ACR Meeting Abstracts

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Abstracts tagged "clinical trials and lipids"

  • Abstract Number: 943 • 2019 ACR/ARP Annual Meeting

    A Phase 1b/2a Trial of Tofacitinib, an Oral Janus Kinase Inhibitor, in Systemic Lupus Erythematosus

    Sarfaraz Hasni1, Sarthak Gupta 2, Michael Davis 3, Elaine Poncio 4, Yenealem Temesgen-Oyelakin 4, Phillip Carlucci 4, Xinghao Wang 4, Mohammad Naqi 4, Martin Playford 5, Rishi Goel 4, Xiaobai Li 6, Ann Biehl 4, Isabel Ochoa-Navas 4, Zerai Manna 4, Yinghui Shi 7, Don Thomas 8, Jinguo Chen 9, Angélique Biancotto 9, Richard Apps 9, Foo Cheung 9, Yuri Kotliarov 9, Ashley Babyak 6, Katie Stagliano 9, John Tsang 9, Wanxia Tsai 10, Laura Vian 10, Nathalia Gazaniga 4, Valentina Giudice 4, Stephen Brooks 11, Meggan Mackay 12, Peter Gregersen 13, Betty Diamond 14, Nehal Mehta 15, Alan Remaley 5, John O'Shea 16, Massimo Gadina 10 and Mariana Kaplan 16, 1National Institute of Arthritis, Musculoskeletal, and Skin diseases/ National Institutes of Health, Bethesda, MD, 2Systemic Autoimmunity Branch, NIAMS, NIH, Bethesda, 3NIAMS/NIH, Bethesda, MD, 4NIAMS/NIH, Bethesda, 5NHLBI/NIH, Bethesda, 6Clinical Center/NIH, Bethesda, 7Office of Clinical Director, NIAMS, NIH, Bethesda, MD, 8Walter Reed National Military Medical Center, Bethesda, MD, 9NIAID/NIH, Bethesda, 10Translational Immunology Section, NIAMS, NIH, Bethesda, MD, 11Biomining and Discovery Section/NIAMS/NIH, Bethesda, MD, 12Feinstein Institute for Medical Research, New York, 13Feinstein Institutes for Medical Research, Manhasset, NY, 14Feinstein Institutes of Medical Research, Manhasset, NY, 15National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD, USA, Bethesda, MD, 16National Institute of Arthritis, Musculoskeletal, and Skin diseases/ National Institutes of Health, Bethesda

    Background/Purpose: A pharmacologic intervention that modulates JAK/STAT signaling pathways represents a novel approach for the treatment of Systemic Lupus Erythematosus (SLE). In animal models of…
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