ACR Meeting Abstracts

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Abstracts tagged "chondrocytes and osteoarthritis"

  • Abstract Number: 2000 • 2018 ACR/ARHP Annual Meeting

    Interleukin-1β, Oxidative Stress and Basic Calcium Phosphate Crystals Induce Osteoarthritis-like Changes in Chondrocyte Phenotype By Altering the Expression of PERIOD2, a Core Component of the Chondrocyte Circadian Clock

    Jing Rong1, Mark Zhu2, Jacob Munro3, Geraldine M. McCarthy4, Jillian Cornish5, Nicola Dalbeth1 and Raewyn Poulsen2, 1University of Auckland, Auckland, New Zealand, 2Medicine, University of Auckland, Auckland, New Zealand, 3Orthopaedics, Auckland City Hospital, Auckland, New Zealand, 4Mater Misericordiae University Hospital, Dublin, Ireland, 5Department of Medicine, University of Auckland, Auckland, New Zealand

    Background/Purpose: Almost all cells contain a circadian clock. Cell clocks are key regulators of cell activity and cell differentiation. In osteoarthritis (OA), chondrocytes inappropriately undergo…
  • Abstract Number: 2001 • 2018 ACR/ARHP Annual Meeting

    Adenosine A2A Receptor Stimulation Regulates Autophagy in Chondrocytes

    Benjamin Friedman1, Carmen Corciulo2, Cristina Castro3 and Bruce N. Cronstein1, 1Rheumatology, New York University School of Medicine, New York, NY, 2Department of Medicine, Division of Rheumatology, New York University School of Medicine, New York, NY, 3Medicine, NYU School of Medicine, New York, NY

    Background/Purpose: Osteoarthritis (OA) is a debilitating condition characterized by chondrocyte dysfunction and loss of cartilage. Autophagy, a homeostatic process that occurs in times of cellular…
  • Abstract Number: 1817 • 2018 ACR/ARHP Annual Meeting

    MicroRNA-128 Impairs Cartilage Integrity and Deteriorates Osteoarthritis Pathogenesis through Deregulating Chondrocyte Autophagy

    Feng-Sheng Wang1, Wei-Shiung Lian2, Yi-Chih Sun1, Jih-Yang Ko3 and Yu-Shan Chen1, 1Core Facility for Phenomics & Diagnostics, Department of Medical Research, Core Facility for Phenomics & Diagnostics, Department of Medical Research, Kaohsiung Chang Gung Memorial Hospital, Taiwan, Kaohsiung, Taiwan, 2Core Facility for Phenomics & Diagnostics, Department of Medical Research, Kaohsiung Chang Gung Memorial Hospital, Taiwan, Kaohsiung, Taiwan, 3Department of Orthopedic Surgery, Department of Orthopedic Surgery, Kaohsiung Chang Gung Memorial Hospital, Taiwan, Kaohsiung, Taiwan

    Background/Purpose: Autophagy gets rids of unwanted proteins or organelle keeping cells to stay functional upon encountering adverse stresses. While non-coding microRNAs interfere with mRNA targets…
  • Abstract Number: 1999 • 2018 ACR/ARHP Annual Meeting

    Aberrant Expression of the GluN2B N-Methyl D-Aspartate Receptor Subunit in Osteoarthritic Chondrocytes Causes Disease-Associated Changes in Chondrocyte Phenotype through Altered Expression of Core Components of the Chondrocyte Circadian Clock

    Maggie Kalev-Zylinska1, James Hearn1, Jing Rong1, Mark Zhu2, Jacob Munro3, Jillian Cornish4, Nicola Dalbeth1 and Raewyn Poulsen2, 1University of Auckland, Auckland, New Zealand, 2Medicine, University of Auckland, Auckland, New Zealand, 3Orthopaedics, Auckland City Hospital, Auckland, New Zealand, 4Department of Medicine, University of Auckland, Auckland, New Zealand

    Background/Purpose: Circadian clocks are key regulators of cell behaviour. Disruption to cell clocks is implicated in a range of diseases. Expression of two core clock…
  • Abstract Number: 904 • 2017 ACR/ARHP Annual Meeting

    Deficient Autophagy Induces Lamin a/C Accumulation in Aging and Osteoarthritis

    Paloma Lopez de Figueroa1, Uxia Nogueira-Recalde2, Fernando Osorio3, Martin Lotz4, Carlos Lopez-Otin3, Francisco J Blanco2 and Beatriz Carames1, 1Cartilage Biology Group. Rheumatology Division, INIBIC-CHUAC, A Coruña, Spain, A Coruña, Spain, 2Cartilage Biology Group. Rheumatology Division, INIBIC-CHUAC, A Coruña, A Coruña, Spain, 3Degradome Lab, Universidad de Oviedo, Oviedo, Spain, 4Department of Molecular & Experience Medicine, Scripps Research Institute, LaJolla, CA

