Abstracts tagged "chondrocytes and mitochondria"

Abstract Number: 1933 • ACR/ARHP Annual Meeting 2017
Mitochondrial ROS Activate the p38-MAPK/AP1 Pathway to Induce the Expression of Matrix Metalloproteases and IL-6 in Human Chondrocytes
Mohammad Y. Ansari¹ and Tariq M Haqqi², ¹Anatomy & Neurobiology, Northeast Ohio Medical University, Roostown, OH, ²Anatomy & Neurobiology, Northeast Ohio Medical University, Rootstown, OH
Background/Purpose: Mitochondria not only ‘power’ the cell, but are also essential for maintaining physiological levels of prooxidants (ROS) which is critical for homeostasis. Damaged and…
Abstract Number: 1013 • ACR/ARHP Annual Meeting 2014
Mitochondrial Function Is Impaired in Human Knee Osteoarthritic (OA) Chondrocytes and Improved By Pharmacologic AMPK Activation Via SIRT1 and PGC-1α
Ru Bryan¹, Yun Wang², Xianling Zhao³, Martin Lotz⁴ and Robert Terkeltaub⁵, ¹Medicine-Rheumatology, VA Medical Center/University of California San Diego, San Diego, CA, ²Medicine-Rheumatology, VA Medical Ctr/UCSD, San Diego, CA, ³VAMC, San Diego, CA, ⁴Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA, ⁵Medicine-Rheumatology, VA Medical Ctr/University of California San Diego, San Diego, CA
Background/Purpose Chondrocyte mitochondrial abnormalities have been identified in OA, and have the potential to mediate disease progression by promoting oxidative stress and inflammation-driven cartilage matrix…