ACR Meeting Abstracts

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Abstracts tagged "cytokines and rheumatoid arthritis (RA)"

  • Abstract Number: 880 • 2018 ACR/ARHP Annual Meeting

    Serum Cytokine and Chemokine Concentrations Predict Incident Cancer in US Veterans with Rheumatoid Arthritis

    Bryant R. England1, Harlan Sayles2, Punyasha Roul2, Apar Ganti3, Jeremy Sokolove4, William H. Robinson5, Grant W. Cannon6, Brian Sauer7, Joshua Baker8, Geoffrey M. Thiele2 and Ted R. Mikuls9, 1Rheumatology, VA Nebraska-Western Iowa Health Care System & University of Nebraska Medical Center, Omaha, NE, 2University of Nebraska Medical Center, Omaha, NE, 3VA Nebraska-Western IA Health Care System & University of Nebraska Medical Center, Omaha, NE, 4Division of Immunology and Rheumatology, Stanford University Medical Center, Mountain View, CA, 5Stanford University, Palo Alto, CA, 6Division of Rheumatology, Salt Lake City VA Medical Center and University of Utah, Salt Lake City, UT, 7Salt Lake City VA Medical Center and University of Utah, Salt Lake City, UT, 8Philadelphia VA Medical Center and University of Pennsylvania, Philadelphia, PA, 9VA Nebraska-Western Iowa Health Care System and University of Nebraska Medical Center, Omaha, NE

    Background/Purpose: The immune system plays a critical protective role in cancer (CA) development. Perturbations in immune signaling, including cytokine dysregulation, may disrupt this homeostatic balance.…
  • Abstract Number: 1017 • 2018 ACR/ARHP Annual Meeting

    Autoantigen Pentraxin-3 Is an Inflammatory Cytokine Storms Suppressor By Switching Monocytes Pyroptosis to Apoptosis in a Complement-Dependent Manner in Rheumatoid Arthritis

    Xuan Zhang1 and Xunyao Wu2, 1Rheumatology, Peking Union Medical College Hospital, Beijing, China, 2Peking Union Medical College Hospital, beijing, China

    Background/Purpose: A delayed diagnoses and therapy of ACPA (Anti cyclic citrullinated peptide antibody)-negative RA patients might be associated with effective serum biomarkers in clinic. Methods:…
  • Abstract Number: 1473 • 2018 ACR/ARHP Annual Meeting

    Performance of the Meso Scale Multiplex Platform in the Assessment of Serum Cytokines / Chemokines in Rheumatoid Arthritis

    Peter M. Maloley1, Bryant R. England2, Harlan Sayles1, Geoffrey M. Thiele1, Michael J. Duryee3, Jeffrey Payne4 and Ted R. Mikuls5, 1University of Nebraska Medical Center, Omaha, NE, 2Rheumatology, VA Nebraska-Western Iowa Health Care System & University of Nebraska Medical Center, Omaha, NE, 3Internal Medicine Division of Rheumatology, University of Nebraska Medical Center, Omaha, NE, 4College of Dentistry, University of Nebraska Medical Center, Lincoln, NE, 5Internal Medicine, Division of Rheumatology, VA Nebraska-Western Iowa Health Care System and University of Nebraska Medical Center, Omaha, NE

     Background/Purpose:  Cytokines and chemokines (CK) are central to RA pathogenesis, a fact underscored by the emergence of multiplex immunoassays for quantifying CK values in both…
  • Abstract Number: 2879 • 2018 ACR/ARHP Annual Meeting

    Plasma IL-23 and IL-25 Predict Response to Anti-TNF-α Therapy in Rheumatoid Arthritis

    Niamh Fanning1, Melanie J Millier2, John Highton2, Christopher Frampton3, Paul A Hessian2 and Lisa K. Stamp3, 1Medicine, University of Otago, Christchurch, Christchurch, New Zealand, 2Department of Medicine, University of Otago, Dunedin, New Zealand, 3University of Otago, Christchurch, New Zealand

    Background/Purpose: TNF-α inhibitors are among the most widely used biological-DMARDs in rheumatoid arthritis (RA). Means to predict response would allow for a more effective, targeted…
  • Abstract Number: 2425 • 2017 ACR/ARHP Annual Meeting

    Decline in CD8+IFNγ+ Subset but Rise in CD8+IL17+ on Methotrexate Treatment in Rheumatoid Arthritis

    Amit Sandhu1, Varun Dhir2, Shabeer Ahmad1, Prabhdeep Kaur1, Veena Dhawan3 and Archana Bhatnagar4, 1Internal Medicine, Postgraduate Institute of Medical Education and Research, Chandigarh, India, 2Internal Medicine (Rheumatology Unit), Postgraduate Institute of Medical Education and Research, Chandigarh, India, 3Experimental Medicine, Postgraduate Institute of Medical Education and Research, Chandigarh, India, 4Biochemistry, Panjab University, Chandigarh, India

    Background/Purpose: CD8 T cells comprise 40 % of all T cells in the synovial compartment and are detectable in he preclinical stages as well. They…
  • Abstract Number: 2701 • 2017 ACR/ARHP Annual Meeting

