Abstracts tagged "cytokines and systemic lupus erythematosus (SLE)"

Abstract Number: 2330 • 2012 ACR/ARHP Annual Meeting
Mucosal-Associated Invariant T Cells Are Inactivated by IFNα and Reduced in Systemic Lupus Erythematosus
Asako Chiba¹, Naoto Tamura², Ran Matsudaira³, Takashi Yamamura¹, Yoshinari Takasaki² and Sachiko Miyake¹, ¹Department of Immunology, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Tokyo, Japan, ²Internal Medicine and Rheumatology, Juntendo University School of Medicine, Tokyo, Japan, ³Department of Internal Medicine and Rheumatology, Juntendo University School of Medicine, Tokyo, Japan
Background/Purpose: Mucosal-associated invariant T (MAIT) cells are a subset of innate-like lymphocytes which are restricted by the MHC-related molecule-1 (MR1) and express an invariant TCRα…
Abstract Number: 1439 • 2012 ACR/ARHP Annual Meeting
CTL-Promoting Effects of IL-21 Results in B Cell Elimination and Disease Improvement in a Murine Model of Lupus
Vinh Nguyen¹, Daniel Veizaga-Udaeta², Horea Rus³ and Violeta Rus⁴, ¹Medicine, University of Maryland School of Medicine, Baltimore, MD, ²University of Maryland at Baltimore County, MD, ³Neurology, University of Maryland School of Medicine and Veteran Affairs Medical Center, Baltimore, MD, ⁴Medicine, University of Maryland School of Medicine and Veteran Affairs Medical Center, Baltimore, MD
Background/Purpose: IL-21 is a member of the type I cytokine family with pleiotropic activities. IL-21 enhances CD8 T cells maturation into cytotoxic T lymphocytes (CTL),…
Abstract Number: 682 • 2012 ACR/ARHP Annual Meeting
IL-12p70 Levels Play a Role in Damage Accrual in SLE Patients
Eoghan M. McCarthy¹, Ruth Lee², Joan Ni Gabhann³, Siobhan Smith³, Michele Doran⁴, Gaye Cunnane⁵, Donough G. Howard², Paul G. O'Connell¹, Caroline Jefferies³ and Grainne M. Kearns⁶, ¹Rheumatology, Beaumont Hospital, Dublin, Ireland, ²Rheumatology, Beaumont Hospital, Dublin 9, Ireland, ³Molecular and Cellular Therapeutics, Royal College of Surgeons in Ireland, Dublin, Ireland, ⁴Rheumatology Dept, St James's Hospital, Dublin, Ireland, ⁵Dept of Rheumatology, St. James's Hospital, Dublin, Ireland, ⁶Rheumatology Department, Beaumont Hospital, Dublin, Ireland
Background/Purpose: Whilst the role of cytokines in promoting disease activity in SLE is well established, the relationship between cytokines in those who sustain irreversible damage…
Abstract Number: 665 • 2012 ACR/ARHP Annual Meeting
Cytokines and Their Relation to Autoantibodies Before Disease Onset in Systemic Lupus Erythematosus
Catharina Eriksson¹ and Solbritt Rantapää Dahlqvist², ¹Department of Clinical Immunology/clinical microbiology, Umeå, Sweden, ²Department of Public Health and Clinical Medicine/Rheumatology, Umeå University Hospital, Umeå, Sweden
Background/Purpose: Cytokines and autoantibodies are involved in the pathogenesis of systemic lupus erythematosus (SLE). The presence of autoantibodies preceding disease onset by years has been…

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