ACR Meeting Abstracts

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Abstracts tagged "CLK/DYRK inhibitor"

  • Abstract Number: 0941 • ACR Convergence 2021

    Lorecivivint (SM04690), an Intra-articular, Small-Molecule CLK/DYRK Inhibitor That Modulates the Wnt Pathway, Provided Cartilage-Protective Effects in an Animal Model of Post-traumatic OA

    Timothy Seo1, Vishal Deshmukh1 and Yusuf Yazici2, 1Biosplice Therapeutics, Inc., San Diego, CA, 2New York University School of Medicine, La Jolla, CA

    Background/Purpose: Osteoarthritis (OA) is characterized by increased cartilage thinning, bone remodeling, and inflammation. Post-traumatic OA, which develops after acute direct trauma to the joints, accounts…
  • Abstract Number: 1469 • ACR Convergence 2021

    Lorecivivint (SM04690), an Intra-articular, Small-Molecule CLK/DYRK Inhibitor That Modulates the Wnt Pathway, as a Potential Treatment for Meniscal Injuries

    Timothy Seo1, Vishal Deshmukh1 and Yusuf Yazici2, 1Biosplice Therapeutics, Inc., San Diego, CA, 2New York University School of Medicine, La Jolla, CA

    Background/Purpose: Meniscal injuries are the most common pathology of the knee and are associated with pain, stiffness, and localized swelling. Meniscal damage is a frequent…
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