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Abstracts tagged "cytokines and T cells"

  • Abstract Number: 2042 • ACR/ARP Annual Meeting 2019

    Intestinal Microbiota Alters Th1/Th17 Balance but Is Dispensable for the Development of Systemic Autoimmune Disease in BXD2 Mice

    Huixian Hong1, Qi Wu 1, PingAr Yang 1, Bao Luo 2, Alex Essman 2, Oluwagbemiga Ojo 2, Michael R. Crowley 3, David K. Crossman 3, Casey D. Morrow 4, Jeremy B. Foote 5, Trenton R. Schoeb 6, Charles O. Elson 7, Hui-Chen Hsu 8 and John D. Mountz 9, 1Division of Clinical Immunology and Rheumatology, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, 2Division of Clinical Immunology and Rheumatology, Department of Medicine, University of Alabama at Birmingham, Birmingham, 3Department of Genetics, University of Alabama at Birmingham, Birmingham, 4Department of Cell, Developmental, and Integrative Biology, University of Alabama at Birmingham, Birmingham, 5Department of Microbiology, University of Alabama at Birmingham, Birmingham, 6Department of Genetics, Animal Resources Program, University of Alabama at Birmingham, Birmingham, 7Department of Medicine, University of Alabama at Birmingham, Birmingham, 81Division of Clinical Immunology and Rheumatology, Department of Medicine, University of Alabama at Birmingham, Birmingham, 9Division of Clinical Immunology and Rheumatology, Department of Medicine, University of Alabama at Birmingham & University of Alabama at Birmingham and Birmingham VA Medical center, Birmingham

    Background/Purpose: Intestinal microbiota dysbiosis has been implicated in the pathogenesis of autoimmune disease.  How the microbiota affects the peripheral immune system leading to the development…

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