Abstracts tagged "collagen and fibroblasts"

Abstract Number: 935 • 2013 ACR/ARHP Annual Meeting
Adenosine A2A Receptor Activates The Pro-Fibrotic Wnt / β-Catenin Signaling In Human Dermal Fibroblasts
Miguel Perez-Aso¹ and Bruce N. Cronstein², ¹Department of Translational Medicine, New York University School of Medicine, New York, NY, ²Internal Medicine, NYU School of Medicine, Division of Rheumatology, New York, NY
Background/Purpose: Upon adenosine formation in stress conditions, the adenosine A2A Receptor (A2AR) activation promotes wound healing, but it is also detrimental in fibrotic conditions such…
Abstract Number: 820 • 2013 ACR/ARHP Annual Meeting
CC-220: A Clinical Stage Immunomodulatory, Antifibrotic Drug For Systemic Sclerosis
Jörg HW Distler¹, Yongqing Wang², Pawel Zerr³, Katrin Palumbo⁴, Gerald Horan⁵, Peter Schafer⁵ and Bashar Kahaleh⁶, ¹Department of Internal Medicine, Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany, ²Medicine, University of Toledo, Toledo, OH, ³Department of Internal Medicine III and Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany, ⁴Department of Internal Medicine 3 and Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany, ⁵Department of Translational Development, Celgene Corporation, Summit, NJ, ⁶Medicine/Rheumatology, University of Toledo, Toledo, OH
Background/Purpose: Systemic Sclerosis (SSc) is an autoimmune fibrotic disease in which B cells may play a crucial role in pathogenesis. CC-220 is an immunomodulatory drug…

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