Abstracts tagged "chemokines"

Abstract Number: 737 • 2012 ACR/ARHP Annual Meeting
Citrullination of ENA-78/CXCL5 Results in Conversion From a Non-Monocyte Recruiting to a Monocyte Recruiting Chemokine
Ken Yoshida¹, Olex Korchynskyi², Paul P. Tak³, Takeo Isozaki⁴, Jeffrey H. Ruth⁵, Phillip Campbell⁶, Dominique L. Baeten⁷, Danielle M. Gerlag⁷, M. Asif Amin⁸ and Alisa E. Koch⁹, ¹Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, ²Department of Cellular Proliferation and Apoptosis, Institute of Cell Biology, Lviv, Ukraine, ³Departments of Experimental Immunology and Internal Medicine, GlaxoSmithKline U.K. and Academic Medical Center/University of Amsterdam, Amsterdam, Netherlands, ⁴Division of Rheumatology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI, ⁵Internal Medicine, Division of Rheumatology, University of Michigan Medical Center, Ann Arbor, MI, ⁶Department of Internal Medicine, University of Michigan, Ann Arbor, MI, ⁷Division of Clinical Immunology and Rheumatology, Academic Medical Center/University of Amsterdam, Amsterdam, Netherlands, ⁸Department of Medicine, University of Michigan, Ann Arbor, MI, ⁹Internal Medicine - Rheumatology, University of Michigan Medical School, Ann Arbor, MI
Background/Purpose: Citrullination is a post-translational modification that is the conversion of arginine to citrulline in proteins mediated by peptidylarginine deiminase (PAD). Antibodies directed towards the…

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