Abstracts tagged "cytokines and lupus nephritis"

Abstract Number: 562 • ACR/ARHP Annual Meeting 2013
The Knock-Out Of TWEAK Receptor/Fn14 Ameliorates Lupus Nephritis In MRL/Lpr Mice
Yumin Xia¹, Leal Herlitz², Simona Gindea¹, Jing Wen¹, Rahul Pawar¹, Alexander Misharin³, Harris R. Perlman⁴, Ping Wu⁵, Jennifer Michaelson⁵, Linda Burkly⁵ and Chaim Putterman⁶, ¹Albert Einstein College of Medicine, Bronx, NY, ²The Department of Pathology, Columbia University Medical Center, New York, NY, ³Medicine, Division of Rheumatology, Northwestern University, Chicago, IL, ⁴Northwestern University, Chicago, IL, ⁵Biogen Idec, Cambridge, MA, ⁶The Division of Rheumatology, Albert Einstein College of Medicine, Bronx, NY
Background/Purpose: Renal mesangial cells, podocytes, and tubular cells express Fn14, the sole confirmed receptor for the tumor necrosis factor (TNF)-family member cytokine TWEAK (TNF-like weak…