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Abstracts tagged "cytokines and rheumatoid arthritis (RA)"

  • Abstract Number: 1357 • 2017 ACR/ARHP Annual Meeting

    Anti-Cyclic Citrullinated Peptide Antibody Positive Rheumatoid Arthritis Patients with Comorbid Post-Traumatic Stress Disorder Have Higher Serum Cytokine Expression

    Bryant R. England1, Harlan Sayles2, Geoffrey M. Thiele2, Kaleb Michaud2, Jeremy Sokolove3, Grant Cannon4, Andreas Reimold5, Gail S. Kerr6, Liron Caplan7, Joshua Baker8 and Ted R. Mikuls9, 1Division of Rheumatology & Immunology, Department of Internal Medicine, Nebraska-Western IA VA Health Care System & University of Nebraska Medical Center, Omaha, NE, 2University of Nebraska Medical Center, Omaha, NE, 3Division of Immunology and Rheumatology, Stanford University Medical Center, Mountain View, CA, 4Salt Lake City VA Medical Center and University of Utah, Salt Lake City, UT, 5Hospital of Southern Norway, Kristiansand, Norway, 6VAMC, Georgetown University, Washington, DC, 7Division of Rheumatology, University of Colorado School of Medicine, Aurora, CO, 8Rheumatology, University of Pennsylvania, Philadelphia, PA, 9Internal Medicine, Division of Rheumatology, University of Nebraska Medical Center, Omaha, NE

    Background/Purpose: We have previously shown that rheumatoid arthritis (RA) patients with Post-Traumatic Stress Disorder (PTSD) have higher disease activity measures, due primarily to patient reported…
  • Abstract Number: 1747 • 2017 ACR/ARHP Annual Meeting

    Human C-C Chemokine Receptor-6 (CCR6)+ Th Memory Cells, Including Th17 and Th17.1 Cells, Change into Anti-Inflammatory Cells with Regulatory Capacity upon Exposure to Vitamin D

    Wendy Dankers1, Nadine Davelaar2, Jan Piet van Hamburg3, Patrick Asmawidjaja2, Hoyan Wen2, Johannes van Leeuwen4, Edgar Colin5 and Erik Lubberts2, 1Rheumatology, Erasmus MC, University Medical Center, Rotterdam, Netherlands, 2Rheumatology and Immunology, Erasmus MC, University Medical Center, Rotterdam, Netherlands, 3Rheumatology, Erasmus MC, Rotterdam, Netherlands, 4Internal Medicine, Erasmus MC, University Medical Center, Rotterdam, Netherlands, 5ZGT Almelo, Deventer, Netherlands

    Background/Purpose: Autoimmune diseases such as RA are driven by an aberrantly activated immune system and an imbalance between pro- and anti-inflammatory cells, resulting in tissue…
  • Abstract Number: 2354 • 2017 ACR/ARHP Annual Meeting

    Inflammatory Markers in Relation to Risk Factors for Cardiovascular Disease in the Pre-Symptomatic Phase of Rheumatoid Arthritis

    Heidi Kokkonen1, Linda Johansson2, Hans Stenlund3 and Solbritt Rantapaa-Dahlqvist4, 1Public Health and Clinical Medicine/ Rheumatology, Umeå University, Umeå, Sweden, 2Public Health and Clinical Medicine/Rheumatology, Umeå University, Umeå, Sweden, 32Department of Public Health and Clinical Medicine, Epidemiology and Global Health, Umeå University, Umeå, Sweden, 4Dept of Public Health and Clinical Medicine/Rheumatology, Umeå University, Sweden, Umeå, Sweden

    Background/Purpose: Individuals who later developed rheumatoid arthritis (RA) have increased levels and frequencies of risk factors for cardiovascular disease (CVD), years before onset of RA.…
  • Abstract Number: 1567 • 2016 ACR/ARHP Annual Meeting

    A Functional Genomic Screen of Rheumatoid Arthritis Risk Genes in Primary Human T Cells Reveals DDX6 As a Negative Modulator of Cytokine Expression

