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Abstracts tagged "co-stimulation and mouse model"

  • Abstract Number: 1760 • ACR/ARHP Annual Meeting 2015

    PD-1 Signaling Interferes with OX40 to Alter the Suppressive Function and Proliferation of CD4+ Regulatory T Cells in Lupus Mice

    Maida Wong1 and Bevra H. Hahn2,3, 1Division of Rheumatology, Department of Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, 2Medicine, UCLA David Geffen School of Medicine, Division of Rheumatology, Los Angeles, CA, 3Rheumatology, Professor Emeritus, Department of Medicine/Rheumatology, David Geffen School of Medicine UCLA, Los Angeles, CA

    Background/Purpose: In systemic lupus erythematosus (SLE), the dysregulated production of autoantibodies is a consequence of disrupted T cell homeostasis. Programmed death-1 (PD1), a negative regulatory…

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