ACR Meeting Abstracts

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Abstracts tagged "chemokines"

  • Abstract Number: 0655 • ACR Convergence 2022

    Proteomic Analysis of Histological Lesions Lupus Nephritis Identifies an Inflammatory Signature of Fibrous Crescents

    Alessandra Ida Celia1, Jeffery Hodgin2, Avi Rosenberg3, Laurence S Magder4, Jill Buyon5, Betty Diamond6, Judith James7, William Apruzzese8, Paride Fenaroli9, Derek Fine1, Jose Monroy-Trujillo1, Mohamed G. Atta1, Peter izmirly10, Michael Belmont5, Anne Davidson6, Daniel W. Goldman11, the Accelerating Medicines Partnership (AMP) RA/SLE12, Michelle Petri11 and Andrea Fava1, 1Johns Hopkins University, Baltimore, MD, 2University of Michigan, Ann Arbor, MI, 3Johns Hopkins University, Ballwin, MO, 4University of Maryland, Department of Epidemiology and Public Health, Baltimore, MD, 5NYU Grossman School of Medicine, New York, NY, 6Feinstein Institutes for Medical Research, Manhasset, NY, 7Oklahoma Medical Research Foundation, Oklahoma City, OK, 8Brigham and Women's Hospital, Boston, MA, 9Università degli Studi di Parma, Parma, Emilia-Romagna, Italy, 10NYU Long Island School of Medicine, New York, NY, 11Johns Hopkins University School of Medicine, Division of Rheumatology, Baltimore, MD, 12Multiple Insitutions

    Background/Purpose: We employed urine proteomics to define the molecular signatures associated with the histological features quantified by the NIH activity and chronicity indices. Methods: Glomerular…
  • Abstract Number: 1165 • ACR Convergence 2022

    Pathogenicity of IL-17 Producing Cells in HLA-B27 Transgenic Rat Model of Spondyloarthritis

    Marie Beaufrère1, Manon Jacoutot1, Amel Ait Ali Said1, Roula Said-Nahal2, Gina Cosentino3, Chiara Rizzo3, Maxime Breban4 and Simon Glatigny4, 1Paris Saclay University / INSERM 1173, Montigny-le-Bretonneux, France, 2Rheumatology Division - Ambroise Pare Hospital, APHP, Boulogne-Billancourt, France, 3INSERM 1173, Montigny-le-Bretonneux, France, 41INSERM U1173, UFR Simone Veil, Versailles-Saint Quentin / Paris-Saclay University, Montigny-le-Bretonneux, France

    Background/Purpose: Spondylarthritis (SpA) is a group of chronic inflammatory disorders with osteoarticular and extraarticular symptoms, including colitis, highly associated with the human leukocyte antigen (HLA)…
  • Abstract Number: 1554 • ACR Convergence 2022

    Serum Biomarkers in Association with Clinical and Vascular Disease Activity in Takayasu’s Arteritis

    Cameron Rankin1, Peter Grayson2, Bates Gribbons3, Kaitlin Quinn4, Christopher Redmond5 and Wanxia Tsai1, 1NIAMS/NIH, Bethesda, MD, 2National Institutes of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), National Institutes of Health (NIH), Bethesda, MD, 3McGovern Medical School, Colleyville, TX, 4National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), National Institutes of Health (NIH), Washington, DC, 5National Institutes of Health, Rockville, MD

    Background/Purpose: 18FDG-PET imaging can be used to directly assess vascular inflammation; however, limited access to this technology has restricted widespread adoption of this modality in…
  • Abstract Number: 0501 • ACR Convergence 2021

    Immunogenicity of a Single Dose of Covid-19 Vaccination in Patients with Systemic Sclerosis with or Without Immunosupression

    Vishal Kakkar1, Rebecca Ross2, Ranjitha Karanth3, Sumit Lahiri4, Panji Mulipa1, Pamela Hughes5, Brendan Clarke5, Clive Carter5, Mark Lobb5, Sinisa Savic6 and Francesco Del Galdo1, 1University of Leeds, Leeds, United Kingdom, 2LIRMM University of Leeds, Leeds, United Kingdom, 3Leeds Institute of Rheumatic and Musculoskeletal Medicine, LTHT, Leeds, United Kingdom, 4Leeds Teaching Hospitals NHS Trust, Leeds, United Kingdom, 5Transplant and Cellular Immunology, Leeds, United Kingdom, 6Leeds Institute of Rheumatic and Musculoskeletal Medicine, Leeds, United Kingdom

