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Abstracts tagged "clinical trials and monoclonal antibodies"

  • Abstract Number: 2563 • 2019 ACR/ARP Annual Meeting

    PK/PD, Safety and Exploratory Efficacy of Subcutaneous Anifrolumab in SLE: A Phase-II Study in Interferon Type I High Patients with Active Skin Disease

    Ian Bruce1, Alireza Nami 2, Erik Schwetje 3, M Edward Pierson 4, Yen Lin Chia 5, Denison Kuruvilla 5, Gabriel Abreu 6, Raj Tummala 3 and Catharina Lindholm 6, 1University of Manchester, Manchester, United Kingdom, Manchester, England, United Kingdom, 2Joint & Muscle Medical Care, Charlotte, NC, US, Charlotte, NC, 3AstraZeneca, Gaithersburg, MD, USA, Gaithersburg, MD, 4AstraZeneca, Gaithersburg, MD, US, Gaithersburg, MD, 5AstraZeneca, South San Francisco, CA, US, South San Francisco, CA, 6AstraZeneca, Gothenburg, Sweden, Gothenburg, Sweden

    Background/Purpose: Anifrolumab, a fully human anti–IFN Type I receptor mAb, is under investigation for the treatment of SLE at a dose of 300 mg intravenously…
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