Abstracts tagged "chondroitin"

Abstract Number: 1361 • 2018 ACR/ARHP Annual Meeting
Predictive Modeling of Therapeutic Response in Knee Osteoarthritis
Valentina Calamia¹, Florencia Picchi¹, Ignacio Rego-Pérez², Maria Camacho¹, Lucia González¹, Patricia Fernández³, Marta Herrero⁴, Helena Martinez⁴, Josep Vergés⁵, Cristina Ruiz-Romero⁶ and Francisco J Blanco⁷, ¹Rheumatology Research Group, Proteomics Unit-ProteoRed/ISCIII, INIBIC-CHUAC, A Coruña, Spain, ²Rheumatology Research Group, Genomic Unit, INIBIC-CHUAC, A Coruña, Spain, ³Proteomics group, Rheumatology Division, ProteoRed, PRB2-ISCIII. INIBIC-Hospital Universitario A Coruña, La Coruña, Spain, ⁴Clinical R&D Area, Bioiberica, SAU, Barcelona, Spain, ⁵Osteoarthritis Foundation International, Barcelona, Spain, ⁶Rheumatology Division, ProteoRed, PRB2-ISCIII. INIBIC-Hospital Universitario A Coruña, A Coruña, Spain, ⁷Rheumatology Divison, INIBIC-Hospital Universitario A Coruña, A Coruña, Spain
Background/Purpose: Phenotype identification in knee osteoarthritis (KOA) population could be useful for predicting drug response, allowing personalized interventions. In order to optimize therapeutic outcome in…
Abstract Number: 1190 • 2017 ACR/ARHP Annual Meeting
Orosomucoid 2 Serves As Predictor of Therapeutic Response in Osteoarthritis Patients Treated with Chondroitin Sulfate/Glucosamine Hydrochloride
Valentina Calamia¹, M Camacho¹, Ignacio Rego-Pérez¹, L González¹, P Fernández-Puente¹, F Picchi¹, Marta Herrero², Helena Martinez², C Ruiz-Romero¹ and Francisco J Blanco^3,4, ¹Instituto de Investigación Biomédica de A Coruña (INIBIC), A Coruña, Spain, ²Clinical R&D Area, Bioiberica, SAU, Barcelona, Spain, ³RIER-RED de Inflamación y Enfermedades Reumáticas, INIBIC-CHUAC, A Coruña, Spain, A Coruña, Spain, ⁴Rheumatology Division, ProteoRed/ISCIII, Proteomics Group, INIBIC-Hospital Universitario A Coruña, A Coruña, Spain
Orosomucoid 2 Serves as Predictor of Therapeutic Response in Osteoarthritis Patients Treated with Chondroitin Sulfate/Glucosamine HydrochlorideV. Calamia, M. Camacho, I. Rego-PŽrez, L. Gonz‡lez, P. Fern‡ndez-Puente,…
Abstract Number: 1203 • 2017 ACR/ARHP Annual Meeting
Differences in Serum Protein Biomarkers between Combined Glucosamine and Chondroitin Versus Celecoxib Treatment in a Randomized, Double-Blind Trial in Osteoarthritis Patients
Sandi L Navarro¹, Marta Herrero², Helena Martinez², Jon Ladd¹, Yuzheng Zhang¹, Edward Lo¹, David Shelley¹, Timothy W Randolph¹, Yvonne Schwarz¹, Johanna W Lampe¹ and Paul D Lampe¹, ¹Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, ²Clinical R&D Area, Bioiberica, SAU, Barcelona, Spain
Background/Purpose: Non-steroidal anti-inflammatory drugs, e.g., celecoxib, are commonly used for inflammatory conditions, including osteoarthritis (OA), but are associated with adverse effects. Combined glucosamine hydrochloride plus…
Abstract Number: 1208 • 2017 ACR/ARHP Annual Meeting
Levels of Serum Biomarkers from a Two-Year Multicentre Trial Are Associated with Treatment Response on Knee Osteoarthritis Cartilage Loss As Assessed By MRI: An Exploratory Study
Johanne Martel-Pelletier¹, Jean-Pierre Raynauld¹, François Mineau¹, François Abram², Patrice Paiement³, Philippe Delorme³ and Jean-Pierre Pelletier¹, ¹Osteoarthritis Research Unit, University of Montreal Hospital Research Centre (CRCHUM), Montreal, QC, Canada, ²Medical Imaging Research & Development, ArthroLab Inc., Montreal, QC, Canada, ³ArthroLab Inc., Montreal, QC, Canada
Background/Purpose: There is an obvious need to identify biomarkers that could predict patient response to an osteoarthritis (OA) treatment. This post hoc study explored in…
