Abstracts tagged "chemokines"

Abstract Number: 72 • 2016 ACR/ARHP Annual Meeting
Longitudinal Expression of CXCL10 in Psoriasis Patients That Develop Psoriatic Arthritis
Fatima Abji¹, Remy Pollock², Kun Liang³, Vinod Chandran⁴ and Dafna D Gladman⁵, ¹Rheumatology, University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, ²University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, ³Department of Statistics and Actuarial Science, University of Waterloo, Waterloo, ON, Canada, ⁴Rheumatology, University of Toronto, Toronto, ON, Canada, ⁵University of Toronto, Toronto, ON, Canada
Longitudinal Expression of CXCL10 in Psoriasis Patients that Develop Psoriatic Arthritis Patients Fatima Abji1, Remy Pollock1 Kun Liang2, Vinod Chandran1,3, Dafna D. Gladman1,3 1University of…
Abstract Number: 272 • 2016 ACR/ARHP Annual Meeting
Interferon Chemokine Score and Other Cytokine Measures Predict Changes in Disease Activity in Patients with Juvenile and Adult Dermatomyositis
Cynthia S. Crowson¹, Jeannette M. Olazagasti Lourido², Molly S. Hein³, Richard S. Pendegraft⁴, Michael A. Strausbauch⁵, Timothy B. Niewold⁶, Floranne C. Ernste⁷, Theresa L. Wampler Muskardin³, Erik J. Peterson⁸, Emily C. Gillespie⁹ and Ann M Reed¹⁰, ¹Health Sciences Research, Mayo Clinic, Rochester, MN, ²University of Puerto Rico, San Juan, Puerto Rico, ³Rheumatology, Mayo Clinic, Rochester, MN, ⁴Biomedical Statistics and informatics, Rochester, MN, ⁵Surgical Research, Mayo Clinic, Rochester, MN, ⁶Rheumatology and Immunology, Mayo Clinic, Rochester, MN, ⁷Division of Rheumatology, Mayo Clinic Rochester, Rochester, MN, ⁸Center for Immunology/Department of Medicine, University of Minnesota, Minneapolis, MN, ⁹Medicine, University of Minnesota, Minneapolis, MN, ¹⁰Rheumatology, Duke University, Durham, NC
Background/Purpose: Methods: Multiplexed immunoassays (Meso Scale Discovery) enabled simultaneous measurement of IFN-regulated chemokines and other pro- and anti-inflammatory cytokines specific to differentiation of specific…
Abstract Number: 829 • 2016 ACR/ARHP Annual Meeting
High Level of Chemokine CCL2 Is Associated with Lung Fibrosis Progression and Reduced Survival in Two Independent Systemic Sclerosis Cohorts
Anna Hoffmann-Vold¹, Richard Huyen², Elizabeth R. Volkmann², Oyvind Midtvedt¹, Vyacheslav Palchevskiy², May Brit Lund³, Torhild Garen¹, Trond Mogens Aalokken⁴, Anders Heiervang Tennøe¹, Stephen Samuel Weigt², Mike Shino², Rajan Saggar⁵, David Ross², Joseph Lynch III², Thor Ueland⁶, Michael Fishbein⁷, Pål Aukrust⁸, Øyvind Molberg¹ and John A Belperio², ¹Rheumatology, Oslo University Hospital, Oslo, Norway, ²University of California, Los Angeles, David Geffen School of Medicine, Los Angeles, CA, ³Respiratory Medicine, Oslo University Hospital, Oslo, Norway, ⁴Radiology, Oslo University Hospital, Oslo, Norway, ⁵Medicine, University of California, Los Angeles, David Geffen School of Medicine, Los Angeles, CA, ⁶Research, Oslo University Hospital, Oslo, Norway, ⁷Pathology and Laboratory Medicine, University of California, Los Angeles, Los Angeles, CA, ⁸Research Intitute for Internal Medicine, Oslo University Hospital, Rikshospitalet, Oslo, Norway
