Abstracts tagged "cytokines and transcription factor"

Abstract Number: 95 • ACR/ARP Annual Meeting 2019
IL-21-mediated Suppression of STAT5 Phosphorylation Underlies Treg Depletion and Dysfunction in SLE
Hiroshi Kato¹ and Andras Perl ¹, ¹SUNY Upstate Medical University, Syracuse, NY
Background/Purpose: IL-21 activates mechanistic target of rapamycin (mTOR) complexes 1 and 2 which in turn block regulatory T (Treg)-cell differentiation and function in patients with…
Abstract Number: 1910 • ACR/ARHP Annual Meeting 2016
IL-21 Inhibits Treg Differentiation and Function in SLE By Modulating GATA-3 and CTLA-4
Hiroshi Kato¹ and Andras Perl², ¹Division of Rheumatology/Internal Medicine, SUNY Upstate Medical University, Syracuse, NY, ²Department of Medicine, SUNY Upstate Medical University, Syracuse, NY
Background/Purpose: Studies indicate quantitative and qualitative Treg insufficiencies underlying the dysregulated immune response in SLE. However, it is unknown what mechanisms drive the Treg dysfunction…