Abstracts tagged "chemokines"

Abstract Number: 1663 • 2012 ACR/ARHP Annual Meeting
G Protein Signaling Modulator 3 Is a Key Regulator of Monocyte-Driven Inflammatory Arthritis
Matthew J. Billard¹, Patrick M. Giguére², Brian Buckley², Marcus W. McGinnis¹, Roman Timoshchenko¹, Peng Liu¹, David P. Siderovski² and Teresa K. Tarrant³, ¹Thurston Arthritis Research Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, ²Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, NC, ³Medicine/Rheumatology, Thurston Arthritis Research Center, University of North Carolina at Chapel Hill, Chapel Hill, NC
Background/Purpose: Monocytes are critical to rheumatoid arthritis (RA) disease pathogenesis and are recruited to the inflamed synovium by inflammation-driven chemokines. G protein signaling modulator 3…
Abstract Number: 47 • 2012 ACR/ARHP Annual Meeting
Accumulation of CD34+ Hematopoietic Stem Cells in the Initial Inflammatory Human Fracture Hematoma Is Mediated Via Chemokine Receptor Type 3 Ligands
Paula Hoff¹, Timo Gaber¹, Martin Hahne¹, Cindy Strehl¹, Katharina Schmidt-Bleek², Gerd Burmester³, Gerhard Schmidmaier⁴, Georg Duda⁵, Carsten Perka⁶ and Frank Buttgereit⁷, ¹Department of Rheumatology and Clinical Immunology, Charité University Medicine, Berlin, Germany, ²Julius Wolff Institut, Charité University Medicine, Berlin, Germany, ³Department of Rheumatology and Clinical Immunology, Charité - Universitätsmedizin Berlin, Berlin, Germany, ⁴Department of Traumatology, Heidelberg University Hospital, Heidelberg, Germany, ⁵Julius Wolff Institute, Charité – Universitätsmedizin Berlin, Berlin, Germany, ⁶Center of Muscoloskeletal Surgery, Charité University Medicine, Berlin, Germany, ⁷Charité - Universitätsmedizin Berlin, Berlin, Germany
Background/Purpose: We have previously shown the early phase of human fracture healing to be characterized by hypoxia which promotes inflammation and chemoattraction. Hypoxia is also…
Abstract Number: 1674 • 2012 ACR/ARHP Annual Meeting
Myeloid Related Proteins Induce Muscle Derived Inflammatory Mediators in Juvenile Dermatomyositis
Kiran Nistala¹, Hemlata Varsani², Helmut Wittkowski³, Thomas Vogl⁴, Petra Krol⁵, Vanita Shah², Kamel Mamchaoui⁶, Paul Brogan², Johannes Roth⁷ and Lucy R. Wedderburn², ¹Paediatric Rheumatology International Trials Organization (PRINTO), Genova, Italy, ²Rheumatology Unit , Institute of Child Health, University College London (UCL), London, United Kingdom, ³Muenster, Germany, ⁴Institute of Immunology, University of Muenster, Muenster, Germany, ⁵Rheumatology Unit, Department of Paediatrics and Adolescent Medicine, Prague, Czech Republic, ⁶Institut de Myologie, Paris, France, ⁷Immunology, Institute of Immunology University of Muenster, Muenster, Germany
Background/Purpose: The etiopathogenesis of Juvenile Dermatomyositis (JDM) remains poorly understood. In particular the contribution of monocytes or macrophages, which are frequently observed to be an…
Abstract Number: 42 • 2012 ACR/ARHP Annual Meeting
Role of Stromal Cell-Derived Factor-1 Alpha Through Smad and MAPK Pathway On Endochondral Ossification
