Abstracts tagged "COVID-19"

Abstract Number: 0221 • ACR Convergence 2023
Post-COVID-19 Autoimmune Serologies and Immunophenotypes
Emily G. Oakes¹, Katherine Buhler², Ifeoluwakiisi Adejoorin¹, Kathryne Marks¹, Eilish Dillon¹, Jack Ellrodt¹, Jeong Yee¹, Deepak Rao¹, May Choi³ and Karen Costenbader⁴, ¹Brigham and Women's Hospital, Boston, MA, ²University of Calgary; Cumming School of Medicine, Calgary, AB, Canada, ³University of Calgary, Calgary, AB, Canada, ⁴Brigham and Women's Hospital and Harvard Medical School, Boston, MA
Background/Purpose: Autoimmunity after COVID-19 infection has been reported. We examined connective tissue disease (CTD) symptoms and autoantibodies, SARS-CoV-2 serologies, and T and B cell immunophenotypes…
Abstract Number: 1064 • ACR Convergence 2023
Seroconversion Rates in Rituximab-Treated Rheumatic Patients Receiving COVID-19 Vaccination
Ryan Wilson¹, Junaid Awan², Mary Brady², Ciara Hunt², Fahd Adeeb³ and alexander fraser⁴, ¹University of Limerick, Buncrana, Ireland, ²University of Limerick, Limerick, Ireland, ³RCSI & UCD (Ireland) Malaysia Campus (RUMC), Malaysia, Malaysia, ⁴HSE, Limerick, Ireland
Background/Purpose: COVID-19 has increased the mortality rates among rheumatic patients, mainly those immunocompromised or with underlying comorbidities. During the COVID-19 vaccine development, patients on immunomodulatory…
Abstract Number: 1672 • ACR Convergence 2023
Association of COVID-19 Vaccinations with Flares of Systemic Rheumatic Disease: A Case-Crossover Study
Genna Braverman¹, Medha Barbhaiya², Minerva Nong¹, Vivian Bykerk³, Nathaniel Hupert⁴, Colby Lewis V⁴ and Lisa Mandl², ¹Hospital for Special Surgery, New York, NY, ²Hospital for Special Surgery, Weill Cornell Medicine, New York, NY, ³Department of Rheumatology, Hospital for Special Surgery, New York, NY, ⁴Weill Cornell Medicine, New York, NY
Background/Purpose: Fear of flare contributes to COVID-19 vaccine hesitancy in patients with systemic rheumatic diseases (SRD). Accurately ascertaining post-vaccine SRD flares and differentiating them from…
Abstract Number: 1849 • ACR Convergence 2023
Impact of the First Three Waves of the Covid-19 Pandemic on Everyday Restrictions and Clinical Care of Patients with Spondyloarthritis Across Europe – Results from the EuroSpA Collaboration
Brigitte Michelsen¹, Bente Glintborg², Kim Lauper³, Bjorn Gudbjornsson⁴, Lykke Ørnbjerg⁵, Gerdur Maria Gröndal⁶, Karin Laas⁷, Sigrid Vorobjov⁸, Dan Nordstrom⁹, Heikki Relas⁹, Adrian Ciurea¹⁰, Burkhard Moeller¹¹, Isabel Castrejon¹², Lucia Otero-Valera¹³, Ziga Rotar¹⁴, Katja Perdan Pirkmajer¹⁵, Anne Gitte Loft¹⁶, Jakub Zavada¹⁷, Karel Pavelka¹⁸, Eirik Kristianslund¹⁹, Tore Kvien²⁰, Marleen van de Sande²¹, Pasoon Hellamand²², Florenzo Iannone²³, Roberto F. Caporali²⁴, Ana Maria Rodrigues²⁵, Maria Jose Santos²⁶, Catalin Codreanu²⁷, Corina Mogosan²⁸, Merete Hetland⁵ and Mikkel Østergaard²⁹, ¹Rigshospitalet Glostrup; Diakonhjemmet Hospital; Sørlandet Hospital, Copenhagen, Denmark, ²Rigshospitalet Glostrup, University of Copenhagen, Virum, Denmark, ³Geneva University Hospitals, Genève, Switzerland, ⁴Centre for Rheumatology Research, University Hospital, Reykjavik, Iceland, ⁵Copenhagen Center for Arthritis Research, Rigshospitalet, Copenhagen, Denmark, ⁶Landspitali University Hospital; University of Iceland, Reykjavik, Iceland, ⁷Department of Rheumatology, East-Tallinn Central Hospital, Tallinn, Estonia, ⁸National Institute for Health Development, Tallinn, Estonia, ⁹Helsinki University Hospital, Helsinki, Finland, ¹⁰University Hospital Zurich, Zürich, Switzerland, ¹¹Inselspital - University Hospital Bern, Bern, Switzerland, ¹²Hospital Universitario Gregorio Marañón, Madrid, Spain, ¹³Spanish Society of Rheumatology, Madrid, Spain, ¹⁴University Medical Centre Ljubljana, Ljubljana, Slovenia, ¹⁵University Medical Centre Ljubljana; University of