Background/Purpose: Markers for early identification of progressive interstitial lung disease (ILD) in systemic sclerosis (SSc) are in demand. The proto-typical inflammatory chemokine CCL2 has been linked…
Abstract Number: 1120 • 2016 ACR/ARHP Annual Meeting
Interleukin-1β Stabilize CXCL2 mRNA and Increase Its Expression
Satoshi Yamasaki, Yusuke Yoshida and Eiji Sugiyama, Department of Clinical Immunology and Rheumatology, Hiroshima University Hospital, Hiroshima, Japan
Background/Purpose: Changes in gene expression are closely related to inflammation and joint destruction in RA. Recently, it has been recognized that post-transcriptional regulation of the…
Abstract Number: 1128 • 2016 ACR/ARHP Annual Meeting
Anti-Fractalkine Monoclonal Antibody Inhibits Cartilage Destruction and Bone Erosion in Collagen-Induced Arthritis Model
Kana Hoshino¹, Masayoshi Ohkuro², Wataru Ikeda¹, Tomoya Nakatani¹, Yoshikazu Kuboi³, Naoto Ishii¹, Toshihiko Yamauchi¹, Nobuyuki Yasuda¹ and Toshio Imai¹, ¹KAN Research Institute Inc., Chuo-ku, Kobe-shi, Japan, ²Research Project Promotion Group, EA Pharma Co., Ltd., Kawasaki-ku, Kawasaki-shi, Japan, ³Medicine Creation. Neuro Business Group, Eisai Co., Ltd., Tsukuba-shi, Japan
Background/Purpose: Rheumatoid arthritis (RA) is a chronic disease leading to joint destruction. In the previous Phase 1/2 clinical study, E6011, a novel humanized anti-fractalkine (FKN)…
Abstract Number: 1130 • 2016 ACR/ARHP Annual Meeting
Aminopeptidase N/CD13 Induces Monocyte Migration in Vitro and In Vivo and Signals through GPCR, Erk1/2, Jnk, Src, and NFκB
Yuxuan Du¹, W. Alexander Stinson², Phillip Campbell¹, Rachel Morgan¹, Nicholas Lepore¹, Ellen Cealey¹, Jonatan Hervoso¹, Huadong Cui², David Fox³ and M. Asif Amin⁴, ¹Rheumatology, Division of Rheumatology, University of Michigan Medical Center, Ann Arbor, MI, ²Division of Rheumatology, University of Michigan Medical Center, Ann Arbor, MI, ³Department of Medicine [Division of Rheumatology], University of Michigan, Ann Arbor, MI, ⁴Internal Medicine, Division of Rheumatology, University of Michigan Medical Center, Ann Arbor, MI
Background/Purpose: Aminopeptidase N/CD13 is a metalloproteinase expressed on the surface of fibroblast like synoviocytes (FLS). It is found in soluble form in serum and rheumatoid…
Abstract Number: 1318 • 2016 ACR/ARHP Annual Meeting
Profile of Macrophage-Derived Cytokines and Chemokines of Patients with Chikungunya-Induced Chronic Arthralgia/Arthritis
Idali Martinez¹, Edwin Lopez¹, Zelma L. Rios¹ and Luis M. Vilá², ¹Department of Microbiology, University of Puerto Rico Medical Sciences Campus, San Juan, Puerto Rico, ²Department of Medicine, Division of Rheumatology, University of Puerto Rico Medical Sciences Campus, San Juan, Puerto Rico
Background/Purpose: Chikungunya virus (CHIKV) caused a large epidemic in Puerto Rico in 2014 with more than 30,000 reported cases. Many of the affected individuals developed…
Abstract Number: 1458 • 2016 ACR/ARHP Annual Meeting
Intraadrenal Dendritic Cells Inhibit Corticosterone Response during Collagen-Induced Arthritis – a Role for IL-1β and CXC Chemokines?