    Rumey Ishizawar1, Chantel Lester2, Jing Cui3, John Doench4, Robert Plenge5 and Michael Brenner6, 1Division of Rheumatology, Allergy, and Immunology and Thurston Arthritis Research Center, University of North Carolina, Chapel Hill, NC, 2Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Boston, MA, 3Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, 4Broad Institute of MIT and Harvard, Cambridge, MA, 5Genetics & Pharmacogenomics, Merck Research Laboratories, Merck & Co., Boston, MA, 6Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital and Harvard Medical School, Boston, MA

    Background/Purpose:  In rheumatoid arthritis (RA), genome-wide association studies have identified over 100 risk alleles. A major challenge is identifying causal genes in RA risk loci. As…
  • Abstract Number: 1916 • 2016 ACR/ARHP Annual Meeting

    Heightened MAIT Cell Sensitivity to MR1 Ligands Could Impact Control of Dysbiosis in Patients with Rheumatoid Arthritis and Ankylosing Spondylitis

    Diahann Jansen1, Elizabeth Klinken1, Hendrik Nel2, Soi Cheng Law2, Helen Benham3,4,5, Lisa Cummins6, Matthew Brown7, Tony Kenna2, Ligong Liu8, David Fairlie8, Jamie Rossjohn9,10,11, Mark Morrison3, Ranjeny Thomas3, Paraic O Cuiv1, James McCluskey12 and Alexandra Corbett12, 1The University of Queensland Diamantina Institute, Translational Research Institute, Woolloongabba, Australia, 2The University of Queensland Diamantina Institute, Translational Research Institute, Brisbane, Australia, 3Translational Research Institute, The University of Queensland Diamantina Institute, Woolloongabba, Australia, 4University of Queensland School of Medicine, Brisbane, Australia, 5Rheumatology, Princess Alexandra Hospital, Woolloongabba, Australia, 6Princess Alexandra Hospital, Woolloongabba, Australia, 7Queensland University of Technology, Brisbane, Australia, 8Institute for Molecular Bioscience, University of Queensland, Brisbane, Australia, 9Infection and Immunity Program, Biomedicine Discovery Institute and Department of Biochemistry and Molecular Biology, Monash University, Clayton, Australia, 10Institute of Infection and Immunity, Cardiff University School of Medicine, Cardiff, United Kingdom, 11Australian Research Council Centre of Excellence in Advanced Molecular Imaging, Monash University, Clayton, Australia, 12Department of Microbiology & Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne, Parkville, Australia

    Background/Purpose: Mucosal associated invariant T (MAIT) cells are an innate-like lymphocyte population predominant at mucosal sites, which express a semi-invariant T cell receptor restricted to…
  • Abstract Number: 2116 • 2016 ACR/ARHP Annual Meeting

    Cytokines Inhibition Modulates Activation and Homing Receptor of Different Peripheral Memory B Cell Subsets in RA

    Zafar Mahmood1, Marc Schmalzing2, Michael Gernert3, Thomas Dörner4 and Hans-Peter Tony3, 1Department of Medicine II, Rheumatology/Clinical Immunology, University of Würzburg, Würzburg, Germany, 2Rheumatology/Clinical Immunology, Medical Clinic II, University Clinic Wuerzburg, Würzburg, Germany, 3Rheumatology/Immunology, Medical Clinic II, University Clinic Wuerzburg, Würzburg, Germany, 4Charité - Universitätsmedizin Berlin, Berlin, Germany

    Background/Purpose: With the advent of B cell targeted therapies the modulation of memory B cells seems to be a prime target. Human peripheral memory B…
  • Abstract Number: 2619 • 2016 ACR/ARHP Annual Meeting

    Sustained Suppression of Peripheral Biomarkers By Mavrilimumab but Not Golimumab in Anti-Tumor Necrosis Factor-Inadequate Responders: An Exploratory Analysis in the Phase IIb Earth Explorer 2 Clinical Trial

    Xiang Guo1, Shiliang Wang1, Anne C. Bay-Jensen2, Morten Asser Karsdal2, A Godwood3, Marius Albulescu3, D Close3, Patricia C. Ryan1, Lorin Roskos4 and Wendy White1, 1Translational Sciences, MedImmune, LLC, Gaithersburg, MD, 2Rheumatology, Nordic Bioscience, Herlev, Denmark, 3MedImmune, Cambridge, United Kingdom, 4MedImmune, LLC, Mountain View, CA

