Abstracts tagged "cytokines and signal transduction"

Abstract Number: 969 • 2017 ACR/ARHP Annual Meeting
Modulation of Cartilage Degradation Biomarkers Reflect the Activation and Inhibition of Pro-Inflammatory Cytokine Signaling in an Ex Vivo Model of Bovine Cartilage
Cecilie F. Kjelgaard-Petersen^1,2, Neha Sharma^1,3, Ashref Kayed^4,5, Britt Christensen¹, Morten Karsdal⁶, Anne-C. Bay-Jensen⁷ and Christian S. Thudium¹, ¹Biomarkers and Research, Nordic Bioscience, Herlev, Denmark, ²Bioengineering, Technical University of Denmark, Kgs. Lyngby, Denmark, ³Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark, ⁴Research and Biomarkers, Nordic Bioscience, Herlev, Denmark, ⁵Biomolecular Sciences, University of Copenhagen, Copenhagen, Denmark, ⁶Biomarkers and Reseacrh, Nordic Bioscience, Herlev, Denmark, ⁷Biomarkers and Reseach, Nordic Bioscience, Herlev, Denmark
Background/Purpose: Several inflammatory cytokines and intracellular signaling pathways have been targeted in drug development with varying clinical results. Improved understanding of the intracellular signaling’s modulation…
Abstract Number: 2322 • 2012 ACR/ARHP Annual Meeting
Dynamic Regulation of T Follicular Helper Cell Differentiation Through STAT Signaling
Shingo Nakayamada¹, Yuka Kanno², Golnaz Vahedi², John J. O'Shea² and Yoshiya Tanaka¹, ¹First Department of Internal Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan, ²National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH, Bethesda, MD
Background/Purpose: T follicular helper (Tfh) cells are a new subset of T cells that regulate B cell function and exert an important role in the…

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