Ljubljana, Ljubljana, Slovenia, ¹⁶Aarhus University, Horsens, Denmark, ¹⁷Institute of Rheumatology; Charles University, Prague, Czech Republic, ¹⁸Institut of Rheumatology and Department of Rheumatology, First Faculty of Medicine, Charles University, Praha, Czech Republic, ¹⁹Diakonhjemmet Hospital, Oslo, Norway, ²⁰Center for Treatment of Rheumatic and Musculoskeletal Diseases (REMEDY), Diakonhjemmet Hospital, Oslo, Norway, ²¹Amsterdam UMC, University of Amsterdam, Department of Rheumatology & Clinical Immunology and Department of Experimental Immunology, Amsterdam Infection & Immunity Institute; Amsterdam Rheumatology & Immunology Center (ARC), Academic Medical Center, Amsterdam, Netherlands, ²²Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, Netherlands, ²³Rheumatology Unit, Department of Precision and Regenerative Medicine and Ionian Area, University of Bari "Aldo Moro", Bari, Italy, ²⁴Department of Clinical Sciences and Community Health, University of Milan, and Department of Rheumatology and Medical Sciences, ASST Gaetano Pini-CTO, Milano, Italy, ²⁵Sociedade Portuguesa de Reumatologia; Nova Medical School; Hospital dos Lusíadas, Lisbon, Portugal, ²⁶Hospital Garcia de Orta, Almada, Lisboa, Portugal, ²⁷Center for Rheumatic Diseases, Bucharest, Romania, ²⁸University of Medicine and Pharmacy, Bucharest, Romania, ²⁹Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Centre for Head and Orthopaedics, Rigshospitalet; University of Copenhagen, Copenhagen, Denmark
Background/Purpose: The Covid-19 pandemic constituted major challenges for health-care services worldwide. We aimed to compare Covid-19 restrictions across Europe during the first three waves of…
Abstract Number: 2478 • ACR Convergence 2023
Effect of Conventional and Biologic Disease-Modifying Anti-Rheumatic Drugs on the Antibody Response to Four Doses of COVID-19 mRNA Vaccines in Children with Autoimmune and Rheumatic Diseases
Janna Shapiro¹, Florence Choi², Amy Xu³, Trang Duong⁴, Anne-Claude Gingras⁵, Sasha Bernatsky⁶, Susanne (Susa) Benseler⁷ and Rae Yeung⁸, ¹University of Toronto, Toronto, ON, Canada, ²Hong Kong Hospital Authority, Hong Kong, Hong Kong, ³Division of Rheumatology, Department of Paediatrics, The Hospital for Sick Children, University of Toronto, Toronto, ON, Canada, ⁴The Hospital for Sick Children, Toronto, ON, Canada, ⁵Lunenfeld-Tanenbaum Research Institute at Mount Sinai Hospital Sinai Health, Toronto, ON, Canada, ⁶Research Institute of the McGill University Health Centre, Montreal, QC, Canada, ⁷University of Calgary, Calgary, AB, Canada, ⁸The Hospital for Sick Children, University of Toronto, Toronto, ON, Canada
Background/Purpose: Children with rheumatic and autoimmune diseases are often treated with conventional or biologic disease-modifying antirheumatic drugs (cDMARDs and bDMARDs) to control disease. While effective,…
Abstract Number: 0144 • ACR Convergence 2023
COVID-19 Infection in People with Immune Mediated Inflammatory Diseases Who Received SARSCo-V2 Vaccines
Tetiana Shcholok¹, Charles N Bernstein¹, Catherine Card², RuthAnn Marrie¹, Christine Mesa², John Kim² and Carol Hitchon¹, ¹University of Manitoba, Winnipeg, MB, Canada, ²Public Health Agency of Canada, Winnipeg, MB, Canada
Background/Purpose: Vaccines targeting the SARSCo-V2 virus protect against severe COVID-19 infection. Some immunosuppressive therapies impair SARSCo-V2 vaccine mediated immunogenicity and may increase the risk of…
Abstract Number: 0222 • ACR Convergence 2023
Predictors of Adverse Prognosis Following Hospitalization for COVID-19 Infection in Patients with Immune Mediated Inflammatory Diseases Treated with Rituximab
Pei-hsinq Lai¹, Ting-wei Chang², Shih-hsun Lan², Chiao-Feng Cheng², Cheng-Hsun Lu² and Song-Chou Hsieh², ¹Taipei City Hospital, Zhongxiao Branch, Taipei, Taiwan, ²National Taiwan University Hospital, Taipei, Taiwan
