Abstracts tagged "Clinical Response and ankylosing spondylitis (AS)"

Abstract Number: 974 • 2015 ACR/ARHP Annual Meeting
Secukinumab Significantly Improves Signs and Symptoms of Active Ankylosing Spondylitis: 52-Week Results from a Randomized, Double-Blind, Placebo-Controlled Phase 3 Trial with Subcutaneous Loading and Maintenance Dosing
Juergen Braun¹, Atul A. Deodhar², Joachim Sieper³, Maxime Dougados⁴, Brian Porter⁵, Mats Andersson⁶ and Hanno Richards⁶, ¹Rheumazentrum Ruhrgebiet, Herne, Germany, ²Division of Arthritis & Rheumatic Diseases, Oregon Health & Science University, Portland, OR, ³University Clinic Benjamin Franklin, Berlin, Germany, ⁴Université Paris René Descartes and Hôpital Cochin, Paris, France, ⁵Novartis Pharmaceuticals Corporation, East Hanover, NJ, ⁶Novartis Pharma AG, Basel, Switzerland
Background/Purpose: In MEASURE 2 (NCT01649375), subcutaneous (s.c.) secukinumab, an anti–interleukin-17A antibody, improved the signs and symptoms of ankylosing spondylitis (AS) through 16 weeks (wks) of…
Abstract Number: 2896 • 2015 ACR/ARHP Annual Meeting
Secukinumab Provides Sustained Improvements in the Signs and Symptoms of Active Ankylosing Spondylitis: 2-Year Efficacy and Safety Results from a Phase 3, Randomized, Double-Blind, Placebo-Controlled Trial
Dominique Baeten¹, Jurgen Braun², Joachim Sieper³, Maxime Dougados⁴, Atul A. Deodhar⁵, Xenofon Baraliakos⁶, Brian Porter⁷, Yankun Gong⁸ and Hanno Richards⁹, ¹1Academic Medical Center / University of Amsterdam, Amsterdam, Netherlands, ²Rheumazentrum Ruhrgebiet, Herne, Germany, Herne, Germany, ³University Clinic Benjamin Franklin, Berlin, Germany, ⁴Paris-Descartes University, Paris, France, ⁵Oregon Health and Sciences University, Portland, OR, ⁶Rheumazentrum Ruhrgebiet, Herne, Germany, ⁷Novartis Pharmaceuticals Corporation, East Hanover, NJ, ⁸Beijing Novartis Pharma Co. Ltd., Beijing, China, ⁹Novartis Pharma AG, Basel, Switzerland
Background/Purpose: Secukinumab, an anti–interleukin-17A monoclonal antibody, improved the signs and symptoms of ankylosing spondylitis (AS) over 52 weeks (wks) in the randomized, double-blind, placebo (PBO)-controlled,…

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