Abstracts tagged "citrulline and rheumatoid arthritis (RA)"

Abstract Number: 2046 • 2018 ACR/ARHP Annual Meeting
Serum Immunoglobulin G Targets Citrulline-Containing Immunoglobulin G Peptides in Rheumatoid Arthritis Patients Who Test Positive for Rheumatoid Factor and Anti-Cyclic Citrullinated Peptide Antibodies
Mandar Bawadekar¹, Zihao Zheng², Alan J. Bridges^3,4, Michael A. Newton⁵ and Miriam A. Shelef^1,4, ¹Department of Medicine, Division of Rheumatology, University of Wisconsin - Madison, Madison, WI, ²Departments of Statistics, University of Wisconsin - Madison, Madison, WI, ³Medicine, University of Wisconsin - Madison, Madison, WI, ⁴William S. Middleton Memorial Veterans Hospital, Madison, WI, ⁵Departments of Statistics and of Biostatistics and Medical Informatics, University of Wisconsin - Madison, Madison, WI
Background/Purpose: Rheumatoid arthritis patients produce a variety of anti-citrullinated protein antibodies (ACPAs) as well as antibodies that bind homocitrullinated and malondialdehyde-acetaldehyde adducted proteins leading to…
Abstract Number: 1549 • 2016 ACR/ARHP Annual Meeting
Rheumatoid Arthritis and Periodontal Disease: Salivary ACPA Levels and Clinical Presentation
Zoltan Szekanecz¹, Ildiko Tar², Eva Csösz³, Eva Veiszenbacher⁴, Edit Végh⁵, Kinga Bágyi⁶, Karin Lundberg⁷, Nastya Kharlamova⁸ and Ildiko Márton², ¹Department of Rheumatology, University of Debrecen Faculty of Medicine, Debrecen, HU, ²Department of Periodontology, University of Debrecen Faculty of Dentistry, Debrecen, Hungary, ³Center for Molecular Medicine, University of Debrecen Faculty of Medicine, Debrecen, Hungary, ⁴Faculty of Dentistry, University of Tirgu Mures, Tirgu Mures, Romania, ⁵Department of Rheumatology, University of Debrecen Faculty of Medicine, Debrecen, Hungary, ⁶Department of Restorative Dentistry, University of Debrecen Faculty of Dentistry, Debrecen, Hungary, ⁷Rheumatology unit, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden, ⁸Rheumatology Unit, Department of Medicine, Solna, Karolinska Institute, Stockholm, Sweden
Background/Purpose: We evaluated the periodontal involvement of rheumatoid arthritis (RA) patients, and we correlated with various laboratory biomarkers including lipids, autoantibodies, serum vitamin D levels,…
Abstract Number: 1770 • 2012 ACR/ARHP Annual Meeting
Recognition of Citrullinated and Carbamylated Proteins by Human Antibodies: Specificity, Cross-Reactivity and the “AMC-Senshu” Method
Jing Shi¹, George Janssen², Peter van Veelen², Janwouter Drijfhout², Antony Cerami³, Tom Huizinga⁴, Leendert A. Trouw⁵ and René E.M. Toes⁴, ¹Rheumatology, LUMC, Leiden, Netherlands, ²Immunohematology and Bloodbank, LUMC, Leiden, Netherlands, ³Nephrology, LUMC, Leiden, Netherlands, ⁴Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ⁵Rheumatology, Leiden University Medical Centre, Leiden, Netherlands
Background/Purpose: Anti-citrullinated protein antibodies (ACPA) play an important role in the diagnosis and prognosis of Rheumatoid Arthritis (RA). The Anti-Modified Citrulline (AMC) (‘Senshu’) method is…
Abstract Number: 1689 • 2012 ACR/ARHP Annual Meeting
Anti-Peptidylarginine Deiminase 3/4 Cross-Reactive Antibodies: A Novel Biomarker with Clinical and Mechanistic Implications in Rheumatoid Arthritis
Erika Darrah¹, Jon T. Giles², Herbert Bull³, Felipe Andrade⁴ and Antony Rosen¹, ¹Division of Rheumatology, Johns Hopkins University, Baltimore, MD, ²Division of Rheumatology, Columbia University, College of Physicians & Surgeons, New York, NY, ³Consultant, Westfield, NJ, ⁴Division of Rheumatology, Division of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD
Background/Purpose: Peptidylarginine deiminases (PADs) have emerged as key participants in the pathogenesis of rheumatoid arthritis (RA) due to their expression in inflamed RA synovium and…
Abstract Number: 1190 • 2012 ACR/ARHP Annual Meeting
Fine Specificity of Anti-Citrullinated Peptide Antibodies Discloses a Heterogeneous Antibody Population in Rheumatoid Arthritis (RA)
John D. Goules, Andreas V. Goules and Athanasios G. Tzioufas, Pathophysiology, School of Medicine, National University of Athens, Athens, Greece
Background/Purpose: Anti-citrullinated protein antibodies (ACPA) are highly specific for the diagnosis of patients with RA. However, the predominant B cell epitopes have not yet been…
Abstract Number: 436 • 2012 ACR/ARHP Annual Meeting
Synthetic Anti-CCP Antibody Aggravated Severity of Animal Arthritis and Captured Citrullinated Antigen in the Serum of Patients with Rheumatoid Arthritis
Youngkyun Kim¹, Su-Jin Moon², Hyoju Yi² and Ji Hyeon Ju³, ¹1Convergent Research Consortium for Immunologic Disease, The Catholic University of Korea, Seoul, South Korea, ²Rheumatology, College of Medicine, The Catholic University of Korea, Seoul, South Korea, ³Rheumatology, College of Medicine, The Catholic University of Korea & Stanford University, Seoul & Palo Alto, CA
Background/Purpose: Auto-antibodies against citrullinated protein antigens (ACPA) have shown their relevance for the prognosis and diagnosis of rheumatoid arthritis (RA), and have been implicated in…
Abstract Number: 422 • 2012 ACR/ARHP Annual Meeting
Antibodies to Citrulline From Rheumatoid Arthritis Patients Also Bind Homocitrulline
Mathias Scinocca¹, Radha Joseph², David A. Bell³, Ewa Cairns³ and Lillian J. Barra³, ¹Microbiology and Immunology, Schulich School of Medicine and Dentistry, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada, ²Microbiology and Immunology, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada, ³Medicine, Division of Rheumatology, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada
Background/Purpose: Antibodies to citrullinated proteins/peptides (ACPA) are specific for Rheumatoid Arthritis (RA). One of ACPA’s targets is citrullinated fibrinogen (citfib) and it is found in…

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