ACR Meeting Abstracts

ACR Meeting Abstracts

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Abstracts tagged "Cytokines and vasculitis"

  • Abstract Number: 1766 • 2019 ACR/ARP Annual Meeting

    GM-CSF Is a Pro-Inflammatory Cytokine in Experimental Vasculitis of Medium and Large Arteries

    Ryu Watanabe 1, Hui Zhang 2, Toshihisa Maeda 3, Mitsuhiro Akiyama 2, Rohan Gandhi 4, John Paolini 5, Gerald Berry 1 and Cornelia Weyand2, 1Stanford University, Stanford, 2Stanford University, Stanford, CA, 3Matsubara Mayflower Hospital, Kobe, Japan, 4Kiniska Pharmaceuticals, San Diego, 5Kiniska Pharmaceuticals, Lexington, MA

    Background/Purpose: Giant Cell Arteritis (GCA) is a granulomatous vasculitis with tissue tropism for medium and large arteries. Macrophages are a key cellular component of the…
  • Abstract Number: 874 • 2016 ACR/ARHP Annual Meeting

    Expression and Function of IL-12/23 Related Cytokine Subunits (p35, p40 and p19)  in Giant-Cell Arteritis Lesions.  Potential Role of p40 in Promoting Th1 -Mediated Pathways

    Georgina Espígol-Frigolé1, Ester Planas-Rigol1, Ester Lozano2, Marc Corbera-Bellalta2, Nekane Terrades-Garcia2, Sergio Prieto-González1, Ana García-Martínez3, Jose Hernández-Rodríguez2 and Maria C. Cid4, 1Department of Autoimmune and Systemic Diseases, Hospital Clínic. University of Barcelona. IDIBAPS, Barcelona, Spain, 2Vasculitis Research Unit. Department of Autoimmune Diseases, Hospital Clínic. University of Barcelona. IDIBAPS, Barcelona, Spain, 3Emergeny Department, Hospital Clínic. University of Barcelona. IDIBAPS, Barcelona, Spain, 4Autoimmune and Systemic Diseases, Hospital Clínic. University of Barcelona. IDIBAPS, Barcelona, Spain

    Background/Purpose:  GCA has been considered a Th1-mediated disease. In recent years it has become apparent that Th17-mediated mechanisms may also play a role in GCA…
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