    Background/Purpose: Autophagy, an essential chondrocyte homeostasis mechanism, is defective in Aging and Osteoarthritis (OA). However, the targets regulating this mechanism are still unknown. Here, we…
  • Abstract Number: 2124 • 2016 ACR/ARHP Annual Meeting

    Maintenance of Chondrocyte Phenotypic Stability By TRPC6 Calcium Channel Activity

    Joanna Sherwood1, Jessica Bertrand2, Francesco Dell'Accio3 and Thomas Pap4, 1Institute for Experimental Musculoskeletal Medicine, University Hospital Münster, Münster, Germany, 2Department of Orthopedic Surgery, Otto-von-Guericke University of Magdeburg, Magdeburg, Germany, 3William Harvey Research Institute,, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom, 4Institute of Experimental Musculoskeletal Medicine, University Hospital Münster, Münster, Germany

    Background/Purpose: The ELR+ CXC chemokine CXCL6 is produced by healthy articular chondrocytes and retained within the cartilage matrix via interactions with heparan sulphate proteoglycans. There,…
  • Abstract Number: 2127 • 2016 ACR/ARHP Annual Meeting

    Dicam Promotes Proliferation and Hypertrophic Differentiation of Chondrocyte through Indian Hedgehog Signaling of Primary Cilia

    Seungwoo Han1,2, Hye-Ri Park2, Min-Su Han2, Eun-Ju Lee2, Ji-Ae Jang2, Ji-Min Kim3, Gun-Woo Kim2,4 and Younkwan Jung2, 1Internal Medicine, Daegu Fatima hospital, Daegu, Korea, The Republic of, 2Fatima Research Institute, Daegu, Korea, The Republic of, 3Division of Rheumatology, Department of Internal Medicine, Dongsan Medical Center, Keimyung University School of Medicine, Daegu, Korea, The Republic of, 4Rheumatology, Daegu Fatima hospital, Daegu, Korea, The Republic of

    Background/Purpose: Chondrocytes in growth plate is known to respond to hydrostatic loading by increasing Indian hedgehog (Ihh) signaling, and that the primary cilium is required…
  • Abstract Number: 2141 • 2016 ACR/ARHP Annual Meeting

    Terminal Uridylyl Transferase ZCCHC6-Dependent Generation of miRNA Diversity in Primary Human Chondrocytes

    Abdul Haseeb1, Mohammad Shahidul Makki2, Mohammad Ansari3, Helen Piontkivska4 and Tariq M. Haqqi1, 1Anatomy & Neurobiology, Northeast Ohio Medical University, Rootstown, OH, 24209 St Rt 44 PO Box 95, Northeast Ohio Medical University, Rootstown, OH, 3Anatomy & Neurobiology, Northeast Ohio Medical University, Roostown, OH, 4Kent State University, Kent, OH

    Terminal Uridylyl Transferase ZCCHC6-dependent Generation Of miRNA Diversity In Primary Human Chondrocytes Background/Purpose: MicroRNAs (miRNAs) are a group of small, noncoding RNAs that post-transcriptionally regulate…
  • Abstract Number: 1148 • 2015 ACR/ARHP Annual Meeting

    The Role of TRPC6 in CXCR2-Mediated Chondrocyte Phenotypic Stability

    Joanna Sherwood1, Jessica Bertrand1, Francesco Dell'Accio2 and Thomas Pap3, 1Institute for Experimental Musculoskeletal Medicine, University Hospital Münster, Münster, Germany, 2EMR, Queen Mary's School of Medicine and Dentistry, London, United Kingdom, 3Institute of Experimental Musculoskeletal Medicine, University Hospital Münster, Münster, Germany

    Background/Purpose: We have recently demonstrated that ELR+ CXC chemokines signaling via the CXCR2 receptor, are produced by healthy chondrocytes and are retained within the cartilage…
  • Abstract Number: 1015 • 2014 ACR/ARHP Annual Meeting

    Mir-9/MCPIP1 Axis Mediated Regulation of IL-6 Expression in Osteoarthritis Chondrocytes

