSF Is a Pro-Inflammatory Cytokine in Experimental Vasculitis of Medium and Large Arteries
Ryu Watanabe ¹, Hui Zhang ², Toshihisa Maeda ³, Mitsuhiro Akiyama ², Rohan Gandhi ⁴, John Paolini ⁵, Gerald Berry ¹ and Cornelia Weyand², ¹Stanford University, Stanford, ²Stanford University, Stanford, CA, ³Matsubara Mayflower Hospital, Kobe, Japan, ⁴Kiniska Pharmaceuticals, San Diego, ⁵Kiniska Pharmaceuticals, Lexington, MA
Background/Purpose: Giant Cell Arteritis (GCA) is a granulomatous vasculitis with tissue tropism for medium and large arteries. Macrophages are a key cellular component of the…
Abstract Number: 874 • 2016 ACR/ARHP Annual Meeting
Expression and Function of IL-12/23 Related Cytokine Subunits (p35, p40 and p19) in Giant-Cell Arteritis Lesions. Potential Role of p40 in Promoting Th1 -Mediated Pathways
Georgina Espígol-Frigolé¹, Ester Planas-Rigol¹, Ester Lozano², Marc Corbera-Bellalta², Nekane Terrades-Garcia², Sergio Prieto-González¹, Ana García-Martínez³, Jose Hernández-Rodríguez² and Maria C. Cid⁴, ¹Department of Autoimmune and Systemic Diseases, Hospital Clínic. University of Barcelona. IDIBAPS, Barcelona, Spain, ²Vasculitis Research Unit. Department of Autoimmune Diseases, Hospital Clínic. University of Barcelona. IDIBAPS, Barcelona, Spain, ³Emergeny Department, Hospital Clínic. University of Barcelona. IDIBAPS, Barcelona, Spain, ⁴Autoimmune and Systemic Diseases, Hospital Clínic. University of Barcelona. IDIBAPS, Barcelona, Spain
Background/Purpose: GCA has been considered a Th1-mediated disease. In recent years it has become apparent that Th17-mediated mechanisms may also play a role in GCA…