Hubert Stangl, Christine Wolff, Martin Lesiak and Rainer Straub, Laboratory of Exp. Rheumatology and Neuroendocrino-Immunology, University Hospital Regensburg, Regensburg, Germany
Background/Purpose: In rheumatoid arthritis (RA) and collagen-induced arthritis (CIA) the phenomenon of a relative insufficiency of adrenal glands to produce an adequate amount of anti-inflammatory…
Abstract Number: 2151 • 2016 ACR/ARHP Annual Meeting
Fractalkine (CX3CL1) Is Expressed By Arterial Endothelium and Vascular Smooth Muscle Cells (VSMC) in GCA
Marc Corbera-Bellalta¹, Ester Planas-Rigol², Nekane Terrades-Garcia¹, Marco Antonio Alba¹, Georgina Espígol-Frigolé², Sergio Prieto-González², Jose Hernández-Rodríguez¹ and Maria C. Cid³, ¹Vasculitis Research Unit. Department of Autoimmune Diseases, Hospital Clínic. University of Barcelona. IDIBAPS, Barcelona, Spain, ²Department of Autoimmune and Systemic Diseases, Hospital Clínic. University of Barcelona. IDIBAPS, Barcelona, Spain, ³Autoimmune and Systemic Diseases, Hospital Clínic. University of Barcelona. IDIBAPS, Barcelona, Spain
Background/Purpose: The development of giant-cell arteritis (GCA) lesions requires amplification cascades resulting in continuous recruitment of lymphocytes and monocytes. Interferon-gamma (IFNg)- induced or up-regulated chemokines…
Abstract Number: 2153 • 2016 ACR/ARHP Annual Meeting
Syndecans Mediate Rantes/CCL5 Induced MMP-1 and MMP-13 Expression in Rheumatoid Arthritis Synovial Fibroblasts
Solomon Agere, Nahid Akhtar and Salahuddin Ahmed, Department of Pharmaceutical Sciences, Washington State University, College of Pharmacy, Spokane, WA
Background/Purpose: RANTES/CCL5 (RANTES) is a C-C chemokine that binds to its receptor (CCR5) and initiates inflammatory processes in rheumatoid arthritis (RA) by facilitating leukocyte…
Abstract Number: 2284 • 2016 ACR/ARHP Annual Meeting
Differential Effect of MSU-Crystal Induced Inflammation on Macrophage Polarization
Rashid Ahmed¹, Nicole Yang², Changqi Sun³ and Anthony M. Reginato³, ¹Rhode Island Hospital, The Warren Alpert School of Medicine at Brown University, Providence, RI, ²Division of Rheumatology, Immunology and Allergy, Brigham and Women’s Hospital, Boston, MA, USA., Boston, MA, ³Division of Rheumatology, Rhode Island Hosital/The Warren Alpert School of Medicine of Brown University, Providence, RI
Background/Purpose: Gouty arthritis is a common inflammatory joint disease that arises in response to the deposition of monosodium urate (MSU) crystals in soft joints, periarticular…
Abstract Number: 2432 • 2016 ACR/ARHP Annual Meeting
Immune Abnormalities Leading to Exaggerated Production of IFN-Gamma (IFNγ) and the Therapeutic Response to an Anti-IFNγ Antibody in a Patient with NRLC4 Mediated Disease
Claudia Bracaglia¹, Giusi Prencipe², Manuela Pardeo¹, Geneviève Lapeyre³, Emiliano Marasco², Antonella Insalaco¹, Walter Ferlin³, Robert Nelson³, Cristina de Min³ and Fabrizio De Benedetti¹, ¹Division of Rheumatology, Ospedale Pediatrico Bambino Gesù IRCCS, Roma, Italy, Rome, Italy, ²Division of Rheumatology, Ospedale Pediatrico Bambino Gesù IRCCS, Rome, Italy, ³NovImmune S.A., Geneva, Switzerland
Background/Purpose: Animal and human data suggest that IFNγ plays a pathogenic role in HLH. A phase 2 trial with the anti-IFNγ monoclonal antibody NI-0501 in…
