Abstract Number: 1029 • ACR/ARP Annual Meeting 2019
Epstein-Barr Virus Interleukin 10 in SLE Pathogenesis
Background/Purpose: Systemic Lupus Erythematosus (SLE) is a systemic autoimmune disease characterized by periods of elevated and suppressed disease activity. Epstein Barr Virus (EBV) has been…Abstract Number: 62 • ACR/ARHP Annual Meeting 2018
CCR6+CD4+ T Cells Drive IL-23R Signaling-Dependent Progression of Antigen-Induced Arthritis
Background/Purpose: The IL-23/IL-17A immune pathway is important for the progression of T cell-mediated arthritis. However, it is not known where IL-23R+ T cells locate during…Abstract Number: 904 • ACR/ARHP Annual Meeting 2015
Intracerebroventricular Tweak (TNF-like weak inducer of apoptosis) Induces Depressive-like Behavior and Cognitive Dysfunction in Non-Autoimmune Mice
Background/Purpose: Neuropsychiatric lupus (NPSLE) is a common disease manifestation in lupus patients; however, the underlying mechanisms are not fully understood. TWEAK is a cytokine member…Abstract Number: 1775 • ACR/ARHP Annual Meeting 2015
Fn14 Deficiency Protects Lupus-Prone Mice from Cutaneous Lesions Induced By Ultraviolet B (UVB) Irradiation
Background/Purpose: Sunlight, via ultraviolet B (UVB) irradiation, is a well-recognized trigger of cutaneous lupus erythematosus (CLE) skin lesions. TNF-like weak inducer of apoptosis (TWEAK), a…Abstract Number: 1856 • ACR/ARHP Annual Meeting 2015
Exosomes from Patients with Active Systemic Lupus Erythematosus Induce a Strong Inflammatory Response
Background/Purpose: Exosomes are 60–150 nm membrane vesicles that are secreted by various cells into surrounding body fluids including blood and urine. As vehicles for intercellular…Abstract Number: 2222 • ACR/ARHP Annual Meeting 2013
Positive Allosteric Modulation Of The Adenosine A2a Receptor Alters Inflammatory Cytokine Production and Alleviates Chronic Arthritis In Rats
Background/Purpose: Rheumatoid arthritis is a chronic systemic autoimmune disease characterized by inflammation and joint destruction; a consequence of which is the high local concentration of…Abstract Number: 1762 • ACR/ARHP Annual Meeting 2013
Endogenous IL-22 Regulates Th1 Responses and Plays a Pathogenic Role After the Onset of Arthritis
Background/Purpose: IL-22,belongs to the IL-10 family of cytokines and is primarily produced by CD4 T, NK and LTi cells. IL-22 plays a dual role depending…Abstract Number: 724 • ACR/ARHP Annual Meeting 2013
Dose-Dependent Suppression Of Cytokine Production From T Cells By a Novel Phosphoinositide 3-Kinase Delta Inhibitor
Background/Purpose: The use of specific cytokine inhibitors to treat inflammatory autoimmune conditions is common but typically utilizes monoclonal antibodies, fusion proteins, and other molecules whose…Abstract Number: 2201 • ACR/ARHP Annual Meeting 2012
Involvement of Interleukin-33 in the Pathogenesis of Sjögren’s Syndrome
Background/Purpose: To investigate the role of IL-33/ST2 in the pathophysiology of primary Sjögren’s syndrome (pSS) Methods: Serum levels of IL-33 and sST2 was determined by…Abstract Number: 530 • ACR/ARHP Annual Meeting 2012
S100A8/A9 Is Upregulated and Triggers the Secretion of Pro-Inflammatory Cytokines in Primary Sjögren’s Syndrome
Background/Purpose: To determine the involvement of S100A8/A9 in the pathogenesis of primary Sjögren’s syndrome (pSS) Methods: The serum levels of S100A8/A9, IL-17A and IL-17C were…
ACR Meeting Abstracts