Abstracts tagged "Complement deficiency and juvenile dermatomyositis"

Abstract Number: 2863 • 2013 ACR/ARHP Annual Meeting
Copy Number Variations Of Complement C4A and C4B Genes Are Genetic Risk Factor and Disease Modification Factor, Respectively, For Juvenile Dermatomyositis
Anjali Patwardhan¹, Katherine Lintner², Lisa G. Rider³, Frederick W. Miller³, Terrance O'Hanlon³, Yee Ling Wu⁴, Bi Zhou², Huanyu Wang⁴, David Newsom⁵, Peter White⁵, Charles H. Spencer⁶ and C. Yung Yu², ¹Pediatric Rheumatology, University of Missouri Women's and Children's Hospital, Columbia, MO, ²Center for Molecular and Human Genetics, The Research Institute at Nationwide Children's Hospital and The Ohio State University, Columbus, OH, ³Environmental Autoimmunity Group, NIEHS, NIH, Bethesda, MD, ⁴The Research Institute at Nationwide Children's Hospital and The Ohio State University, Columbus, OH, ⁵Biomedical Genomics Core, The Research Institute at Nationwide Children's Hospital and The Ohio State University, Columbus, OH, ⁶Rheumatology, Nationwide Childrens Hospital, Columbus, OH
Background/Purpose: Juvenile Dermatomyositis (JDM) is a systemic and inflammatory vasculopathy that affects mainly proximal muscles and skin in children. It is a rare but severe…

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