Abstracts tagged "complement deficiency and systemic sclerosis"

Abstract Number: 1705 • 2014 ACR/ARHP Annual Meeting
The Lectin Pathway of Complement – a Potential Role in the Pathogenesis and Disease Manifestations of Systemic Sclerosis
Michael Osthoff^1,2, Gene-Siew Ngian^2,3,4, Melinda Dean⁵, Mandana Nikpour⁶, Wendy Stevens⁷, Susanna Proudman⁸, Damon Eisen¹ and Joanne Sahhar^3,9, ¹Victorian Infectious Diseases Service, Royal Melbourne Hospital, Parkville, Australia, ²Department of Medicine, The University of Melbourne, Melbourne, Australia, ³Department of Rheumatology, Monash Medical Centre, Clayton, Australia, ⁴Department of Rheumatology, Royal Melbourne Hospital, Parkville, Australia, ⁵Research and Development, Australian Red Cross Blood Service, Brisbane, Australia, ⁶Department of Medicine (St Vincent's Hospital), University of Melbourne, Fitzroy, Australia, ⁷Department of Rheumatology, St. Vincent’s Hospital, Fitzroy, Australia, ⁸Rheumatology Unit, Royal Adelaide Hospital, Adelaide, Australia, ⁹Monash Health, Melbourne, Australia
Background/Purpose: Repetitive episodes of ischemia and reperfusion (I/R) are a cardinal feature of the pathogenesis of systemic sclerosis (SSc), which precedes tissue fibrosis. The complement…

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