Abstract Number: 2231 • 2014 ACR/ARHP Annual Meeting
Combined Chondroitin Sulfate and Glucosamine Is Comparable to Celecoxib for Painful Knee Osteoarthritis. Results from a Multicenter, Randomized, Double-Blind, PHASE IV NON-Inferiority TRIAL
Marc Hochberg¹, Johanne Martel-Pelletier², Jordi Monfort³, Ingrid Moller⁴, Juan Ramon Castillo⁵, Nigel K. Arden^6,7,8, Francis Berenbaum^9,10, Jean-Pierre Pelletier¹¹, Francisco J. Blanco¹², Philip G. Conaghan¹³, Yves Henrotin^14,15, Thomas Pap¹⁶, Pascal Richette^17,18,19, Allen Sawitzke²⁰, Patrick du Souich²¹ and Moves Investigation Group²², ¹University of Maryland School of Medicine, Baltimore, MD, ²Osteoarthritis Research Unit CR-CHUM, Notre-Dame Hospital 1560 Sherbrooke St East, Montreal, QC, Canada, ³Department of Rheumatology, Grup de recerca cel•lular en inflamació i cartílag. IMIM (Institut de Recerca Hospital del Mar), Barcelona, Spain, ⁴Instituto Poal, Barcelona, Spain, ⁵Head of Clinical Pharmacology Unit Hospital Universitario Virgen del Rocío, Sevilla, Spain;, Sevilla, Spain, ⁶NIHR Musculoskeletal Biomedical Research Unit, University of Oxford, Oxford, United Kingdom, ⁷Arthritis Research UK (ARUK), Center for Sports, Exercise and Osteoarthritis, University of Oxford, Nuffield Orthopaedic Centre, Oxford, United Kingdom, ⁸MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton, United Kingdom, ⁹Sorbonne University, INSERM UMR S938, UPMC, University of Paris 06, DHU i2B, Paris, France, ¹⁰Department of Rheumatology, Assistance Publique – Hôpitaux de Paris, Saint-Antoine Hospital, Paris, France, ¹¹Osteoarthritis Research Unit, University of Montreal Hospital Research Centre (CRCHUM), Notre-Dame Hospital, Montreal, QC, Canada, ¹²Rheumatology Service, INIBIC-Hospital Universitario A Coruña, A Coruña, Spain, ¹³University of Leeds, Leeds, United Kingdom, ¹⁴Physical Therapy and Rehabilitation Department, Princess Paola Hospital, Marche-en-Famenne, Belgium, ¹⁵Bone and Cartilage Research Unit, Arthropôle Liège, University of Liège, Institute of Pathology, CHU Sart-Tilman, Liege, Belgium, ¹⁶Institute of Experimental Muskuloskeletal Medicine University Hospital Münster, Münster, Germany, ¹⁷Université Paris Diderot, UFR médicale, Paris, France, ¹⁸INSERM 1132, Université Paris-Diderot, Hôpital Lariboisière, Paris, France, ¹⁹2 Rue Ambroise Pare, Hopital Lariboisiere, Paris, France, ²⁰Rheumatology, University of Utah Medical Center, Salt Lake City, UT, ²¹Department of Pharmacology, Faculty of Medicine, University of Montreal, Montreal, QC, Canada, ²²Spain, Germany, France and Poland, Barcelona, Spain
Background/Purpose The Multicentre Osteoarthritis interVEntion trial with Sysadoa (MOVES) compared efficacy and safety of Chondroitin sulfate (CS) and Glucosamine Hydrochloride (GH) with that of Celecoxib…
Abstract Number: 2250 • 2014 ACR/ARHP Annual Meeting
The Effects of Treatment on Disease Symptoms and Progression of Structural Changes in Knee Osteoarthritis Participants from the Osteoarthritis Initiative Progression Cohort
Jean-Pierre Pelletier¹, Camille Roubille¹, François Abram², Marc Dorais³, Philippe Delorme¹, Jean-Pierre Raynauld¹ and Johanne Martel-Pelletier¹, ¹Osteoarthritis Research Unit, University of Montreal Hospital Research Centre (CRCHUM), Montreal, QC, Canada, ²Medical Imaging Research & Development, ArthroLab Inc., Montreal, QC, Canada, ³StatSciences Inc., Notre-Dame de l’Île-Perrot, QC, Canada
Background/Purpose: In the perspective of personalized management of osteoarthritis (OA), a clinically relevant concern is the impact of meniscal extrusion on response to treatment. This study evaluated the role…
