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Abstracts tagged "chondrocytes and transcription factor"

  • Abstract Number: 1260 • 2015 ACR/ARHP Annual Meeting

    Differential DNA Methylation and Reduced Expression of Transcription Factors in Human OA Cartilage

    Oscar Alvarez-Garcia1, Kathleen M. Fisch1, Ryuichiro Akagi2,3, Masahiko Saito4, Takahisa Sasho4, Andrew I. Su5 and Martin K. Lotz6, 1The Scripps Research Institute, La Jolla, CA, 2The Scripps Research Institute, San Diego, CA, 3Department of Orthopaedic Surgery, School of Medicine, Chiba University, Chiba, Japan, 4Orthopaedic Surgery, Chiba University, Chiba, Japan, 5Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA, 6Division of Arthritis, The Scripps Research Institute, La Jolla, CA

    Background/Purpose: DNA methylation is the most characterized epigenetic mechanism and has been recently linked to knee osteoarthritis (OA) pathogenesis. The present study was design to…
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