Abstract Number: 13L • 2015 ACR/ARHP Annual Meeting
Safety and Efficacy of E6011, an Anti-Fractalkine Monoclonal Antibody, in a First-in-Patient Phase 1/2 Study in Rheumatoid Arthritis
Yoshiya Tanaka¹, Tsutomu Takeuchi², Hisanori Umehara³, Toshihiro Nanki⁴, Hideto Akama⁵, Nobuyuki Yasuda⁵, Fumitoshi Tago⁵, Makoto Kawakubo⁵, Seiichiro Hojo⁵, Tetsu Kawano⁶ and Toshio Imai⁶, ¹The First Department of Internal Medicine, University of Occupational and Environmental Health, Japan, Kitakyushu, Japan, ²Dept. of Internal Medicine, School of Medicine Keio University, Tokyo, Japan, ³Kyoto University Graduate School of Medicine, Kyoto, Japan, ⁴School of Medicine, Faculty of Medicine, Toho University, Tokyo, Japan, ⁵EISAI Co. Ltd., Tokyo, Japan, ⁶KAN Research Institute, Inc., Kobe, Japan
Background/Purpose: Fractalkine (CX3CL1, designated as FKN hereafter) is the sole member of the CX3C-chemokine which leads to dual actions, chemotaxis and cell adhesion for leukocytes…
Abstract Number: 2086 • 2015 ACR/ARHP Annual Meeting
Inhibition of Macrophage Inflammatory Protein 1-Alpha (CCL3) Significantly Reduced Bone Resorption in Vitro and the Development of Erosive Joint Pathology in Collagen-Induced Arthritis
Lauren A. Jordan¹, Ruth Davies¹, Alastair J. D. Robertson², Ann K. Harvey¹, Ernest H. Choy¹, Malin Erlandsson³, Maria I. Bokarewa⁴, Rachel J. Errington¹ and Anwen S. Williams¹, ¹Cardiff University, Institute of Infection and Immunity, Tenovus Building, University Hospital of Wales, Cardiff, United Kingdom, ²William Harvey Hospital, Willesborough, Ashford, United Kingdom, ³University of Goteborg, Goteborg, Sweden, ⁴Guldhedsgatan 10, University of Goteborg, Goteborg, Sweden
Background/Purpose: The destruction of bone is a common feature of diseases like rheumatoid arthritis (RA) and multiple myeloma (MM). CCL3 is significantly elevated in the…
Abstract Number: 2834 • 2015 ACR/ARHP Annual Meeting
CXCL10 Expression Is Elevated in Synovial Fluid of Psoriatic Arthritis Patients
Anastasiya Muntyanu¹, Fatima Abji², Kun Liang³, Vinod Chandran⁴ and Dafna Gladman⁴, ¹Toronto Western Hospital, University of Toronto, Toronto, ON, Canada, ²Rheumatology, Toronto Western Hospital and University of Toronto, Toronto, ON, Canada, ³Department of Statistics and Actuarial Science, University of Waterloo, Waterloo, ON, Canada, ⁴Rheumatology, University of Toronto, Toronto Western Hospital, Toronto, ON, Canada
Background/Purpose: Psoriatic arthritis (PsA), an inflammatory musculoskeletal disease, develops in approximately 30% of patients with psoriasis. We previously identified C-X-C motif chemokine 10 (CXCL10) as…

« Previous Page
1
…
5
6
7
8
9
…
12
Next Page »

All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM CT on October 25. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

Violation of this policy may result in the abstract being withdrawn from the meeting and other measures deemed appropriate. Authors are responsible for notifying colleagues, institutions, communications firms, and all other stakeholders related to the development or promotion of the abstract about this policy. If you have questions about the ACR abstract embargo policy, please contact ACR abstracts staff at [email protected].