Abstract Number: 171 • 2013 ACR/ARHP Annual Meeting
Effects Of Chondroitin Sulfate On The Gene Expression Profile In The Inflamed Synovial Membrane
Cécile Lambert¹, Jean-Emile Dubuc², Eulalia Montell³, Josep Verges³ and Yves Henrotin¹, ¹University of Liège, Bone and Cartilage Research Unit, Liège, Belgium, ²Clinical University Saint Luc, Orthopaedic Department, Bruxelles, Belgium, ³Pre-Clinical R&D Area, Pharmascience Division, BIOIBERICA S.A., Barcelona, Spain
Background/Purpose: Chondroitin sulfate (CS) is one the most used molecules in the management of OA. Its mechanism of action remains to be detailed. The aim…
Abstract Number: 2145 • 2013 ACR/ARHP Annual Meeting
Impact On Cartilage Volume Changes Over Time Of Conventional Treatment and Of Glucosamine and Chondroitin Sulfate In Knee Osteoarthritis Patients: Data From The Osteoarthritis Initiative Cohort
Johanne Martel-Pelletier¹, Camille Roubille¹, Jean-Pierre Raynauld¹, François Abram², Pierre Dodin³, Marc Dorais⁴, Philippe Delorme¹ and Jean-Pierre Pelletier¹, ¹Osteoarthritis Research Unit, University of Montreal Hospital Research Centre (CRCHUM), Montreal, QC, Canada, ²Medical Imaging Research & Development, ArthroLab Inc., Montreal, QC, Canada, ³Imaging Research & Development, ArthroLab Inc., Montreal, QC, Canada, ⁴StatSciences Inc., Notre-Dame de l’Île Perrot, QC, Canada
Background/Purpose: To explore, using data from participants enrolled in the progression cohort of the Osteoarthritis Initiative (OAI), the effects of conventional knee osteoarthritis (OA) pharmacological…
Abstract Number: 2146 • 2013 ACR/ARHP Annual Meeting
Effects Of Chondroitin Sulfate On Brain Response To Painful Stimulation In Knee Osteoarthritis Patients: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial
Jordi Monfort¹, Jesús Pujol², O Contreras-Rodriguez², Jone Llorente-Onaindia², M López-Solà², Laura Blanco-Hinojo², J Deus², H Ortiz², Francisco Montañés³, M Campillo², Pere Benito², Laura Sánchez⁴, Marta Herrero⁵ and Josep Vergés⁶, ¹Reumatologia, Hospital del Mar, Barcelona, Spain, ²Hospital del Mar, Barcelona, Spain, ³Rhaumatology, Hospital del Mar, Barcelona, Spain, ⁴Bioiberica, Barcelona, Spain, ⁵Pharmascience Division, Bioiberica S.A., Barcelona, Spain, ⁶Pre-Clinical R&D Area, Pharmascience Division, BIOIBERICA S.A., Barcelona, Spain
Background/Purpose: Knee osteoarthritis (OA) is a degenerative joint disease causing symptoms in 12% of people over the age of 65 . A variety of treatments…
Abstract Number: 2113 • 2013 ACR/ARHP Annual Meeting
Glucosamine–Chondroitin Sulfate Reduces Pain, Disability and Non-Steroidal Anti-Inflammatory Drug consumption In Patients With Chronic Low Back Pain: A Large, Community-Based, Pilot, Open Prospective Study
Gurkirpal Singh^1,2, Liudmila Alekseeva³, Valeriy Alekseev⁴ and Evgeny Nasonov⁵, ¹ICORE, Woodside, CA, ²Gastroenterology/Hepatology, Stanford University School of Medicine, Palo Alto, CA, ³State Institute of Rheumatology of Russian Academy of Medical Sciences, Moscow, Russia, ⁴Department of Nervous Diseases, First Moscow State Medical University, Moscow, Russia, ⁵State NII of Rheumatology of Russian Academy of Sciences, Moscow, Russia
Background/Purpose: The Global Burden of Diseases, Injuries, and Risk Factors Study 2010 identified low back pain as the leading cause of Years Lived with Disability…
Abstract Number: 858 • 2013 ACR/ARHP Annual Meeting
Monosodium Urate Crystal Induced Macrophage Inflammation Is Attenuated By Chondroitin Sulfate: Pre-Clinical Model For Gout Prophylaxis?