Gunwoo Kim¹, Seungwoo Han², Younkwan Jung³, Eunju Lee³, Hyeri Park³, Shirine E. Usmani⁴, Veronica Ulici⁴ and Frank Beier⁴, ¹Rheumatology, Fatima research institude, Daegu Fatima Hospital, Daegu, South Korea, ²Rheumatology, Fatima research institute, Daegu Fatima Hospital, Daegu, South Korea, ³Laboratory for arthritis and bone biology, Fatima research institute, Daegu Fatima Hospital, Daegu, South Korea, ⁴Physiology and Pharmacology, Schulich School of Medicine and Dentistry, London, ON, Canada
Background/Purpose: The main cellular events of articular chondrocytes during osteoarthritis are a loss of the traits as permanent cartilage, and a transition to hypertrophic chondrocytes…
Abstract Number: 1603 • 2012 ACR/ARHP Annual Meeting
Inhibitor of DNA Binding 1 As a Secreted Angiogenic Transcription Factor in Rheumatoid Arthritis
Takeo Isozaki¹, M. Asif Amin², Alisa E. Koch³, Ali Arbab⁴, Stephanie A. Shuman¹, Christine M. Ha¹, G. Kenneth Haines III⁵ and Jeffrey H. Ruth⁶, ¹Division of Rheumatology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI, ²Department of Medicine, University of Michigan, Ann Arbor, MI, ³Internal Medicine - Rheumatology, University of Michigan Medical School, Ann Arbor, MI, ⁴Diagnostic Radiology, Henry Ford Hospital and Medical Centers, Detroit, MI, ⁵Department of Pathology, Yale University, New Haven, CT, ⁶Internal Medicine, Division of Rheumatology, University of Michigan Medical Center, Ann Arbor, MI
Background/Purpose: Rheumatoid arthritis (RA) is characterized by enhanced blood vessel development in joint synovium. This involves the recruitment of endothelial progenitor cells (EPCs), allowing for…
Abstract Number: 1506 • 2012 ACR/ARHP Annual Meeting
Primary Human Scleroderma Dermal Endothelial Cells Exhibit Defective Angiogenesis
Pei-Suen Tsou¹, Bradley J. Rabquer², Beatrix Balogh², Ann Kendzicky², Bashar Kahaleh³, Elena Schiopu⁴, Dinesh Khanna⁵ and Alisa E. Koch⁶, ¹Internal Medicine, Division of Rheumatology, University of Michigan Medical Center, Ann Arbor, MI, ²University of Michigan Medical School, Ann Arbor, MI, ³Medicine/Rheumatology, University of Toledo, Toledo, OH, ⁴Rheumatology/Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, ⁵Division of Rheumatology, University of Michigan Medical Center, Ann Arbor, MI, ⁶Internal Medicine - Rheumatology, University of Michigan Medical School, Ann Arbor, MI
Background/Purpose: Angiogenesis, the formation of new blood vessels, plays a critical role in a number of pathological processes including systemic sclerosis (scleroderma, SSc). SSc is…
Abstract Number: 1474 • 2012 ACR/ARHP Annual Meeting
Interferon-Inducible Chemokines Correlate with Disease Severity in Systemic Sclerosis
Xiaochun Liu¹, Maureen D. Mayes¹, Filemon K. Tan¹, Minghua Wu¹, John D. Reveille², Brock E. Harper³, Hilda T. Draeger⁴, Emilio B. Gonzalez⁵ and Shervin Assassi⁶, ¹Rheumatology, University of Texas Health Science Center at Houston, Houston, TX, ²Internal Medicine/Rheumatology, Univ of Texas Health Science Center at Houston, Houston, TX, ³Int Med/Rheumatology, University of Texas Medical Branch, Galveston, TX, ⁴Med/Clinical/Immunology, Univ of TX Health Sci Ctr, San Antonio, TX, ⁵Rheumatolgoy/Dept Int Med, University of Texas Medical Branch, Galveston, TX, ⁶Rheumatology, Univ of Texas Health Science Houston, Houston, TX
Plasma Interferon Inducible Chemokine Score: Stable Marker of Disease Severity in Systemic SclerosisABSTRACT:Background/Purpose: The most prominent gene expression profile in the peripheral blood of patients…
