ACR Meeting Abstracts

ACR Meeting Abstracts

  • Meetings
    • ACR Convergence 2024
    • ACR Convergence 2023
    • 2023 ACR/ARP PRSYM
    • ACR Convergence 2022
    • ACR Convergence 2021
    • ACR Convergence 2020
    • 2020 ACR/ARP PRSYM
    • 2019 ACR/ARP Annual Meeting
    • 2018-2009 Meetings
    • Download Abstracts
  • Keyword Index
  • Advanced Search
  • Your Favorites
    • Favorites
    • Login
    • View and print all favorites
    • Clear all your favorites
  • ACR Meetings

Abstracts tagged "chemokines"

  • Abstract Number: 1064 • 2012 ACR/ARHP Annual Meeting

    CD1c-Expressing Myeloid Dendritic Cells From Joints of Rheumatoid Arthritis Patients Produce Increased Levels of T Cell-Attracting Chemokines and Strongly Activate Autologous T Cells

    F.M. Moret1, C.E. Hack2, F.P.J.G. Lafeber1, T.R.D.J. Radstake1 and J.A.G. van Roon1, 1Rheumatology & Clinical Immunology, University Medical Center Utrecht, Utrecht, Netherlands, 2Immunology, UMC Utrecht, Utrecht, Netherlands

    Background/Purpose: Myeloid dendritic cells (mDCs) are potent T cell-activating antigen-presenting cells that have been implicated to play a crucial role in the regulation of tolerance…
  • Abstract Number: 899 • 2012 ACR/ARHP Annual Meeting

    A Role for Soluble Interleukin-6 Receptor As an Antagonist of Interleukin-27 Signaling

    Misato Hashizume1, Keiko Esaki2 and Yoshihiro Matsumoto1, 1Product Research Department, Chugai Pharmaceutical Co., Ltd., Gotemba, Japan, 2Discovery Research Department, Chugai Pharmaceutical Co., Ltd., Gotemba, Japan

    Background/Purpose: Recently, it has been reported that interleukin (IL)-27 treatment reduces inflammation and ameliorates arthritis in collagen-induced arthritis mice. IL-27 is a heterodimeric cytokine composed…
  • Abstract Number: 879 • 2012 ACR/ARHP Annual Meeting

    Fucosyltransferase 1 (fut1) Is Overexpressed in Rheumatoid Arthritis Synovial Tissue and Modifies Cytokine Production

    Takeo Isozaki1, Jeffrey H. Ruth2, M. Asif Amin1, Phillip L. Campbell1, Steven E. Domino3, G. Kenneth Haines III4 and Alisa E. Koch5, 1Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, 2Internal Medicine, Division of Rheumatology, University of Michigan Medical Center, Ann Arbor, MI, 3Department of Obstetrics and Gynecology, University of Michigan, Ann Arbor, MI, 4Department of Pathology, Yale University, New Haven, CT, 5Internal Medicine - Rheumatology, University of Michigan Medical School, Ann Arbor, MI

    Background/Purpose: Rheumatoid arthritis (RA) is a systemic autoimmune disease characterized by inflammation and joint destruction. Angiogenesis and cytokine production are involved in the pathogenesis of…
  • Abstract Number: 2353 • 2012 ACR/ARHP Annual Meeting

    TLR2 Activation by Acute Serum Amyloid A Induces Pro-Inflammatory Mechanisms in a Novel Ex Vivo Temporal Artery Explant Culture/Model of Giant Cell Arteritis

    Peadar Rooney1, Danielle Molloy1, Jennifer McCormick2, Mary Connolly1, Sinead M. Miggin3, Ashwini Maratha3, Douglas J. Veale4, Conor Murphy5, Eamonn Molloy6 and Ursula Fearon7, 1Rheumatology, Dublin Academic Medical Centre, Dublin, Ireland, 2Dublin Academic Medical Centre, Translational Rheumatology Research Group, Dublin, Ireland, 3Biology, Immune Signalling Laboratory, Maynooth, Ireland, 4Rheumatology, St. Vincent's University Hospital, Dublin 4, Ireland, 5Department of Ophthalmology, Royal Victoria Eye and Ear Hospital, Dublin, Ireland, 6Rheumatology, Dublin Academic Medical Centre, St. Vincent's University Hospital, Dublin, Ireland, 7Rheumatology, Translation Research Group, Dublin Academic Medical Centre, St. Vincent's University Hospital, Dublin, Ireland

