Abstracts tagged "collagen and fibrosis"

Abstract Number: 1054 • ACR/ARP Annual Meeting 2019
Analysis of Serum Markers Across the Scleroderma Spectrum Shows Subset and Stage Specific Profiles of Fibrogenesis
Kristina Clark¹, Corrado Campochiaro ¹, Katherine Nevin ², Eszter Csomor ², Nicholas Galwey ², Mary Morse ², Nicolas Wisniacki ², Shaun Flint ², Voon Ong ³, Emma Derrett-Smith ¹ and Christopher Denton ⁴, ¹University College London, London, United Kingdom, ²GlaxoSmithKline, Stevenage, United Kingdom, ³UCL Medical School, Royal Free Campus, London, ⁴University College London Division of Medicine, Centre for Rheumatology and Connective Tissue Diseases, London, UK, London, United Kingdom
Background/Purpose: Systemic sclerosis (SSc) is characterised by autoimmunity, fibrosis and vasculopathy. There is striking heterogeneity in skin fibrosis that is likely to reflect the balance…
Abstract Number: 1848 • ACR/ARHP Annual Meeting 2016
Adenosine A2A Receptor (A2AR) Stimulates Collagen Type III Synthesis Via β-Catenin Activation in Vitro and in Vivo
Jin Zhang¹, Gibran Shaikh², Carmen Corciulo³, Tuere Wilder³, Miguel Perez-Aso¹, Aranzazu Mediero¹ and Bruce Cronstein¹, ¹Medicine, Division of Rheumatology, NYU School of Medicine, New York, NY, ²Department of Medicine, NYU School of Medicine, New York, NY, ³Department of Medicine, Division of Rheumatology, NYU School of Medicine, New York, NY
Background/Purpose: Fibrosis of skin and other organs is a hallmark of Scleroderma. We and others have previously reported that A2AR plays a role in skin…