    Tariq Haqqi1, Abdul Haseeb2 and Mohammad Shahidul Makki2, 1Anatomy & Neurobiology, Northeast Ohio Medical University, Rootstown, OH, 2Anatomy and Neurobiology, Northeast Ohio Medical University (NEOMED), Rootstown, OH

    Background/Purpose Post-transcriptional regulation of cytokine expression is important for maintaining tissue integrity. MCPIP1 was identified as a novel protein, which destabilizes inflammatory cytokines mRNAs via…
  • Abstract Number: 69 • 2013 ACR/ARHP Annual Meeting

    Interconnected Cellular Projections and Gap Junctions Mediate Metabolic Coupling Between Chondrocytes Located In Different Layers Of The Tissue: Cell-To-Cell Communication In Normal and Osteoarthritic Cartilage

    Maria Dolores Mayan1,2,3, Paula Carpintero-Fernández1,2, Raquel Gago-Fuentes1,2, Patricia Fernández-Puente1, Purificacion Filgueira-Fernandez1, Noa Goyanes1, Virgin Valiunas4, Peter Brink4, Gary Goldberg5 and Francisco J. Blanco6,7, 1Osteoarticular and Aging Research Group. Rheumatology Division, Biomedical Research Center (INIBIC). Hospital Universitario A Coruña, Xubias de Arriba 84, 15006, A Coruña, Spain, 2These authors contribute equally to this work, A Coruña, Spain, 3Correspondence to: [email protected] and [email protected], A Coruña, Spain, 4Department of Physiology and Biophysics. State University of New York, Stony Brook, New York, SC, 5Department of Molecular Biology. Medical Center Drive, University of Medicine and Dentistry of New Jersey, Stratford, NJ, 6Osteoarticular and Aging Res. Lab. CIBER-BBN. INIBIC- University of A Coruña, A Coruña, Spain, 7Proteo-Red/ISCIII, Madrid, Spain

    Background/Purpose: We have recently found that articular chondrocytes from human adults contain long cytoplasmic arms that cross the extracellular matrix and physically connect two chondrocytes…
  • Abstract Number: 64 • 2013 ACR/ARHP Annual Meeting

    Fibulin-3 In Joint Aging and Osteoarthritis Pathogenesis

    Akihiko Hasegawa1,2, Tomo Yonezawa1, Noboru Taniguchi1, Koji Otabe1, Yukio Akasaki1, Tetsuya Matsukawa1, Masahiko Saito3, Masashi Neo4, Lihua Y. Marmorstein5 and Martin K. Lotz1, 1Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA, 2Orthopaedic Surgery, Osaka Medical College, Takatsuki, Osaka, Japan, 3Orthopaedic Surgery, Toho University Sakura Medical Center, Sakura, Japan, 4Department of Orthopedic Surgery, Osaka Medical College, Osaka, Japan, 5Department of Ophthalmology and Vision Science, University of Arizona, Tucson, AZ

    Background/Purpose: Osteoarthritis (OA) is the most common joint disease. Among the earliest lesions during OA development is disruption of the superficial zone (SZ) of articular…
  • Abstract Number: 59 • 2013 ACR/ARHP Annual Meeting

    Downregulated Forkhead-Box Class O Transcription Factors Attenuate Oxidative Stress Resistance In Human Chondrocytes

    Yukio Akasaki and Martin K. Lotz, Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA

    Background/Purpose: Aging-associated changes in articular chondrocytes represent a major risk factor for osteoarthritis (OA). The major signaling pathway that regulates cellular aging is the Insulin/IGF-1/Pl3k/Akt/forkhead-box…
  • Abstract Number: 42 • 2012 ACR/ARHP Annual Meeting

    Role of Stromal Cell-Derived Factor-1 Alpha Through Smad and MAPK Pathway On Endochondral Ossification

    Gunwoo Kim1, Seungwoo Han2, Younkwan Jung3, Eunju Lee3, Hyeri Park3, Shirine E. Usmani4, Veronica Ulici4 and Frank Beier4, 1Rheumatology, Fatima research institude, Daegu Fatima Hospital, Daegu, South Korea, 2Rheumatology, Fatima research institute, Daegu Fatima Hospital, Daegu, South Korea, 3Laboratory for arthritis and bone biology, Fatima research institute, Daegu Fatima Hospital, Daegu, South Korea, 4Physiology and Pharmacology, Schulich School of Medicine and Dentistry, London, ON, Canada

    Background/Purpose: The main cellular events of articular chondrocytes during osteoarthritis are a loss of the traits as permanent cartilage, and a transition to hypertrophic chondrocytes…
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