ACR Meeting Abstracts

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Abstracts tagged "cutaneous lupus erythematosus and interferons"

  • Abstract Number: 2933 • 2018 ACR/ARHP Annual Meeting

    Non-Invasive Tape Sampling Reveals RNA Gene Clusters in Cutaneous Lupus Erythematosus That Discriminate Affected from Unaffected and Healthy Volunteer Skin

    Joseph F. Merola1, Wenting Wang2, Carrie Wager3, Stefan Hamann2, Xueli Zhang3, Alice Thai2, Chris Roberts2, Christina Lam4, Cristina Musselli2, Galina Marsh2, Dania Rabah2, Catherine Barbey5, Nathalie Franchimont2 and Taylor L. Reynolds2, 1Clinical Unit for Research Innovation & Trials, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 2Biogen, Cambridge, MA, 3Formerly of Biogen, Cambridge, MA, 4Boston University Medical School, Boston, MA, 5Biogen, Zug, Switzerland

    Background/Purpose: Punch biopsy, the standard diagnostic and monitoring procedure for patients with cutaneous lupus erythematosus (CLE), impedes patient recruitment and follow up due to risk…
  • Abstract Number: 2857 • 2016 ACR/ARHP Annual Meeting

    Results from a Phase 0 Longitudinal Clinical Trial in Cutaneous Lupus Erythematosus: Analysis of the Type I IFN Signature in the Skin and Blood and Its Relationship with Disease Activity Scores and Autoantibody Profiles

    Jessica Schreiter1, Jarrat Jordan1, Matteo Cesaroni1, Marc Chevrier2, Alexa Piantone3, Ian Gourley3, Jacqueline Benson1 and Takahiro Sato1, 1Estrela Lupus Venture, Janssen Research and Development, LLC., Spring House, PA, 2Janssen Research and Development, LLC, Collegeville, PA, 3Immunology Translational Medicine, Janssen Pharmaceutical Research and Development, LLC, Spring House, PA

    Background/Purpose:  Type I IFN (IFN-I)-regulated gene expression is known to be elevated in blood and skin lesions of patients with two different forms of cutaneous…
  • Abstract Number: 3240 • 2016 ACR/ARHP Annual Meeting

    Interferon Kappa Is a Novel Type I IFN That Drives Cutaneous Inflammation in Systemic Lupus

    Jasmine Stannard1, Tamra J. Reed2, Emily Myers3, Lori Lowe4, Mrinal Sarkar4, Xianying Xing5, Celine C. Berthier6, Johann Gudjonsson4 and J. Michelle Kahlenberg7, 1Int. Medicine/Rheumatology, University of Michigan, Ann Arbor, MI, 2Internal Medicine, Rheumatology, University of Michigan, Ann Arbor, MI, 3Internal Medicine, Rheumatology, Georgetown University, Washington, DC, 4Dermatology, University of Michigan, Ann Arbor, MI, 5Dermatology, University of Michigan, University of Michigan, Ann Arbor, MI, 6Nephrology, Division of Nephrology, University of Michigan Medical Center, Ann Arbor, MI, 7Internal Medicine, Division of Rheumatology, Division of Rheumatology, University of Michigan Medical Center, Ann Arbor, MI

    Background/Purpose: Cutaneous lupus erythematosus (CLE) lesions are disfiguring, scarring, difficult to treat, and affect up to 70% of patients with systemic lupus erythematosus (SLE). Type…
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