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Abstracts tagged "CyTOF and monocytes"

  • Abstract Number: 35 • ACR/ARP Annual Meeting 2019

    Mass Cytometry Identifies Enhanced Histone H3 Citrullination and TNFα Production by CD14 Monocytes in Subjects At-Risk for Future Development of Rheumatoid Arthritis

    Yuko Okamoto1, Elena W.Y. Hsieh 2, Ronald P. Schuyler 3, Jennifer Seifert 4, Marie Feser 5, Jill Norris 6, M. Kristen Demoruelle 7, Kevin Deane 5 and V. Michael Holers 4, 1University of Colorado Denver, Division of Rheumatology, Aurora, CO, USA and Tokyo Women’s Medical University School of Medicine, Department of Rheumatology, Tokyo, Japan, Denver, 2University of Colorado School of Medicine, Department of Immunology and Microbiology, Aurora, CO, USA and University of Colorado School of Medicine, Children’s Hospital Colorado, Department of Pediatrics, Section of Allergy & Immunology, Aurora, CO, USA, Denver, 3University of Colorado School of Medicine, Department of Immunology and Microbiology Aurora, CO, USA, Denver, 4University of Colorado Denver, Division of Rheumatology, Aurora, CO, USA, Denver, 5University of Colorado Denver, Division of Rheumatology, Aurora, CO, USA, Aurora, CO, 6Colorado School of Public Health, Department of Epidemiology, Aurora, CO, USA, Denver, 7University of Colorado Denver, Division of Rheumatology, Aurora, CO, USA, Aurora

    Background/Purpose: Our group previously demonstrated that sputum neutrophils from subjects At-Risk for future rheumatoid arthritis (RA) spontaneously form neutrophil extracellular traps with elevated histone H3…

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