Abstracts tagged "cytokines and proteinuria"

Abstract Number: 1940 • 2014 ACR/ARHP Annual Meeting
A Novel Murine Model of B Cell-Mediated Glomerular Injury Is Mediated By Cytokines
Alfred Kim¹, Shreeram Akilesh², Ania Koziell³, Sanjay Jain⁴, Jeffrey Hodgin⁵, Mark Miller⁶, Jeffrey Miner⁴ and Andrey Shaw⁷, ¹IM/Div of Rheumatology, Washington Univ School of Med, St. Louis, MO, ²Pathology & Immunolog, Washington University School of Medicine, Saint Louis, MO, ³Experimental Immunobiology, King's College, London, United Kingdom, ⁴Renal Division, Washington University School of Medicine, Saint Louis, MO, ⁵Nephrology, University of Michigan, Ann Arbor, MI, ⁶Infectious Diseases, Washington University School of Medicine, Saint Louis, MO, ⁷Pathology & Immunology/HHMI, Washington University School of Medicine, Saint Louis, MO
Background/Purpose Lupus nephritis (LN) remains the leading cause of mortality for SLE patients, and is associated with proteinuria and foot process effacement. Podocyte foot process effacement…
Abstract Number: 2795 • 2013 ACR/ARHP Annual Meeting
B Cell Derived Cytokines Induce Glomerular Injury in Mice
Alfred Kim¹, Shreeram Akilesh², Jeffrey Miner³ and Andrey Shaw⁴, ¹IM/Div of Rheumatology, Washington Univ School of Med, St. Louis, MO, ²Pathology, University of Washington, Seattle, WA, ³Renal Division, Washington University School of Medicine, Saint Louis, MO, ⁴Pathology & Immunology/HHMI, Washington University School of Medicine, Saint Louis, MO
Background/Purpose: Renal involvment remains the leading cause of mortality for SLE patients, and is associated with proteinuria and foot process effacement. In subsets of LN…
Abstract Number: 1742 • 2012 ACR/ARHP Annual Meeting
A Novel Murine Model of B Cell-Mediated Proteinuria Suggests Cytokines Mediate Podocyte Injury
Alfred Kim¹ and Andrey S. Shaw², ¹IM/Div of Rheumatology, Washington Univ School of Med, St. Louis, MO, ²Pathology & Immunology/HHMI, Washington University School of Medicine, Saint Louis, MO
Background/Purpose: B cell depletion therapies have been efficacious in several glomerulopathies. The contributions of B cells to proteinuria and foot process effacement remain unknown. The…

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