Abstracts tagged "Classical Monocytes"

Abstract Number: 0521 • ACR Convergence 2021
Genome-Wide DNA Methylation and Gene Expression Signatures in Classical Monocytes from African Ancestry Patients with Systemic Sclerosis
Sarah Smith¹, Peter Allen², Robert Wilson¹, Jena Wirth¹, DeAnna Baker Frost¹, Gary Gilkeson¹, Melissa Cunningham¹, Devin Absher³ and Paula Ramos¹, ¹Medical University of South Carolina, Charleston, SC, ²University of Alabama at Birmingham, Birmingham, AL, ³HudsonAlpha Institute for Biotechnology, Huntsville, AL
Background/Purpose: Systemic sclerosis (SSc) is a multisystem autoimmune disorder that has an unclear etiology and disproportionately affects individuals of African ancestry (AA). Despite this, AA…
Abstract Number: 1071 • 2019 ACR/ARP Annual Meeting
A Common Transcriptional Signature Is Present in Circulating Classical Monocytes and Skin Macrophages in Systemic Sclerosis
Hadijat Makinde¹, Salina Dominguez ², Gaurav Gadhvi ³, Kathleen Aren ⁴, Chang Zeng ³, Garrett Eickelberg ³, Dinesh Khanna ⁵, Shervin Assassi ⁶, Tracy Frech ⁷, Monique Hinchcliff ⁸, Carla Cuda ⁹, Deborah Winter ² and Harris Perlman ², ¹Northwestern University, Chicago, IL, ²Northwestern University Feinberg School of Medicine, Division of Rheumatology, Chicago, ³Northwestern University, Chicago, ⁴Northwestern.edu, Chicago, ⁵Scleroderma Program, Division of Rheumatology, Department of Internal Medicine, Autoimmunity Center of Excellence, University of Michigan, Ann Arbor, ⁶Division of Rheumatology and Clinical Immunogenetics, University of Texas McGovern Medical School, Houston, Texas, USA, Houston, TX, ⁷Division of Rheumatology, University of Utah and Salt Lake VAMC, Salt Lake City, UT, ⁸Yale University, Section of Rheumatology, Allergy and Immunology, New Haven, CT, ⁹Northwestern University Feinberg School of Medicine, Division of Rheumatology, Chicago, IL
Background/Purpose: The etiology and pathogenesis of systemic sclerosis (SSc) are poorly understood; however, an increasing body of evidence supports an early inflammatory phase that precedes…

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