    Background/Purpose: Treatment of rheumatoid arthritis (RA) patients by anti-tumour necrosis factors (anti-TNFs), such as golimumab, has improved patient outcomes. However, unmet therapeutic needs exist for…
  • Abstract Number: 3152 • 2015 ACR/ARHP Annual Meeting

    The IL-21 Signaling Pathway Is Enhanced in RA B Cells and Has the Potential to Alter Development and Cytokine Production in RA B Cells

    Jane H. Buckner1 and Elizabeth Samuelson2, 1Benaroya Research Institute at Virginia Mason, Seattle, WA, 2Translational Research, Benaroya Research Institute at Virginia Mason, Seattle, WA

    Background/Purpose: B cells have been implicated in the development of rheumatoid arthritis (RA) based on their production of autoantibodies and cytokines as well as the…
  • Abstract Number: 530 • 2015 ACR/ARHP Annual Meeting

    Immunomodulation of Naïve RA Patients PBMCs with a Multi-Epitope Peptide Derived from Citrullinated Autoantigens

    Smadar Gertel1, Yehuda Shoenfeld2 and Howard Amital3, 1Sheba Medical Center, Zabludowicz Center for Autoimmune Diseases, affiliated to Sackler Faculty of Medicine, Tel-Aviv University, Ramat Gan, Israel, 2Head Dept of Medicine B, Sheba Medical Center, Ramat-Gan, Israel, 3Sheba Medical Center, Tel-Hashomer, Israel

    Background/Purpose: Citrullinated peptides are major targets of disease-specific autoantibodies in rheumatoid arthritis (RA). We generated a multi-epitope citrullinated peptide (Cit-ME), derived from major prevalent citrullinated…
  • Abstract Number: 2821 • 2014 ACR/ARHP Annual Meeting

    Efficacy and Safety/Tolerability of Mavrilimumab, a Human GM-CSFRá Monoclonal Antibody in Patients with Rheumatoid Arthritis

    Gerd Burmester1, Iain B. McInnes2, Joel M. Kremer3, Pedro Miranda4, Mariusz Korkosz5, Jiri Vencovsky6, Andrea Rubbert-Roth7, Eduardo Mysler8, Sara Sandbach9, Matthew A. Sleeman10, Alex Godwood11, David Close12 and Michael Weinblatt13, 1Department of Rheumatology and Clinical Immunology, Charité - University Medicine Berlin, Berlin, Germany, 2University of Glasgow, Glasgow, United Kingdom, 3Medicine, Albany Medical College and the Center for Rheumatology, Albany, NY, 4Centro de Estudios Reumatologicos, Santiago, Chile, 5Inernal Medicine and Gerontology, Malopolskie Centrum Medyczne, Krakow, Poland, 6Rheumatology, Charles University Institute of Rheumatology, Praha, Czech Republic, 7Med Clinic I, University of Cologne, Koln, Germany, 8Rheumatology, OMI, Buenos Aires, Argentina, 9Clinical biologics, MedImmune Ltd, Cambridge, United Kingdom, 10Respiratory, Inflammation and Autoimmunity, MedImmune Ltd, Cambridge, United Kingdom, 11Clinical Biostatics and Data Management, MedImmune Ltd, Cambridge, United Kingdom, 12Clinical Development, MedImmune Ltd, Cambridge, United Kingdom, 13Rheumatology, Brigham & Women's Hospital, Harvard Medical School, Boston, MA

    Background/Purpose Granulocyte-macrophage colony-stimulating factor (GM-CSF) is implicated in RA pathogenesis via myeloid and granulocyte cell lineage activation. In a prior Phase 2a study (NCT01050998), mavrilimumab,…
  • Abstract Number: 2800 • 2014 ACR/ARHP Annual Meeting

    Tofacitinib Regulates Synovial Angiogenesis in Psoriatic Arthritis through Induction of Negative Feedback Inhibitors

    Wei Gao, Jennifer McCormick, Carl Orr, Mary Connolly, Ursula Fearon and Douglas J. Veale, Dublin Academic Medical Centre, Translational Rheumatology Research Group, Dublin, Ireland

    Background/Purpose: Psoriatic Arthritis (PsA) is a common, chronic immune-mediated inflammatory disease, characterised by synovitis, progressive destruction of articular cartilage/bone, and is associated with psoriasis. Janus…
  • Abstract Number: 1465 • 2014 ACR/ARHP Annual Meeting

