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Abstracts tagged "complement inhibitors and safety"

  • Abstract Number: 978 • ACR/ARHP Annual Meeting 2016

    A Randomized Clinical Trial of CCX168, an Orally Administered C5aR Inhibitor for Treatment of Patients with ANCA-Associated Vasculitis

    Peter A. Merkel1, John Niles2, Richard Jimenez3, Robert F. Spiera4, Brad H. Rovin5, Andrew Bomback6, Christian Pagnoux7, Antonia Potarca8, Thomas J. Schall9 and Pirow Bekker9, 1Division of Rheumatology, Univ of Pennsylvania; Perelman School of Med, Philadelphia, PA, 2Massachusetts General Hospital, Boston, MA, 3Rheumatology, The Seattle Arthritis Clinic, University of Washington Medicine, Northwest Hospital and Medical Center, Seattle, WA, 4Hospital for Special Surgery, Cornell, New York, NY, 5Ohio State University Medical Center, Columbus, OH, 6Columbia University Medical Center, New York, NY, 7Division of Rheumatology, Mount Sinai Hospital, University Health Network, University of Toronto, Toronto, Canada, Toronto, ON, Canada, 8ChemoCentryx, Inc., Mountain View, CA, 9ChemoCentryx, Mountain View, CA

    Background/Purpose:  Complement 5a (C5a) is involved in the pathogenesis of anti-neutrophil cytoplasm antibody (ANCA)-associated vasculitis (AAV). CCX168 is an orally administered, small molecule selective inhibitor of…

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