    Background/Purpose: Giant cell arteritis (GCA) is the most common form of primary vasculitis. The pathogenesis of this disease is characterised by disregulated angiogenesis and inflammatory…
  • Abstract Number: 881 • 2012 ACR/ARHP Annual Meeting

    Microrna-155 Regulates Chemokines and Chemokine Receptors in Rheumatoid Arthritis Monocyte

    Aziza Elmesmari1, Derek S. Gilchrist1, Alasdair R. Fraser1, Diane Vaughan1, Ross McQueenie2, Gerard J. Graham1, James Brewer3, Iain B. McInnes1 and Mariola Kurowska-Stolarska1, 1Immunology, Institute of Infection,Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom, 2Infection, Immunity and Inflammation, University of Glasgow, Glasgow, United Kingdom, 3Immunology, Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom

    Background/Purpose:   Rheumatoid arthritis (RA) is characterized by synovial tissue inflammation leading to joint destruction. Monocytes/macrophages are major effector cells in RA synovitis, principally by releasing…
  • Abstract Number: 2338 • 2012 ACR/ARHP Annual Meeting

    1,25(OH)2D3 Modulates the Migration Pattern of Th17 Cells From Patients with Rheumatoid Arthritis

    Wendy Dankers1, Jan Piet van Hamburg2, Patrick S. Asmawidjaja1, Nadine Davelaar1, Hoyan Wen3, Anne-Marie Mus1, Edgar Colin2, Johannes van Leeuwen4, Johanna M.W. Hazes5 and Erik Lubberts1, 1Rheumatology, Erasmus MC, University Medical Center, Rotterdam, Netherlands, 2Rheumatology, Erasmus MC, Rotterdam, Netherlands, 3Rheumatology and Immunology, Erasmus MC, University Medical Center, Rotterdam, Netherlands, 4Internal Medicine, Erasmus MC, University Medical Center, Rotterdam, Netherlands, 5Rheumatology, Erasmus University Medical Center, Rotterdam, Netherlands

    Background/Purpose: Vitamin D has suppressive effects on autoimmune diseases, such as rheumatoid arthritis (RA). Within these diseases, T-helper-17 (Th17) cells have been implicated to play…
  • Abstract Number: 883 • 2012 ACR/ARHP Annual Meeting

    Role of Phospholipase D1 (PLD1) in the Expression of Proinflammatory Genes in Rheumatoid Arthritis Synovial Fibroblasts (RASF)

    Sean C. Friday1 and David A. Fox2, 1Rheumatology, The University of Michigan, Ann Arbor, MI, 2Rheumatology/Int Medicine, Univ of Michigan Med Ctr, Ann Arbor, MI

    Background/Purpose: Interleukin-17 (IL-17) and Tumor Necrosis Factor alpha (TNFa), when co-applied to RASF, induce synergistic expression of proinflammatory genes such as IL-6 and IL-8.  Work…
  • Abstract Number: 2288 • 2012 ACR/ARHP Annual Meeting

    The Role of TCR Vä1+ NKT Cells in Systemic Sclerosis Patients with Interstitial Pneumonitis

    Seiji Segawa1, Daisuke Goto2, Masanobu Horikoshi2, Shinya Hagiwara2, Naoto Umeda2, Hiroshi Ogishima2, Yuya Kondo1, Hiroto Tsuboi1, Makoto Sugihara1, Taichi Hayashi1, Yusuke Chino1, Isao Matsumoto1 and Takayuki Sumida1, 1Division of Rheumatology, Department of Internal Medicine, Faculty of Medicine, University of Tsukuba, Tsukuba City, Japan, 2Department of Internal Medicine, Faculty of Medicine, University of Tsukuba, Tsukuba City, Japan

