Abstracts tagged "cytokines and spondylarthritis"

Abstract Number: 1377 • ACR/ARHP Annual Meeting 2015
IL-22 Drives the Proliferation and Differentiation of Human Bone Marrow Mesenchymal Stem Cells (MSCs); A Novel Pathway That May Contribute to Aberrant New Bone Formation in Human Spa and Beyond
Yasser El-Sherbiny¹, Ahmed Elzayadi², Evangelos M. Fragkakis¹, Richard Cuthbert¹, Thomas Baboolal³, Elena Jones¹ and Dennis McGonagle¹, ¹Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, United Kingdom, ²Obstetrics and Gynaecology, Mansoura University, Egypt, MD, MSc., Mansoura, Egypt, ³PhD, Leeds, United Kingdom
Background/Purpose: The human spondyloarthropathies (SpA) are associated with single nucleotide polymorphisms (SNPs) in the IL-23 pathway and IL-23/17 axis therapy is effective in SpA. The…