Abstracts tagged "collagen and histone acetylation"

Abstract Number: 2709 • 2017 ACR/ARHP Annual Meeting
Histone Deacetylase 1 (HDAC1): A Novel Therapeutic Target for Patients with Rheumatoid Arthritis
Lisa Goschl^1,2, Michael Bonelli³, Victoria Saferding⁴, Teresa Peglej², Sylvia Knapp⁵, Johan Bäcklund⁶, Christoph Bock⁵, Patrick Matthias⁷, Kiyoshi Hirahara⁸, Clemens Scheinecker¹, Günter Steiner⁹, Josef S. Smolen¹ and Wilfried Ellmeier², ¹Medical University of Vienna, Devision of Rheumatology, Vienna, Austria, ²Medical University of Vienna,Institute of Immunology, Center for Pathophysiology, Infectiology and Immunology, Vienna, Austria, ³Rheumatology, Medical University of Vienna, Vienna, Austria, ⁴Medical University of Vienna, Austria, Vienna, Austria, ⁵CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria, ⁶Karolinska Institute,Department of Medical Biochemistry and Biophysics, Stockholm, Sweden, ⁷Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland, ⁸Department of Immunology, Graduate School of Medicine, Chiba University, Chiba, Japan, ⁹Medical University of Vienna, Dvision of Rheumatology, Vienna, Austria
Background/Purpose: Autoreactive T cells drive the inflammatory process, which leads to an irreversible destruction of the joints. Gene transcription and regulation of proinflammatory cytokine production…

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