Eric W. Orlowsky¹, Thomas V. Stabler², Eulalia Montell³, Josep Verges³ and Virginia B. Kraus², ¹Divsion of Rheumatology, Dept of Internal Medicine, Duke University Medical Center, Durham, NC, ²Medicine/Rheumatology, Duke University Medical Center, Durham, NC, ³Pre-Clinical R&D Area, Pharma Science Division, Bioibérica, Barcelona, Spain
Background/Purpose: Gout is one of the most common forms of inflammatory arthritis and is characterized by acute episodes of joint pain. Monosodium urate (MSU) crystals…
Abstract Number: 169 • 2013 ACR/ARHP Annual Meeting
Effects Of Chondroitin Sulfate On The Gene Expression Profile In Interleukin-1β Stimulated Synovial Fibroblast Cells Cultures
Cécile Lambert¹, Jean-Emile Dubuc², Eulalia Montell³, Josep Verges³ and Yves Henrotin¹, ¹University of Liège, Bone and Cartilage Research Unit, Liège, Belgium, ²Clinical University Saint Luc, Orthopaedic Department, Bruxelles, Belgium, ³Pre-Clinical R&D Area, Pharmascience Division, BIOIBERICA S.A., Barcelona, Spain
Background/Purpose: Chondroitin sulfate (CS) is one the most used molecules in the management of OA. Its mechanism of action remains to be detailed. In this…
Abstract Number: 1124 • 2012 ACR/ARHP Annual Meeting
Total Knee Replacement As an Osteoarthritis Study Outcome: Predictors Derived From Long-Term Observation Following a Randomized Clinical Trial
Jean-Pierre Raynauld¹, Johanne Martel-Pelletier¹, Marc Dorais², Boulos Haraoui¹, Denis Choquette¹, François Abram³, André Beaulieu⁴, Louis Bessette⁵, Frédéric Morin⁶, Lukas M. Wildi¹ and Jean Pierre Pelletier⁷, ¹Osteoarthritis Research Unit, University of Montreal Hospital Research Centre (CRCHUM), Montreal, QC, Canada, ²StatSciences Inc., Notre-Dame de l’Île Perrot, QC, Canada, ³Medical Imaging Research & Development, ArthroLab Inc., Montreal, QC, Canada, ⁴Faculty of Medicine, Laval University, Quebec, QC, Canada, ⁵Centre Hospitalier Universitaire de Québec, pavillon CHUL, Sainte-Foy, QC, Canada, ⁶Centre de Recherche Musculo-squelettique, Trois-Rivières, QC, Canada, ⁷Osteoarthritis Research Unit, University of Montreal Hospital Research Centre (CRCHUM), Notre-Dame Hospital, Montreal, QC, Canada
Background/Purpose: Using data from a 4-year follow-up of knee OA patients who formerly received treatment with chondroitin sulfate (CS) within a 6-month clinical trial, we…
Abstract Number: 1135 • 2012 ACR/ARHP Annual Meeting
Combined Glucosamine and Chondroitin Sulfate, Once of Three Times Daily, Provide Clinically Relevant Analgesia in Knee Osteoarthritis
Jose R. Provenza¹, Samuel K. Shinjo², Joyce M. Silva³, Carla RGS. Peron⁴ and Francisco AC Rocha⁵, ¹Rheumatology, Pontifícia Universidade Católica de Campinas, Campinas, Brazil, ²Rheumatology Division, Faculdade de Medicina da Universidade de São Paulo, Sao Paulo, Brazil, ³Clinical Research, Sao Paulo, Brazil, ⁴Clinical Research, Laboratórios Aché Ltda, Sao Paulo, Brazil, ⁵Rheumatology, Brazilian Registry of Spondyloarthritis, São Paulo, Brazil
Background/Purpose: The analgesic efficacy of combined glucosamine and chondroitin sulfate (CS) in knee osteoarthritis (OA) remains controversial. Criticism to previous studies includes small sample size,…
Abstract Number: 1101 • 2012 ACR/ARHP Annual Meeting
Condroitin Sulfate Decreases Chemokine Levels and Synovitis in knee osteoarthritis Patients
Jordi Monfort¹, Paula Escudero², Cristobal Orellana³, Laura Piqueras⁴, Laura Tio⁵, Francisco Montañés⁶, Natalia García⁷, Chantal Company², Pere Benito⁸ and Maria Jesús Sanz², ¹Reumatologia, Hospital del Mar, Barcelona, Spain, ²Pharmacology, Universitary Clinic Hospital Research Foundation-INCLIVA, University of Valencia, Valencia, Spain, ³Rheumatology, Corporació Sanitaria Parc Taulí, Sabadell, Spain, ⁴University Clinic Hospital Research Foundation-INCLIVA, University of Valencia, Valencia, Spain, ⁵U.R. Inflamació cel·lular i cartílag, GRICIC. FIMIM, Barcelona, Spain, ⁶Rhaumatology, Hospital del Mar, Barcelona, Spain, ⁷GRICIC. FIMIM, Barcelona, Spain, ⁸Hospital del Mar, Barcelona, Spain
Background/Purpose: Synovitis is one of the major signs of structure damage in osteoarthritis (OA) progression. Chondroitin sulfate (CS) is an effective drug in the treatment…

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