Abstracts tagged "crystal-induced arthritis and inflammasome activation"

Abstract Number: 2083 • ACR/ARHP Annual Meeting 2017
The Inflammation Induced By Four Types of Calcium Pyrophosphate Crystals Depends on Their Capacity to Stimulate NF-κb and MAPK Pathways
Félix Renaudin¹, Laure Campillo-Gimenez², Pierre Gras³, Christèle Combes⁴, Martine Cohen-Solal¹, Frederic Liote⁵ and Hang-Korng Ea¹, ¹INSERM UMR1132, Paris Diderot University, Paris, France, ²Inserm UMR1132 Bioscar, Paris, France, ³CIRIMAT, INPT-UPS-CNRS, Toulouse, France, ⁴ENSIACET, CIRIMAT, INPT-UPS-CNRS, Toulouse, France, ⁵University Paris Diderot, Paris, France
Background/Purpose: Calcium pyrophosphate (CPP) crystal-induced inflammation is mainly driven by interleukin (IL)-1β. IL-1β production involves a two-step process including the formation of pro-IL-1β through NF-κB…