    TNFR2+ Regulatory T Cellssubpopulations ARE Highly Suppressive and Are Increased on Anti-TNF Treatment

    Francois Santinon1, Maxime Batignes2, Benoit Salomon3, Patrice Decker2, Marie-Christophe Boissier4, Luca Semerano5 and Natacha Bessis2, 1INSERM UMR 1125 University of Paris 13, Sorbonne Paris Cité, bobigny, France, 2INSERM UMR 1125 University of Paris 13, Sorbonne Paris Cité, Bobigny, France, 3Sorbonne Universités, UPMC Université Paris 06, INSERM, CNRS, Centre d'Immunologie et des Maladies Infectieuses (CIMI-Paris), Paris, France, 4Rheumatology Department, Assistance Publique – Hôpitaux de Paris (AP-HP), Avicenne Hospital, Bobigny, France, 5INSERM UMR 1125 University of Paris 13, Sorbonne Paris Cité and Assistance Publique – Hôpitaux de Paris (AP-HP), Avicenne Hospital, Rheumatology Department, France, Bobigny, France

    Background/Purpose: In rheumatoid arthritis (RA), regulatory T cells (Tregs) are defective in their suppressive capacities and fail to control chronic inflammation. TNF-α is involved in…
  • Abstract Number: 2870 • 2017 ACR/ARHP Annual Meeting

    Ex Vivo Comparison of Baricitinib, Upadacitinib, Filgotinib, and Tofacitinib for Cytokine Signaling in Human Leukocyte Subpopulations

    Iain B. McInnes1, Richard Higgs2, Jonathan Lee2, William L. Macias2, Songqing Na2, Robert A. Ortmann2, Guilherme Rocha2, Thomas Wehrman3, Xin Zhang2, Steven H. Zuckerman2 and Peter C. Taylor4, 1University of Glasgow, Glasgow, United Kingdom, 2Eli Lilly and Company, Indianapolis, IN, 3Primity Bio, Fremont, CA, 4NDORMS, University of Oxford, Oxford, United Kingdom

    Background/Purpose: Baricitinib (bari), an oral selective Janus kinase (JAK) 1/2 inhibitor, has been approved in the EU for the treatment of adults with moderately to…
  • Abstract Number: 22 • 2017 ACR/ARHP Annual Meeting

    Bone Regulatory Cytokine Production By B Cells in Rheumatoid Arthritis Is Dependent on NF-κb Activation and Autophagy Pathways

    Jason Glanzman1, Nida Meednu1, Victor Wang1, Wen Sun2, Lianping Xing3 and Jennifer H. Anolik1, 1Medicine- Allergy, Immunology and Rheumatology, University of Rochester Medical Center, Rochester, NY, 2Nanjing Medical University, Nanjing, China, 3Pathology & Lab Medicine, University of Rochester Medical Center, Rochester, NY

    Background/Purpose: Rheumatoid arthritis (RA) is a systemic autoimmune disease that often leads to joint damage, a process mediated by an imbalance between bone resorption and…
  • Abstract Number: 72 • 2017 ACR/ARHP Annual Meeting

    The Presence of IgM Rheumatoid Factor Impede Immunodetection of Tnfa on Circulating Extracellular Vesicles Obtained from Rheumatoid Arthritis Patients

    Onno J. Arntz1, Bartijn C.H. Pieters1, Rogier Thurlings2, Peter M. van der Kraan3, F van den Hoogen2 and Fons A.J. van de Loo3, 1Experimental Rheumatology, Radboudumc, Nijmegen, Netherlands, 2Rheumatology, Radboudumc, Nijmegen, Netherlands, 3Experimental Rheumatology, Radboud university medical center, Nijmegen, Netherlands

    Background/Purpose: Tumor-necrosis factor (TNF)-α plays a key role in the pathophysiology of rheumatoid arthritis (RA) and membrane bound TNFα is sufficient to induce arthritis in…
  • Abstract Number: 404 • 2017 ACR/ARHP Annual Meeting

    Gut Microbiota Modify Inflammatory Arthritis through Autoantibody Generation and Mucosal Cytokines Alteration

    Widian Jubair1, Sumitra Adhikari2, Nirmal Banda2 and Kristine Kuhn3, 1Rheumatology, University of Colorado, Aurora, CO, 2Division of Rheumatology, UC Denver School of Medicine, Denver, CO, 3Division of Rheumatology, University of Colorado School of Medicine, Aurora, CO

    Background/Purpose: The pathogenesis of rheumatoid arthritis (RA) is thought to be influenced by a combination of genetic and environmental factors. Observations of microbial dysbiosis in…
  • Abstract Number: 521 • 2017 ACR/ARHP Annual Meeting

    Update on the Clinical Phase 1 and Phase 2 Trials Investigating the Fully Human Immunocytokine Dekavil (F8IL10) in Patients with Rheumatoid Arthritis

