ACR Meeting Abstracts

ACR Meeting Abstracts

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Abstracts tagged "cytokines and inflammation"

  • Abstract Number: 1029 • 2019 ACR/ARP Annual Meeting

    Epstein-Barr Virus Interleukin 10 in SLE Pathogenesis

    Neelakshi R. Jog1, Wade DeJager 1, Joel Guthridge 2 and Judith James 2, 1Oklahoma Medical Research Foundation, Oklahoma City, OK, 2Oklahoma Medical Research Foundation, University of Oklahoma Health Sciences Center, Oklahoma City, OK

    Background/Purpose: Systemic Lupus Erythematosus (SLE) is a systemic autoimmune disease characterized by periods of elevated and suppressed disease activity. Epstein Barr Virus (EBV) has been…
  • Abstract Number: 62 • 2018 ACR/ARHP Annual Meeting

    CCR6+CD4+ T Cells Drive IL-23R Signaling-Dependent Progression of Antigen-Induced Arthritis

    W Razawy1, N Salioska2, P Asmawidjaja3, A Otten-Mus4, N Kops5, M Oukka6, V Kuchroo7 and Erik Lubberts3, 1Rheumatology and Immunology, Erasmus MC, Rotterdam, Netherlands, 2Rheumatology, Erasmus MC, Rotterdam, Netherlands, 3Rheumatology and Immunology, Erasmus MC, University Medical Center, Rotterdam, Netherlands, 4Immunology, Erasmus MC, University Medical Center, Rotterdam, Netherlands, 5Orthopedics, Erasmus MC, Rotterdam, Netherlands, 6Pediatrics, Seattle Children's Research Institute, Seattle, WA, 7Center for Neurologic Diseases, Harvard Institute of Medicine, Boston, MA

    Background/Purpose: The IL-23/IL-17A immune pathway is important for the progression of T cell-mediated arthritis. However, it is not known where IL-23R+ T cells locate during…
  • Abstract Number: 1856 • 2015 ACR/ARHP Annual Meeting

    Exosomes from Patients with Active Systemic Lupus Erythematosus Induce a Strong Inflammatory Response

    Joo Youn Lee1, Jin Kyun Park1,2, Eun Young Lee3, Eun Bong Lee3 and Yeong Wook Song1,2, 1Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology and College of Medicine Seoul National University, Seoul, South Korea, 2Division of Rheumatology, Department of Internal Medicine, Seoul National University, Seoul, South Korea, 3Division of Rheumatology, Department of Internal Medicine, Seoul National University Hospital, Seoul, South Korea

    Background/Purpose: Exosomes are 60–150 nm membrane vesicles that are secreted by various cells into surrounding body fluids including blood and urine. As vehicles for intercellular…
  • Abstract Number: 1775 • 2015 ACR/ARHP Annual Meeting

    Fn14 Deficiency Protects Lupus-Prone Mice from Cutaneous Lesions Induced By Ultraviolet B (UVB) Irradiation

    Jessica Doerner1, Adam Friedman2, Linda Burkly3 and Chaim Putterman4, 1Albert Einstein College of Medicine, Bronx, NY, 2Department of Dermatology, George Washington School of Medicine and Health Sciences, Washington, DC, 3Biogen Idec, Cambridge, MA, 4The Division of Rheumatology, Albert Einstein College of Medicine, Bronx, NY

    Background/Purpose: Sunlight, via ultraviolet B (UVB) irradiation, is a well-recognized trigger of cutaneous lupus erythematosus (CLE) skin lesions. TNF-like weak inducer of apoptosis (TWEAK), a…
  • Abstract Number: 904 • 2015 ACR/ARHP Annual Meeting

    Intracerebroventricular Tweak (TNF-like weak inducer of apoptosis) Induces Depressive-like Behavior and Cognitive Dysfunction in Non-Autoimmune Mice

