Abstracts tagged "collagen and human leukocyte antigens (HLA)"

Abstract Number: 1946 • 2015 ACR/ARHP Annual Meeting
A Novel HLA-DRB1*10:01 Restricted T Cell Epitope from Citrullinated Type II Collagen Relevant for Rheumatoid Arthritis
Karine Chemin¹, Sabrina Pollastro², Eddie James³, Changrong Ge⁴, Inka Albrecht⁵, Jessica Herrath⁶, Christina Gerstner⁷, Thais Rizzi², Karolina Tandre⁸, Lars Rönnblom⁸, Anca I Catrina⁹, Rikard Holmdahl¹⁰, L. Klareskog¹¹, Niek De Vries¹² and Vivianne Malmström¹¹, ¹Medicine, Rheumatology Unit, Department of Medicine, Solna, Karolinska Institutet, Stockholm, Sweden, ²Department of Clinical Immunology and Rheumatology, Amsterdam, Netherlands, ³Benaroya Research Institute at Virginia Mason, Seattle, WA, ⁴Department of Medical Biochemistry and Biophysics, Medical Inflammation Research, Karolinska Institute, Stockholm, Sweden, ⁵Rheumatology Unit, Department of Medicine, Solna, Karolinska Institutet, Stockholm, Sweden, ⁶Department of Medicine,, Rheumatology Unit, Department of Medicine, Solna, Karolinska Institutet, Stockholm, Sweden, ⁷Department of Medicine, Rheumatology Unit, Karolinska University Hospital, Solna, Stockholm, Sweden, ⁸Section of Rheumatology, Department of Medical Sciences, Uppsala University, Uppsala, Sweden, ⁹Unit of Rheumatology, Department of Medicine Solna, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden, ¹⁰Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden, ¹¹Rheumatology Unit, Department of Medicine, Karolinska Institutet, Stockholm, Sweden, ¹²Dept. of Clinical Immunology & Rheumatology, Amsterdam Rheumatology and immunology Center, Academic Medical Center/University of Amsterdam, Amsterdam, Netherlands
Background/Purpose: Antibodies against citrullinated collagen type II (Cit-CII) are common in sera and synovial fluids of Rheumatoid Arthritis (RA) patients, whereas the known CII T-cell…

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