Abstracts tagged "Citrulline and osteoclastogenesis"

Abstract Number: 1188 • 2012 ACR/ARHP Annual Meeting
Fibrinogen Induced Inhibition of Osteoclastogenesis Is Reversed by Citrullination of Fibrinogen by Peptidylarginine Deiminase
Eun Young Lee¹, Ji Soo Kim², Hye Won Kim³, Sung Hae Chang⁴, Jin-Su Song⁵, Hie-Joon Kim⁵, Kyung-Hyun Park-Min⁶, Lionel B. Ivashkiv⁷, Eun Bong Lee⁸ and Yeong Wook Song⁹, ¹Division of Rheumatology, Department of Internal Medicine, Seoul National University College of Medicine, Seoul, South Korea, ²Seoul National University College of Medicine, Seoul, South Korea, ³Rheumatology, Seoul National University College of Medicine, Seoul, South Korea, ⁴Internal Medicine, Seoul National University College of Medicine, Seoul, South Korea, ⁵Department of Chemistry, Seoul National University, Seoul, South Korea, ⁶Rheumatology, Hospital for Special Surgery, New York, NY, ⁷Arthritis and Tissue Degeneration Program and the David Z. Rosensweig Genomics Research Center, Hospital for Special Surgery, New York, NY, ⁸Seoul National University, Seoul, South Korea, ⁹Division of Rheumatology, Department of Internal Medicine,, Seoul National University College of Medicine, Seoul, South Korea
Background/Purpose: There are increasing evidences that autoantibodies and immune complexes (ICs) containing citrullinated fibrinogen are present in rheumatoid arthritis (RA) patients' sera and contribute to…