Abstract Number: 1081 • 2018 ACR/ARHP Annual Meeting
Associations between Daily Alcohol Intake and SLE-Related Cytokines and Chemokines U.S. Female Nurses without SLE
Background/Purpose: Low or no alcohol intake (0-5 gm/day or <0.5 drinks/day) has been associated with increased SLE risk among women. Several cytokines and chemokines are…Abstract Number: 1693 • 2018 ACR/ARHP Annual Meeting
Innate, Adaptive, and TNF-Superfamily Immune Pathways Inform a Lupus Disease Activity Immune Index That Characterizes Disease Activity in SLE
Background/Purpose: Systemic lupus erythematosus (SLE) is a complex autoimmune disease marked by immune dysregulation. A comprehensive but cost-effective tool to track relevant mediators of altered…Abstract Number: 1743 • 2017 ACR/ARHP Annual Meeting
Serine Arginine/Rich Splicing Factor 1 (SRSF1) Increases IL-2 Production in T Cells By Increasing the Expression of NFAT and c-Fos
Background/Purpose: T cells from patients with systemic lupus erythematosus (SLE) produce insufficient amounts of the vital cytokine IL-2, and the molecular mechanisms leading to this…Abstract Number: 1776 • 2016 ACR/ARHP Annual Meeting
Analysis of Progressive Brain and Corpus Callosum Atrophy and Association with Th1 and Th2 Cytokines in Systemic Lupus Erythematosus
Background/Purpose: The pathophysiology of brain damage SLE is complex. The aim of this study was to determine brain atrophy progression and the association with Th1…Abstract Number: 2818 • 2016 ACR/ARHP Annual Meeting
High Sensitivity Multiplex ELISA Reveals Cytokine Expression Heterogeneity in Active SLE
Background/Purpose: Patients with SLE have a broad clinical and immunological phenotype in which multiple immune pathways may be sequentially or simultaneously activated. No reliable biomarkers…Abstract Number: 2835 • 2016 ACR/ARHP Annual Meeting
Longitudinal Analysis of Th1 and Th2 Cytokines in Systemic Lupus Erythematosus
Background/Purpose: While autoantibodies production and immune complex deposition are cornered as hallmark features of systemic lupus erythematosus (SLE), there is growing evidence to propose the…Abstract Number: 2935 • 2016 ACR/ARHP Annual Meeting
Activation Status of Mucosal-Associated Invariant T Cells Sensitively Reflects Disease Activity of Systemic Lupus Erythematosus
Background/Purpose: Mucosal-associated invariant T (MAIT) cells are innate-like lymphocytes that express a semi-invariant TCRα chain: Vα7.2-Jα33 in humans and Vα19-Jα33 in mice. MAIT cells are…Abstract Number: 1829 • 2015 ACR/ARHP Annual Meeting
Heart Rate Variability Is Associated with SLE Flare and with TNF- and IFN-Mediated Signaling
Background/Purpose: Decreased heart rate variability (HRV), associated with adverse outcomes in cardiovascular diseases, is frequently seen in patients with SLE. The LF/HF ratio, a HRV…Abstract Number: 1855 • 2015 ACR/ARHP Annual Meeting
Systemic Lupus Erythematosus Exosomes Contain Distinct RNA Transcripts That Differentiate Disease Activity and Modulate Cellular Function
Background/Purpose: Systemic lupus erythematosus (SLE) is a complex autoimmune disease involving multiple organ systems and periods of waxing and waning disease activity. The lack of…Abstract Number: 2066 • 2015 ACR/ARHP Annual Meeting
Elevated Innate, Adaptive, and TNF-Superfamily Soluble Inflammatory Mediators Mark Impending Disease Flare, While Regulatory Mediators Distinguish Lack of Impending Disease Flare in African-American SLE Patients with Active Disease
Background/Purpose: SLE is a multifaceted disease characterized by immune dysregulation and varied disease activity. Identifying mechanistic mediators of altered disease activity would help prevent damage…Abstract Number: 3156 • 2015 ACR/ARHP Annual Meeting
IL17 Promotes Development of Autoreactive Early Stage B Cells in Distinct Regions of the Spleen Follicle
Background/Purpose: The early stage transitional B cell has been shown to be the key peripheral B-cell tolerance control point defect in SLE patients. Anti-RNP Abs can…Abstract Number: 2734 • 2014 ACR/ARHP Annual Meeting
B55β Regulates T Cell Survival through the Modulation of AKT during Cytokine Deprivation
Background/Purpose . The abundance of cytokines controls the length of immune responses through poorly defined mechanisms. B55β is a molecule that triggers apoptosis in activated…Abstract Number: 1944 • 2014 ACR/ARHP Annual Meeting
Targeting CD22 with Epratuzumab Impacts Cytokine Production By B Cells
Background/Purpose CD22 is a negative co-receptor of the B-cell receptor (BCR) and, when targeted by epratuzumab, partially inhibits BCR signaling, for example by reducing Syk…Abstract Number: 1942 • 2014 ACR/ARHP Annual Meeting
Regulation of the Responses of Human B Cell Subsets to Innate Immune Signals By Epratuzumab, a Humanized Monoclonal Antibody Targeting CD22
Background/Purpose The B cell-associated receptor, CD22, functions to regulate adhesion and signaling through both the B cell receptor (BCR) and Toll-like receptors (TLRs) expressed in…Abstract Number: 1602 • 2013 ACR/ARHP Annual Meeting
Autoantibodies, Cytokines and Chemokines In Serum and Cerebrospinal Fluid Of SLE Patients With Cognitive Dysfunction
Background/Purpose: The nature and pathogenesis and cognitive dysfunction (CD) in patients with SLE is unkown.To determine the presence and levels of autoantibodies, cytokines and chemokines…
ACR Meeting Abstracts