    Background/Purpose: Systemic Sclerosis (SSc) is a rare connective tissue disease with multi-systemic involvement, which at times requires the use of immunosuppressive medication. None of the…
  • Abstract Number: 0514 • ACR Convergence 2021

    Extracellular Sulfatase-2 Mediates TNF-α Inflammatory Signaling in Human Rheumatoid Arthritis Synovial Fibroblasts

    Ruby Siegel1, Anil singh1, Judy Vinh1, H. Mark Kenney2, Edward Schwarz3, David Fox4, Sadik Khuder5 and Salah-uddin Ahmed1, 1Washington State University, Spokane, WA, 2University of Rochester Medical Center, Rochester, NY, 3University of Rochester, Rochester, NY, 4Division of Rheumatology, University of Michigan Medical School, Ann Arbor, MI, 5Department of Medicine and Public Health, University of Toledo,, Toledo, OH

    Background/Purpose: TNF-α drives RA synovial fibroblast (RASF)-mediated hyperplasia and joint tissue destruction. Extracellular sulfatase-2 (Sulf-2) influences receptor/ligand binding and subsequent signaling of chemokines, cytokines, and…
  • Abstract Number: 0515 • ACR Convergence 2021

    The Extracellular Sulfatase-2 Inhibitor OKN-007 Abrogates TNF-α-induced Inflammatory Mediators in Human Rheumatoid Arthritis Synovial Fibroblasts

    Ruby Siegel, Sang Han and Salah-uddin Ahmed, Washington State University, Spokane, WA

    Background/Purpose: Recent unpublished findings from our lab show that the extracellular enzyme sulfatase-2 (Sulf-2) facilitates pro-inflammatory TNF-α signaling which activates rheumatoid arthritis synovial fibroblasts (RASFs).…
  • Abstract Number: 1365 • ACR Convergence 2021

    Release of High-Mobility Group Box-1 After an Raynaud’s Attack Potentially Leads to Fibroblast Activation and Interferon-γ Induced Protein-10 Production in Systemic Sclerosis

    Isabella Atzeni1, Yehya Al-Adwi2, Berber Doornbos-van der Meer2, Amel Eman Abdulle2, Anniek Van Roon2, Alja J. Stel2, Harry Van Goor2, Andries Smit2, Johanna Westra2 and Douwe J Mulder2, 1University of Groningen, University Medical Centre Groningen, Groningen, Groningen, Netherlands, 2University of Groningen, University Medical Centre Groningen, Groningen, Netherlands

    Background/Purpose: Raynaud’s Phenomenon (RP) leading to repetitive ischaemia and reperfusion (IR) stress, is the first recognisable sign of systemic sclerosis (SSc). Although RP has been…
  • Abstract Number: 1381 • ACR Convergence 2021

    Chemokines CCL2 and CCL17 as Potential Serum Biomarkers for Interstitial Lung Disease in Systemic Sclerosis

    Imon Barua1, Håvard Fretheim2, Hilde Jenssen Bjørkekjær3, Henriette Didriksen4, Oyvind Midtvedt2, Trond Mogens AAløkken2, Torhild Garen5, Oyvind Molberg6, John Belperio7 and Anna-Maria Hoffmann-Vold1, 1Department of Rheumatology, Oslo University Hospital, Oslo, Norway, 2Oslo University Hospital, Oslo, Norway, 3Department of Rheumatology, Sørlandet sykehus HF, Kristiansand, Norway, 4Oslo University Hospital, Moss, Norway, 5Department of Rheumatology, Oslo University Hospital, Oslo, Nepal, 6Oslo University Hospital, Oslo, Nepal, 7University of California Los Angeles Interstitial Lung Disease Center, Los Angeles, CA

    Background/Purpose: Systemic sclerosis (SSc) carries high risk for progressive interstitial lung disease (ILD). Several anti-inflammatory therapies have been used to treat SSc-ILD and recently the…
  • Abstract Number: 1440 • ACR Convergence 2021

    Targeting Endogenous Mesenchymal Stromal Cell Response to Interferong in Sjӧgren’s Syndrome

    Sara McCoy, Ilya Gurevic, Maxwell Parker and Jacques Galipeau, University of Wisconsin, Madison, WI

    Background/Purpose: Sjӧgren’s syndrome (SS) is a systemic autoimmune disease that is associated with a lymphoma risk 14-fold that of the general population. Greater focal lymphocytic…
  • Abstract Number: 1767 • ACR Convergence 2021