    Jing Wen1, Christopher Chen1, Ariel Stock1, Jessica Doerner1, Maria Gulinello1 and Chaim Putterman1,2, 1Albert Einstein College of Medicine, Bronx, NY, 2Division of Rheumatology, Albert Einstein College of Medicine, Bronx, NY

    Background/Purpose: Neuropsychiatric lupus (NPSLE) is a common disease manifestation in lupus patients; however, the underlying mechanisms are not fully understood. TWEAK is a cytokine member…
  • Abstract Number: 2222 • 2013 ACR/ARHP Annual Meeting

    Positive Allosteric Modulation Of The Adenosine A2a Receptor Alters Inflammatory Cytokine Production and Alleviates Chronic Arthritis In Rats

    Ajith A. Welihinda, Jordan A. Mechanic and Edward P. Amento, Molecular Medicine Research Institute, Sunnyvale, CA

    Background/Purpose: Rheumatoid arthritis is a chronic systemic autoimmune disease characterized by inflammation and joint destruction; a consequence of which is the high local concentration of…
  • Abstract Number: 1762 • 2013 ACR/ARHP Annual Meeting

    Endogenous IL-22 Regulates Th1 Responses and Plays a Pathogenic Role After the Onset of Arthritis

    Shivali Justa1, Xiaoqun Zhou2 and Sujata Sarkar3, 1Rheumatology & Arizona Arthritis Center, University of Arizona, Tucson, AZ, 2Rheumatology, University of Arizona, Tucson, AZ, 3Rheumatology and Arizona Arthritis Center, University of Arizona, Tucson, AZ

    Background/Purpose: IL-22,belongs to the IL-10 family of cytokines and is primarily produced by CD4 T, NK and LTi cells. IL-22 plays a dual role depending…
  • Abstract Number: 724 • 2013 ACR/ARHP Annual Meeting

    Dose-Dependent Suppression Of Cytokine Production From T Cells By a Novel Phosphoinositide 3-Kinase Delta Inhibitor

    Emily E. Way1, Kong Chen2, Kamal D. Puri3 and Jay K. Kolls2, 1Pediatric Rheumatology, Children's Hospital of Pittsburgh of UPMC, Pittsburgh, PA, 2Richard King Mellon Foundation Institute for Pediatric Research, Children's Hospital of Pittsburgh of UPMC, Pittsburgh, PA, 3Gilead Sciences, Inc., Seattle, WA

    Background/Purpose: The use of specific cytokine inhibitors to treat inflammatory autoimmune conditions is common but typically utilizes monoclonal antibodies, fusion proteins, and other molecules whose…
  • Abstract Number: 530 • 2012 ACR/ARHP Annual Meeting

    S100A8/A9 Is Upregulated and Triggers the Secretion of Pro-Inflammatory Cytokines in Primary Sjögren’s Syndrome

    Laura Weichselbaum1 and Muhammad S. Soyfoo2, 1Rheumatology, Department of rheumatology ,Hôpital Erasme, Brussels, Belgium, 2Rheumatology, Hôpital Erasme,Université Libre de Bruxelles, Brussels, Belgium

    Background/Purpose: To determine the involvement of S100A8/A9 in the pathogenesis of primary Sjögren’s syndrome (pSS) Methods: The serum levels of S100A8/A9, IL-17A and IL-17C were…
  • Abstract Number: 2201 • 2012 ACR/ARHP Annual Meeting

    Involvement of Interleukin-33 in the Pathogenesis of Sjögren’s Syndrome

    Ahmad Awada, Valérie Gangji and Muhammad S. Soyfoo, Rheumatology, Hôpital Erasme,Université Libre de Bruxelles, Brussels, Belgium

    Background/Purpose: To investigate the role of IL-33/ST2 in the pathophysiology of primary Sjögren’s syndrome (pSS) Methods: Serum levels of IL-33 and sST2 was determined by…
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ACR Pediatric Rheumatology Symposium 2020

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