    Mauro Galeazzi1, Gian Domenico Sebastiani2, Jürgen Wollenhaupt3, Jean Dudler4, Christof Specker5, Reinhard Voll6, Pascal Zufferey7, Piercarlo Sarzi Puttini8, Ombretta Viapiana9 and Franziska Bootz10, 1Rheumatology, University Hospital of Siena, Siena, Italy, 2Rheumatology, San Camillo Forlanini Hospital, Roma, Italy, 3Division of Reheumatology, Schoen-Klinik Hamburg-Eilbek Teaching Hospital of the University of Hamburg, Hamburg, Germany, 4Rheumatology, Cantonal Hospital Fribourg, Fribourg, Switzerland, 5Rheumatology, St. Josef Krankenhaus, Universitätsklinikum Essen, Esssen, Germany, 6Clinic for Rheumatology and Clinical Immunology, Medical Center University of Freiburg, Freiburg, Germany, 7Department of Rheumatology, University Hospital Lausanne, Lausanne, Switzerland, 8Rheumatology, Luigi Sacco Hospital, Milan, Italy, 9University Hospital Verona, Verona, Italy, 10Clinical Department, Philochem AG (Philogen Group), Otelfingen, Switzerland

    Background/Purpose: The antibody-based targeted pharmacodelivery of cytokines by means of immunocytokines has the potential to enhance therapeutic activity at the site of disease while sparing…
  • Abstract Number: 956 • 2017 ACR/ARHP Annual Meeting

    Inhibition of Fucosylation in Endothelial Cells Reduces Rheumatoid Arthritis Angiogenesis

    Takeo Isozaki, Airi Nishimi, Shinichiro Nishimi, Sho Ishii, Takahiro Tokunaga, Hidekazu Furuya, Kuninobu Wakabayashi and Tsuyoshi Kasama, Div of Rheumatology, Showa University School of Med, Shinagawa-ku Tokyo, Japan

    Background/Purpose: Glycosylation has been reported to associate with tumor invasion and metastasis. Fucosylation is involved the biological functions of adhesion molecules and growth factor receptors.…
  • Abstract Number: 957 • 2017 ACR/ARHP Annual Meeting

    A Disintegrin and Metalloprotease 15 Is Expressed on Rheumatoid Arthritis Synovial Tissue Endothelial Cells and Mediates Angiogenesis

    Shinichiro Nishimi, Takeo Isozaki, Airi Nishimi, Sho Ishii, Takahiro Tokunaga, Hidekazu Furuya, Kuninobu Wakabayashi and Tsuyoshi Kasama, Div of Rheumatology, Showa University School of Med, Shinagawa-ku Tokyo, Japan

    Background/Purpose: A disintegrin and metalloproteases (ADAMs) are reported that membrane-anchored glycoproteins composed of multiple distinct protein modules. ADAM-15 is one of them and is reported…
  • Abstract Number: 958 • 2017 ACR/ARHP Annual Meeting

    Tumor Necrosis Factor-α Induces Production of Eotaxin-1/CCL11 from Fibroblast-like Synoviocyte in Rheumatoid Arthritis

    Kuninobu Wakabayashi, Takeo Isozaki, Airi Nishimi, Shinichiro Nishimi, Sho Ishii, Takahiro Tokunaga, Hidekazu Furuya and Tsuyoshi Kasama, Div of Rheumatology, Showa University School of Med, Shinagawa-ku Tokyo, Japan

    Background/Purpose: Chemokine C-C motif ligand 11 (CCL11) also known as eotaxin-1 is a member of the CC chemokine family, which acts as a major chemoattractant…
  • Abstract Number: 1348 • 2017 ACR/ARHP Annual Meeting

    Swollen Joint Count, but Not Inflammatory Cytokines, Differs By Frequency of Fish Consumption in a Cross-Sectional Rheumatoid Arthritis Cohort

    Sara K. Tedeschi1, Joan Bathon2, Jon T. Giles3, Tzu-Chieh Lin4, Kazuki Yoshida5 and Daniel Solomon1, 1Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Boston, MA, 2Division of Rheumatology, Columbia University, College of Physicians & Surgeons, New York, NY, 3Division of Rheumatology, Columbia University College of Physicians & Surgeons, New York, NY, 4Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, 5Brigham and Women's Hospital, Boston, MA

    Background/Purpose: Omega-3 fatty acids downregulate pro-inflammatory cytokines, thus have been of interest as adjunctive rheumatoid arthritis (RA) therapy for decades. We previously reported an inverse…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM ET on November 14, 2024. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

Violation of this policy may result in the abstract being withdrawn from the meeting and other measures deemed appropriate. Authors are responsible for notifying colleagues, institutions, communications firms, and all other stakeholders related to the development or promotion of the abstract about this policy. If you have questions about the ACR abstract embargo policy, please contact ACR abstracts staff at [email protected].

ACR Abstract Embargo Policy

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. Academic institutions, private organizations and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part a scientific presentation or presentation of additional new information that will be available at the time of the meeting) is under embargo until Saturday, November 11, 2023.

Violation of this policy may result in the abstract being withdrawn from the meeting and other measures deemed appropriate. Authors are responsible for notifying financial and other sponsors about this policy. If you have questions about the abstract embargo policy, please contact the public relations department at [email protected].

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