Abstracts tagged "Cryoglobulinemia"

Abstract Number: 1754 • 2013 ACR/ARHP Annual Meeting
Safety and Efficacy Of Peg-IFNa/Ribavirin/Protease Inhibitor Combination In 34 Patients With HCV-Mixed Cryoglobulinemia Vasculitis
David Saadoun¹, Stanislas Pol², Vincent Thibault³, Gilles Pialoux⁴, François Blanc⁵, Lucile Musset⁶, Alexandre Karras⁷, Olivier Decaux⁸, Jean-Marc Ziza⁹, Olivier Lambotte¹⁰ and Patrice Cacoub Sr.¹¹, ¹Groupe Hospitalier Pitié Salpétrière, Service de Médecine Interne, DHU i2B, Paris, France, ²Hepatology, Cochin Hospital, Paris, France, ³Virology, Pitié-Salpétrière, Paris, France, ⁴hôpital Tenon, Paris, France, ⁵hôpital Montpellier, Montpellier, France, ⁶Laboratoire d'immunochimie, Pitié- Salpêtrière, Paris, France, ⁷Nephrology, Hôpital Européen Georges Pompidou, APHP, Paris, France, ⁸Department of Internal Medicine, Rennes University Hospital, Rennes, France, ⁹Refferal center for bone and joint infections, Croix Saint Simon Hospital, Paris, France, ¹⁰Internal Medicine, Hopital Kremlin Bicêtre, Kremlin Bicêtre, France, ¹¹Department of Internal Medicine 2., CHU Pitié-Salpêtrière, Paris, France
Background/Purpose: The standard of care treatment of patients presenting a HCV-mixed cryoglobulinemia (MC) vasculitis includes Peg-IFNaplus Ribavirin, w/wo Rituximab. Thirty to 40% of patients are…
Abstract Number: 2639 • 2013 ACR/ARHP Annual Meeting
Long-Term Outcome of Monoclonal (type 1) Cryoglobulinemia
Antoine Néel¹, François Perrin¹, Olivier Decaux², Thomas Dejoie³, Maxime Halliez³, Béatrice Mahé⁴, Thierry Lamy⁵, Fadi Fakhouri⁶, Patrick Jego², Christian Agard¹, Cécile Vigneau⁷, Lucienne Guenet⁸, Bernard Grosbois⁹, Philippe Moreau⁴ and Mohamed Hamidou¹, ¹Internal Medicine Department, Nantes University Hospital, Nantes, France, ²Department of Internal Medicine, Rennes University Hospital, Rennes, France, ³Biochemistry Laboratory, Nantes University Hospital, Nantes, France, ⁴Hematology, Nantes University Hospital, Nantes, France, ⁵Hematology, Rennes University Hospital, Rennes, France, ⁶Nephrology, Nantes University Hospital, Nantes, France, ⁷Nephrology, Rennes University Hospital, Rennes, France, ⁸Biochemistry Laboratory, Rennes University Hospital, Rennes, France, ⁹Internal Medicine Department, Rennes University Hospital, Rennes, France
Background/Purpose: To investigate long-term outcome of symptomatic type 1 cryoglobulinemia and its determinants. Methods: Retrospective analysis of a prospective cohort from 2 French university hospitals.…
Abstract Number: 1657 • 2012 ACR/ARHP Annual Meeting
Peg-IFNa/Ribavirin/Protease Inhibitor Combination Is Highly Effective in HCV-Mixed Cryoglobulinemia Vasculitis
David Saadoun¹, Stanislas Pol², Pascal Lebray Sr.³, François Blanc⁴, Gilles Pialoux⁵, Alexandre Karras⁶, Dorothée Bazin⁷, Emmanuelle Plaisier⁸ and Patrice Cacoub Sr.⁹, ¹DHU 2iB Internal Medicine Referal Center for Autoimmune diseases Pitie Hospital, Paris, France, ²Hepatology, Cochin Hospital, Paris, France, ³Hepatology, Hôpital Pitié Salpétrière, Paris, France, ⁴hôpital Montpellier, Montpellier, France, ⁵hôpital Tenon, Paris, France, ⁶Nephrology, Hôpital Européen Georges Pompidou, APHP, Paris, France, ⁷Nouvel Hôpital Civil, Strasbourg, France, ⁸Nephrology, Tenon Hospital, Paris, France, ⁹Department of Internal Medicine 2., CHU Pitié-Salpêtrière, Paris, France
Background/Purpose: The standard of care treatment of patients presenting a HCV-mixed cryoglobulinemia (MC) vasculitis includes Peg-IFNa plus Ribavirin, w/wo Rituximab. Thirty to 40% of patients…
Abstract Number: 1623 • 2012 ACR/ARHP Annual Meeting
Serum Biomarkers Signature Identifies Patients with Overt B-Cell Non-Hodgkin Lymphoma Associated with Mixed Cryoglobulinemia in Chronic HCV Infection
Benjamin Terrier¹, Wahiba Chaara², Guillaume Geri³, David Saadoun⁴, Michelle Rosenzwajg Sr.⁵, Damien Sene Sr.⁶, Adrien Six², David Klatzmann Sr.⁵ and Patrice Cacoub Sr.⁷, ¹Internal Medicine, Cochin University Hospital, Paris, France, ²Laboratory I3 “Immunology, Immunopathology, Immunotherapy”, UMR CNRS 7211, INSERM U959, Groupe Hospitalier Pitié-Salpetrière, Paris, France, ³Intensive Care Unit, Cochin Hospital, Paris, France, ⁴Groupe Hospitalier Pitié Salpétrière, Service de Médecine Interne, DHU i2B, Paris, France, ⁵Laboratory I3 “Immunology, Immunopathology, Immunotherapy”, UMR CNRS 7211, INSERM U959, Paris, France, ⁶Department of Internal Medicine; 5 P3S post-genomic plateform, Groupe Hospitalier Pitié-Salpétrière, Université Pierre et Marie Curie, Paris, France, ⁷Department of Internal Medicine 2., CHU Pitié-Salpêtrière, Paris, France
Background/Purpose: Hepatitis C virus (HCV) is associated with B-cell disorders, including mixed cryoglobulinemia (MC) and B-cell non-Hodgkin lymphoma (B-NHL). Early diagnosis of B-NHL in HCV-infected…
Abstract Number: 1547 • 2012 ACR/ARHP Annual Meeting
A 4 Plus 2 Infusion Protocol of Rituximab Provides Long-Term Beneficial Effects in Patients with HCV-Associated Mixed Cryoglobulinemia with Membranoproliferative Nephritis and Severe Polyneuropathy
Dario Roccatello¹, Savino Sciascia², Simone Baldovino³ and Daniela Rossi¹, ¹Department of Rare, Immunologic, Hematologic and Immunohematologic Diseases, Centro di Immunopatologia e Documentazione su Malattie rare, Torino, Italy, ²Lupus Research Unit, The Rayne Institute, Kings College London School of Medicine, London, United Kingdom, ³Centro di Ricerche di Immunologia Clinica ed Immunopatologia e Documentazione su Malattie Rare (CMID), Università di Torino, Torino, Italy
Background/Purpose: Mixed cryoglobulinemia syndrome (MCs) is a systemic vasculitis characterized by multiple organ involvement due to the vascular deposition of immune-complexes, mainly the cryoglobulins. B…

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