Background/Purpose: Rituximab (RTX) is widely used in immune mediated inflammatory disease (IMID) patients refractory to conventional treatment. Previous studies have indicated that RTX in IMID…
Abstract Number: 1065 • ACR Convergence 2023
Association Between COVID-19 and Disease-Modifying Antirheumatic Drugs
Ogheneyoma Akpoviroro¹, Nathan Sausers², Oghenetejiro Akpoviroro³, Queeneth Uwandu¹, Myriam Castagne⁴, Elga Rodrigues⁴, Lefulesele Khoalone¹, sara Humayun¹ and Jameson Woodard¹, ¹Geisinger Wyoming Valley Medical Center, Wilkes-Barre, PA, ²Pennsylvania State University, State College, PA, ³Mater Dei Hospital, Msida, Malta, ⁴Boston University, Boston, MA
Background/Purpose: Describe patients(pts) hospitalized with COVID-19C(C19) who were on disease modifying antirheumatic drugs (DMARDs) before admission(BA); assess if clinical outcomes differed from pts without BA…
Abstract Number: 1673 • ACR Convergence 2023
Immunomodulatory Treatment and Autoimmune Patient Responses to COVID-19 Booster Shots: Results from the Covid-19 VaccinE Response in Rheumatology Patients (COVER) Study
Amy S. Mudano¹, Gary Cutter², Ted R Mikuls³, Geoffrey Thiele⁴, Emily Holladay², Kevin Withrop⁵, Mark Law⁴, Bart Hamilton⁴, Monique Bastidas⁶, Michael Zikry⁶, Kelly Chun⁶, Michael George⁷ and Jeffrey Curtis², ¹Illumination Health, Hoover, AL, ²University of Alabama at Birmingham, Birmingham, AL, ³Division of Rheumatology and Immunology, University of Nebraska Medical Center, Omaha, NE, ⁴University of Nebraska Medical Center, Omaha, NE, ⁵Oregon Health & Science University, Schools of Medicine and Public Health,, Portland, OR, ⁶Labcorp, Calabasas, CA, ⁷University of Pennsylvania, Philadelphia, PA
Background/Purpose: Given an increased risk of COVID-19 in patients with autoimmune conditions, we must better understand the immunogenicity and safety of SARS-CoV-2 vaccines in people…
Abstract Number: 1928 • ACR Convergence 2023
Response to Sars-Cov2 Vaccination in Rheumatic and Neurological Patients Treated with Different Immunosuppressive Therapies
Cristina Calomarde Gomez¹, Raquel Ugena García¹, Julia Valera², Melisa Mena², Maria Esteve², Irma Casas², jose Antonio Dominguez-Benitez², lidia Carabias-Ane², isaac Nuño-Ruiz², Cristina ramo-Tello², Javier Santesmases², Lourdes Mateo Soria³ and Melania Martinez Morillo¹, ¹Rheumatology department. Hospital Universitari Germans Trias i Pujol, Badalona, Spain, ²Hospital Universitari Germans Trias i Pujol, Badalona, Spain, ³HOSPITAL GERMANS TRIAS I PUJOL, Badalona, Spain
Background/Purpose: Vaccination against SARS-CoV2 has been the primary global strategy to prevent severe forms of this respiratory infection. However, multiple studies have shown that patients…
Abstract Number: 2511 • ACR Convergence 2023
Superior SARS-CoV-2 Antibody Response Achieved in Rituximab-treated Patients When Vaccinated Against COVID-19 Before Compared to After Rituximab Initiation – Guidance for Future Vaccination Strategies
Christian Ammitzbøll¹, Marianne Kragh Thomsen², Lars Erik Bartels¹, Marie-Louise From Hermansen¹, Mathias Hänel³, Rasmus Klose-Jensen¹, Mads Christian Lamm Larsen¹, Cecile Bo Hansen⁴, Morgan Oliver Lauritsen¹, Susan Mikkelsen⁵, Clara Mistegaard¹, Morten Aagaard Nielsen¹, Esben Naeser¹, Janne Bille Mønster Olesen⁵, Peter Garred⁴, Christian Erikstrup⁵, Ellen-Margrethe Hauge⁶ and Anne Troldborg⁶, ¹Rheumatology, Aarhus University Hospital, Aarhus, Denmark, ²Clinical Microbiology, Aarhus University Hospital, Aarhus, Denmark, ³Rheumatollogy, Aarhus University Hospital, Aarhus, Denmark, ⁴Clinical Immunology, sect. 7631, Rigshospitalet, Copenhagen, Denmark, ⁵Clinical Immunology, Aarhus University Hospital, Aarhus, Denmark, ⁶Aarhus University Hospital, Aarhus, Denmark
Background/Purpose: Rituximab (RTX) treatment significantly decreases the antibody response to COVID-19 vaccines, raising concerns about its use. However, unlike during the pandemic, most patients initiating…