    CXCL5 Dampens Inflammation in Murine Lupus by Orchestral Suppression of Effector Cell Proliferation and Leukocyte Extravasation

    Xiubo Fan1, Chin Teck Ng1, Dianyang Guo1, Frances Lim1, Annie Law2, Julian Thumboo1, William Hwang3 and Andrea Low1, 1Singapore General Hospital, Singapore, Singapore, 2Singhealth, Singapore, Singapore, 3National Cancer Centre Singapore, Singapore, Singapore

    Background/Purpose: Systemic lupus erythematosus (SLE) is a potentially fatal autoimmune disease characterized by dysregulation of both innate and adaptive immunity. Current therapeutic options are limited,…
  • Abstract Number: 1837 • ACR Convergence 2021

    KL-6, CXCL11 and CTGF Are Potential Biomarkers in Response to Treatment in CTD-ILD

    Yu-Hsiang Chiu1, Mareye Voortman1, Eveline Delemarre1, Stefan Nierkens1, Pim de Jong1, Firdaus Mohamed Hoesein1, Jan Grutters2, Jacob van Laar1 and Julia Spierings3, 1University Medical Centre Utrecht, Utrecht, Netherlands, 2St. Antonius Hospital, Nieuwegein, Netherlands, 3University Medical Center Utrecht, Utrecht, Netherlands

    Background/Purpose: Connective tissue disease related interstitial lung disease (CTD-ILD) is common and an important cause of morbidity and mortality. We aimed to identify biomarkers in…
  • Abstract Number: 0011 • ACR Convergence 2021

    Differential Inflammation-mediated Function of Prokineticin 2 in the Synovial Fibroblasts of Patients with Rheumatoid Arthritis Compared to Osteoarthritis

    Kentaro Noda, Bianca Dufner and Rainer Straub, Laboratory of Experimental Rheumatology and Neuroendocrine Immunology, Department of Internal Medicine I, University Hospital Regensburg, Regensburg, Germany

    Background/Purpose: Prokineticin 2 (PK2) is a secreted protein involved in several pathological and physiological processes, including the regulation of inflammation, sickness behaviors, and the circadian…
  • Abstract Number: 0050 • ACR Convergence 2021

    Integrative Analysis of mRNAs to Identify Sex Differences in Th-17 Mediated Inflammation in Ankylosing Spondylitis

    Maricela Haghiac1, Maya Breitman2, Ricky Chan3, Ahmad Khalil3 and Marina Magrey4, 1Metrohealth Medical center, Cleveland, OH, 2MetroHealth Medical Center,Case Western Reserve University School of Medicine, Cleveland, OH, 3Case Western Reserve University, Cleveland, OH, 4Case Western Reserve University, MetroHealth Medical Center, Cleveland, OH, USA, Richfield, OH

    Background/Purpose: Gender has been shown to impact disease expression in ankylosing spondylitis. Men with AS are more likely to develop radiographic joint damage, while women…
  • Abstract Number: 0285 • ACR Convergence 2020

    CXCL13 Neutralization Reduces Neuropsychiatric Manifestations in MRL/lpr Mice

    Michelle Huang1, Ariel Stock1 and Chaim Putterman1, 1Albert Einstein College of Medicine, Bronx, NY

    Background/Purpose: Targeted treatments for neuropsychiatric systemic lupus erythematosus (NPSLE) remain challenging to develop due to the unclear pathogenesis of the disease. Our laboratory has previously…
  • Abstract Number: 0386 • ACR Convergence 2020

    Phase 1 Clinical Study of MGTA-145 in Combination with Plerixafor Shows Rapid Single-Day Mobilization and Collection of CD34+ Hematopoietic Stem Cells Without G-CSF

    John DiPersio1, Jonathan Hoggatt2, Steven Devine3, David Scadden2, Haley Howell4, Veit Schmelmer4, Glen Raffel4, Pat Falahee4, Kevin Goncalves4, William Savage4 and John Davis4, 1Washington University, Saint Louis, 2Massachusetts General Hospital, Boston, 3National Marrow Donor Program, Minneapolis, 4Magenta Therapeutics, Cambridge

    Background/Purpose: Autologous hematopoietic stem cell (HSC) transplantation is a recommended therapeutic option for selected patients with scleroderma and other autoimmune diseases. HSC transplant requires collection…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM ET on November 14, 2024. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

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