    Follicular Helper T Cells Control Autoimmunity through IL-21/IL-21 Receptor Interaction in RA Patients

    Shikha Singla1, Minzi Chen2, Jerry Pounds Jr.2, Omar Khan2, Jerald M. Zakem2, Kismet Collins2, Tamika Webb-Detiege2, William E. Davis2, Robert Quinet2 and Xin Zhang3, 1Rheumatology, Ochner Medical Center, New Orleans, LA, 2Rheumatology, Ochsner Medical Center, New Orleans, LA, 3Institute of Translational Research, Ochsner Medical Center, New Orleans, LA

    Background/Purpose Rheumatoid Arthritis (RA) is an autoimmune disease characterized by chronic inflammation of the synovium, causing progressive joint destruction and reduction in quality of life…
  • Abstract Number: 366 • 2014 ACR/ARHP Annual Meeting

    Soluble 4-1BB Is a Marker of Joint Involvement and Disease Activity in Rheumatoid Arthritis

    Morten Aagaard Nielsen1, Thomas Andersen2, Kristian Stengaard-Pedersen3, Kim Hoerslev-Petersen4, Merete Lund Hetland5, Peter Junker6, Mikkel Ostergaard7, Malene Hvid1 and Bent Deleuran8, 1Department of Biomedicine, Aarhus University, Aarhus, Denmark, 2Dept. of Biomedicine, Aarhus University, Aarhus, Denmark, 3Rheumatology, Aarhus University Hospital, Aarhus, Denmark, 4Rheumatology, Research Unit at King Christian X Hospital for Rheumatic Diseases, Graasten, Denmark, 5DANBIO, Center for Rheumatology and Spine Diseases, Glostrup University Hospital, Glostrup, Denmark, Glostrup, Denmark, 6University of Southern Denmark, Odense, Denmark, 7Copenhagen University Hospital at Glostrup, Copenhagen, Denmark, 8Dept. of Rheumatology, Aarhus University Hospital, Aarhus, Denmark

    Background/Purpose 4-1BB is induced on T cells after antigen encounter and promotes clonal expansion and accumulation of high numbers of antigen-specific effector-type T cells primarily…
  • Abstract Number: 1727 • 2013 ACR/ARHP Annual Meeting

    Novel Selective Inhibitors Of Nuclear Export Attenuate Inflammation and Prevent Bone Mineral Density Loss In Multiple Preclinical Models Of Rheumatoid Arthritis

    Mwanasha Hamuza1, Yosef Landesman1, Boris Klebanov1, Michael Kauffman1, Sharon Shacham1, Judith Endres2, David A. Fox3 and Dilara McCauley1, 1Karyopharm Therapeutics Inc., Natick, MA, 2Rheumatology/Internal Medicine, University of Michigan Medical Center, Ann Arbor, MI, 3Rheumatology/Int Medicine, University of Michigan Medical Center, Ann Arbor, MI

    Background/Purpose: Exportin 1 (XPO1; also called chromosome region maintenance 1, CRM1) is a key protein that controls the export of ~220 cargo proteins and several…
  • Abstract Number: 1459 • 2013 ACR/ARHP Annual Meeting

    Multiple Cytokine Profiling Predicts The Effectiveness Of Switching Biologics In Rheumatoid Arthritis

    Kensuke Koyama1, Katsunori Ikari1, Atsuo Taniguchi2, Shigeki Momohara2 and Hisashi Yamanaka1, 1Institute of Rheumatology, Tokyo Women's Medical University, Tokyo, Japan, 2Institute of Rheumatology, Tokyo Women’s Medical University, Tokyo, Japan

    Background/Purpose: There is some rheumatoid arthritis (RA) patients with poor responses to certain biologics which requires switching to another biologics. However, there is no solid…
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Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. Academic institutions, private organizations and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part a scientific presentation or presentation of additional new information that will be available at the time of the meeting) is under embargo until Saturday, November 11, 2023.

Violation of this policy may result in the abstract being withdrawn from the meeting and other measures deemed appropriate. Authors are responsible for notifying financial and other sponsors about this policy. If you have questions about the abstract embargo policy, please contact the public relations department at [email protected].

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