Abstract Number: 0152 • ACR Convergence 2023
Long Covid in Persons with Self-Reported Arthritis – Symptoms, Associated Factors and Functional Limitations
Debbie Ehrmann Feldman¹ and Barbara Mazer², ¹Université de Montréal, Montreal, QC, Canada, ²McGill University, Montreal, QC, Canada
Background/Purpose: Long covid, a condition whereby signs and symptoms post covid-19 infection continue for more than 12 weeks and are not explained by an alternative…
Abstract Number: 0223 • ACR Convergence 2023
Severity and Risk Factors of Hospitalization of Omicron in Patients with Rheumatoid Arthritis
Yan Wang¹, mengyao zhang², Sitian Zang¹, liang luo³, Chun Li¹, Jing He¹ and zhanguo li², ¹Peking University People’s Hospital, Beijing, China, ²Peking University People's Hospital, Beijing, China, ³Department of Chinese Medicine, the People's Hospital of Yubei District of Chongqing City, Chongqing, China; Department of Rheumatology and Immunology, Peking University People's Hospital, Beijing, China
Background/Purpose: There is still lack of data on the prognosis of patients with RA who have been infected with SARS-Cov-2 Omicron variant, a new strain…
Abstract Number: 1093 • ACR Convergence 2023
Development of Adaptive Immunity Against Different SARS-CoV-2 Variants over the Course of Three COVID-19 Vaccinations in Patients with Inflammatory Rheumatic Diseases
Liam Huppke¹, Paul Wratil², Marie Bischof², Stefan Wolfrum¹, Fabian Ullrich¹, Delila Singh¹, Julia Lichtnekert¹, Lea Grümme¹, Christina Gebhardt¹, Klaus Krüger³, Franziska Wiesent⁴, Alla Skapenko¹, Oliver Keppler⁵ and Hendrik Schulze-Koops⁶, ¹Division of Rheumatology and Clinical Immunology, Department of Internal Medicine IV, University of Munich, Munich, Germany, ²Max von Pettenkofer Institute & Gene Centre, Virology, National Reference Centre for Retroviruses, LMU Munich, Munich, Germany, ³Praxiszentrum St. Bonifatius, Munich, Germany, ⁴Endokrinologikum München, Munich, Germany, ⁵Max von Pettenkofer Institute & Gene Centre, Virology, National Reference Centre for Retroviruses, LMU München, Munich, Germany, ⁶Division of Rheumatology and Clinical Immunology, Department of Internal Medicine IV, Ludwig-Maximilians–University Munich, Munich, Germany
Background/Purpose: Even though individuals with inflammatory rheumatic diseases (IRDs) were excluded from the SARS-CoV-2 vaccine trails, studies have shown that these individuals at risk of…
Abstract Number: 1677 • ACR Convergence 2023
Two-week Break in Methotrexate Treatment and COVID-19 Vaccine Response. Results of the Vaccine Response on off Methotrexate (VROOM) Study, an Open Label, Prospective, Two-arm Parallel-group, Multi-center, Superiority, Randomized Controlled Trial
Abhishek Abhishek¹, Nicholas Peckham², Corinna Pade³, Joseph Gibbons³, Lucy Cureton², Anne Francis², Vicki Barber², Jennifer Williams², duncan Appelbe², lucy Eldridge², patrick Julier², daniel Altmann⁴, James Bluett⁵, Tim Brooks⁶, Laura Coates², ines Rombach⁷, Amanda Semper⁶, Ashley Otter⁶, Ana Valdes¹, Jonathan Nguyen-Van-Tam¹, Hywel Williams¹, Aine McKnight³, Rosemary Boyton⁴ and jonathan Cook², ¹University of Nottingham, Nottingham, United Kingdom, ²University of Oxford, Oxford, United Kingdom, ³Queen Mary University of London, London, United Kingdom, ⁴Imperial College London, London, United Kingdom, ⁵University of Manchester, Manchester, United Kingdom, ⁶UK Health Security Agency, Porton Down, United Kingdom, ⁷University of Sheffield, Sheffield, United Kingdom
Background/Purpose: Immunosuppressive treatments inhibit vaccine-induced immunity. We evaluated if a two-week interruption of methotrexate treatment immediately after COVID-19 booster improved antibody response against spike protein…

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