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Abstracts tagged "CLASI"

  • Abstract Number: 861 • ACR/ARP Annual Meeting 2019

    Cutaneous Lupus Erythematosus Disease Area & Severity Index (CLASI) Demonstrates Thresholds for Detection of Treatment Response in a Phase-2, Placebo-Controlled Trial of Ustekinumab in SLE

    Victoria Werth1, Bevra Hahn 2, George Tsokos 3, Shawn Rose 4, Kaiyin Fei 4, Yun Gregan 4, Robert Gordon 4, Kim Hung Lo 4 and Ronald van Vollenhoven 5, 1Hospital of the Univ of PA and Veteran’s Administration Med Center, Philadelphia, PA, 2University of California, Los Angeles, CA, 3Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, 4Janssen Research & Development, LLC, Spring House, PA, 5Amsterdam Rheumatology and Immunology Center, Amsterdam, Netherlands

    Background/Purpose: Ustekinumab (UST), an anti-IL-12/23 p40 monoclonal antibody, showed significantly greater improvement at week (wk) 24 compared with placebo (PBO) in Systemic Lupus Erythematosus Disease…

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