    Background/Purpose: Interstitial pneumonia (IP) is one of the critical complications in patients with several autoimmune diseases. However, the exact mechanism of IP remains elusive. Recently,…
  • Abstract Number: 734 • 2012 ACR/ARHP Annual Meeting

    Chemokine (C-C Motif) Receptor 2 Signaling Mediates Persistent Pain in Experimental Osteoarthritis

    Rachel E. Miller1, Phuong Tran2, Rosalina Das2, Nayereh Ghoreishi-Haack2, Richard J. Miller3 and Anne-Marie Malfait4, 1Rheumatology/Biochemistry, Rush University Medical Center, Chicago, IL, 2Rheumatology, Rush University Medical Center, Chicago, IL, 3Molecular Biochemistry and Pharmacology, Northwestern University, Chicago, IL, 4Internal Medicine/Biochemistry, Rush University Medical Center, Chicago, IL

    Background/Purpose: To investigate the role of MCP-1/CCR2 in the development of pain in osteoarthritis (OA) using a mouse model, destabilization of the medial meniscus (DMM).…
  • Abstract Number: 2291 • 2012 ACR/ARHP Annual Meeting

    Enhanced Release of S100A9 and Hepatocyte Growth Factor by the Epidermis in Systemic Sclerosis

    Joanna Nikitorowicz Buniak1, Christopher P. Denton1, David J. Abraham2 and Richard J. Stratton1, 1Centre for Rheumatology and Connective Tissue Diseases, UCL Medical School, London, United Kingdom, 2UCL Medical School, London, United Kingdom

    Background/Purpose: Systemic sclerosis (SSc) is a severe disease of unknown aetiology characterised by cellular injury and activation in early stage, followed by autoimmunity and fibrosis.…
  • Abstract Number: 737 • 2012 ACR/ARHP Annual Meeting

    Citrullination of ENA-78/CXCL5 Results in Conversion From a Non-Monocyte Recruiting to a Monocyte Recruiting Chemokine

    Ken Yoshida1, Olex Korchynskyi2, Paul P. Tak3, Takeo Isozaki4, Jeffrey H. Ruth5, Phillip Campbell6, Dominique L. Baeten7, Danielle M. Gerlag7, M. Asif Amin8 and Alisa E. Koch9, 1Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, 2Department of Cellular Proliferation and Apoptosis, Institute of Cell Biology, Lviv, Ukraine, 3Departments of Experimental Immunology and Internal Medicine, GlaxoSmithKline U.K. and Academic Medical Center/University of Amsterdam, Amsterdam, Netherlands, 4Division of Rheumatology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI, 5Internal Medicine, Division of Rheumatology, University of Michigan Medical Center, Ann Arbor, MI, 6Department of Internal Medicine, University of Michigan, Ann Arbor, MI, 7Division of Clinical Immunology and Rheumatology, Academic Medical Center/University of Amsterdam, Amsterdam, Netherlands, 8Department of Medicine, University of Michigan, Ann Arbor, MI, 9Internal Medicine - Rheumatology, University of Michigan Medical School, Ann Arbor, MI

    Background/Purpose: Citrullination is a post-translational modification that is the conversion of arginine to citrulline in proteins mediated by peptidylarginine deiminase (PAD). Antibodies directed towards the…
  • « Previous Page
  • 1
  • …
  • 9
  • 10
  • 11
Advanced Search

Your Favorites

You can save and print a list of your favorite abstracts during your browser session by clicking the “Favorite” button at the bottom of any abstract. View your favorites »

All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM ET on November 14, 2024. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

Violation of this policy may result in the abstract being withdrawn from the meeting and other measures deemed appropriate. Authors are responsible for notifying colleagues, institutions, communications firms, and all other stakeholders related to the development or promotion of the abstract about this policy. If you have questions about the ACR abstract embargo policy, please contact ACR abstracts staff at [email protected].

Wiley

  • Online Journal
  • Privacy Policy
  • Permissions Policies
  • Cookie Preferences

© Copyright 2025 American College of Rheumatology