Abstracts tagged "cytokines and osteoarthritis"

Abstract Number: 1162 • 2015 ACR/ARHP Annual Meeting
IL37 Reduces Pro-Inflammatory Cytokine and Catabolic Enzyme Production in Human Chondrocytes: A Protective Role in Osteoarthritis?
Ellen van Geffen¹, Arjan van Caam², Elly Vitters², Henk van Beuningen², Esmeralda Blaney Davidson² and Peter M. van der Kraan², ¹Experimential Rheumatology, Radboud university medical center, Nijmegen, Netherlands, ²Experimental Rheumatology, Radboud university medical center, Nijmegen, Netherlands
Background/Purpose: Osteoarthritis (OA) is the most common joint disease, primarily characterized by progressive articular cartilage degradation. Cartilage destruction is assumed to be mediated by pro-inflammatory…
Abstract Number: 9 • 2012 ACR/ARHP Annual Meeting
Function of the Chondrocyte PI-3 Kinase Akt Signaling Pathway Is Stimulus Dependent
Richard F. Loeser and Meredith Greene, Section Of Molecular Medicine, Wake Forest School of Medicine, Winston-Salem, NC
Background/Purpose: Previous studies have shown that activation of the chondrocyte PI-3K-Akt signaling pathway by IGF-1 promotes chondrocyte survival and matrix synthesis. However, other studies have…

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