Abstract Number: 1101 • 2012 ACR/ARHP Annual Meeting
Condroitin Sulfate Decreases Chemokine Levels and Synovitis in knee osteoarthritis Patients
Jordi Monfort¹, Paula Escudero², Cristobal Orellana³, Laura Piqueras⁴, Laura Tio⁵, Francisco Montañés⁶, Natalia García⁷, Chantal Company², Pere Benito⁸ and Maria Jesús Sanz², ¹Reumatologia, Hospital del Mar, Barcelona, Spain, ²Pharmacology, Universitary Clinic Hospital Research Foundation-INCLIVA, University of Valencia, Valencia, Spain, ³Rheumatology, Corporació Sanitaria Parc Taulí, Sabadell, Spain, ⁴University Clinic Hospital Research Foundation-INCLIVA, University of Valencia, Valencia, Spain, ⁵U.R. Inflamació cel·lular i cartílag, GRICIC. FIMIM, Barcelona, Spain, ⁶Rhaumatology, Hospital del Mar, Barcelona, Spain, ⁷GRICIC. FIMIM, Barcelona, Spain, ⁸Hospital del Mar, Barcelona, Spain
Background/Purpose: Synovitis is one of the major signs of structure damage in osteoarthritis (OA) progression. Chondroitin sulfate (CS) is an effective drug in the treatment…
Abstract Number: 1064 • 2012 ACR/ARHP Annual Meeting
CD1c-Expressing Myeloid Dendritic Cells From Joints of Rheumatoid Arthritis Patients Produce Increased Levels of T Cell-Attracting Chemokines and Strongly Activate Autologous T Cells
F.M. Moret¹, C.E. Hack², F.P.J.G. Lafeber¹, T.R.D.J. Radstake¹ and J.A.G. van Roon¹, ¹Rheumatology & Clinical Immunology, University Medical Center Utrecht, Utrecht, Netherlands, ²Immunology, UMC Utrecht, Utrecht, Netherlands
Background/Purpose: Myeloid dendritic cells (mDCs) are potent T cell-activating antigen-presenting cells that have been implicated to play a crucial role in the regulation of tolerance…
Abstract Number: 899 • 2012 ACR/ARHP Annual Meeting
A Role for Soluble Interleukin-6 Receptor As an Antagonist of Interleukin-27 Signaling
Misato Hashizume¹, Keiko Esaki² and Yoshihiro Matsumoto¹, ¹Product Research Department, Chugai Pharmaceutical Co., Ltd., Gotemba, Japan, ²Discovery Research Department, Chugai Pharmaceutical Co., Ltd., Gotemba, Japan
Background/Purpose: Recently, it has been reported that interleukin (IL)-27 treatment reduces inflammation and ameliorates arthritis in collagen-induced arthritis mice. IL-27 is a heterodimeric cytokine composed…
Abstract Number: 879 • 2012 ACR/ARHP Annual Meeting
Fucosyltransferase 1 (fut1) Is Overexpressed in Rheumatoid Arthritis Synovial Tissue and Modifies Cytokine Production
Takeo Isozaki¹, Jeffrey H. Ruth², M. Asif Amin¹, Phillip L. Campbell¹, Steven E. Domino³, G. Kenneth Haines III⁴ and Alisa E. Koch⁵, ¹Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, ²Internal Medicine, Division of Rheumatology, University of Michigan Medical Center, Ann Arbor, MI, ³Department of Obstetrics and Gynecology, University of Michigan, Ann Arbor, MI, ⁴Department of Pathology, Yale University, New Haven, CT, ⁵Internal Medicine - Rheumatology, University of Michigan Medical School, Ann Arbor, MI
Background/Purpose: Rheumatoid arthritis (RA) is a systemic autoimmune disease characterized by inflammation and joint destruction. Angiogenesis and cytokine production are involved in the pathogenesis of…

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