Abstracts tagged "chemokines and rheumatoid arthritis (RA)"

Abstract Number: 40 • 2017 ACR/ARHP Annual Meeting
B-Cell Attracting Chemokine-1 (BCA-1) and Macrophage Inflammatory Protein-3 Alpha (MIP-3α) Act Synergistically in the Recruitment of B Cells in the Rheumatoid Synovium
Estefanía Armas-González¹, María Jesús Domínguez-Luis², María Teresa Arce-Franco³, Javier Castro-Hernández³, Vanesa Hernandez⁴, Sagrario Bustabad⁵, Alberto Cantabrana-Alutiz⁶ and Federico Díaz-González⁷, ¹Universidad de La Laguna, Departamento de Medicina Física y Farmacología, Facultad de Medicina, La Laguna, Tenerife, Spain, ²Laboratorio de Reumatología. Hospital Universitario de Canarias, La Laguna, Spain, ³Laboratorio de Reumatología. Hospital Universitario de Canarias, La Laguna, Tenerife, Spain, ⁴Rheumatology, Servicio de Reumatología. Hospital Universitario de Canarias, S/C Tenerife, Spain, ⁵Rheumatology, Servicio de Reumatología. Hospital Universitario de Canarias, La Laguna, Tenerife, Spain, ⁶Servicio de Reumatología. Hospital Universitario Nuestra Señora de Candelaria, La Laguna, Tenerife, Spain, ⁷Servicio de Reumatología. Hospital Universitario de Canarias, Santa Cruz de Tenerife, Spain
Background/Purpose: B cells are recognized as key players in the pathogenesis of rheumatoid arthritis (AR) through the production of autoantibodies, the local production of proinflammatory…
Abstract Number: 1414 • 2017 ACR/ARHP Annual Meeting
Stimulation with Resistin Upregulates Chemokine Production By Fibroblast-like Synoviocytes from Patients with Rheumtoid Arthritis
Hiroshi Sato¹, Sei Muraoka¹, Natsuko Kusunoki¹, Shotaro Masuoka¹, Soichi Yamada¹, Toshio Imai², Shinichi Kawai³ and Toshihiro Nanki¹, ¹Division of Rheumatology, Department of Internal Medicine, Toho University School of Medicine, Tokyo, Japan, ²KAN Research Institute, Inc., Kobe, Japan, ³Department of Inflammation and Pain Control Research, Toho University School of Medicine, Tokyo, Japan
Background/Purpose: Adipose tissue synthesizes and releases physiologically active molecules that are known as adipokines. Resistin, an adipokine, has been widely studied the regulation of glucose…
Abstract Number: 16 • 2015 ACR/ARHP Annual Meeting
Rantes/CCL5 Selectively Induces MMP-1 and MMP-13 Production in Rheumatoid Arthritis Synovial Fibroblasts Via PKC-Î´ and JNK Pathways
Solomon A. Agere, Nahid Akhtar and Salahuddin Ahmed, Department of Pharmaceutical Sciences, Washington State University College of Pharmacy, Spokane, WA
Background/Purpose: RANTES/CCL5 (RANTES) is a C-C chemokine that binds to its receptor (CCR5) and initiates inflammatory processes in rheumatoid arthritis (RA) by facilitating leukocyte infiltration.…
Abstract Number: 1395 • 2013 ACR/ARHP Annual Meeting
CXCL13 Is Elevated In Early and In Established Seropositive Rheumatoid Arthritis and Correlates With Rheumatoid Factor Levels
Jonathan D. Jones¹, B. JoNell Hamilton², Greg Challener³, Artur Fernandes⁴, Pierre Cossette⁵, Patrick Liang⁴, Ariel Masetto⁶, HA Menard⁷, Nathalie Carrier⁸, Gilles Boire⁴ and William Rigby⁹, ¹Rheumatology, Geisel School of Medicine at Dartmouth College, Lebanon, NH, ²Microbiology and Immunology, Geisel School of Medicine at Dartmouth College, Lebanon, NH, ³Rheumatology, Geisel School of Medicine at Dartmouth, Lebanon, NH, ⁴Rheumatology Division, Centre Hospitalier Universitaire de Sherbrooke, Université de Sherbrooke, Sherbrooke, QC, Canada, ⁵Internal Medicine Departement, Centre Hospitalier Universitaire de Sherbrooke, Université de Sherbrooke, Sherbrooke, QC, Canada, ⁶Rheumatology, Centre Hospitalier Universitaire de Sherbrooke, Université de Sherbrooke, Sherbrooke, QC, Canada, ⁷Rheumatology, McGill University, Montréal, QC, Canada, ⁸Centre Hospitalier Universitaire de Sherbrooke, Université de Sherbrooke, Sherbrooke, QC, Canada, ⁹Department of Medicine, Geisel School of Medicine at Dartmouth, Lebanon, NH
Background/Purpose: CXCL13 is a B cell chemokine whose expression has been reported to be elevated in serum and synovium from patients with rheumatoid arthritis (RA). …
Abstract Number: 942 • 2013 ACR/ARHP Annual Meeting
CXCL13 Is a Marker Of Joint Involvement In Early Rheumatoid Arthritis
Stinne Greisen¹, Tue Rasmussen¹, Karen Schelde¹, Kristian Stengaard-Pedersen², Merete Lund Hetland³, Kim Hørslev-Petersen⁴, Bent Deleuran⁵ and Malene Hvid⁶, ¹Dept of Biomedicine, Aarhus University, Aarhus, Denmark, ²Arhus University Hospital, Aarhus, Denmark, ³Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, The Danish Rheumatologic Database (DANBIO), Glostrup Hospital., Copenhagen, Denmark, ⁴Institute of Regional Health Services Research, University of Southern Denmark, Graasten, Denmark, ⁵Department of Rheumatology, Aarhus University Hospital, Aarhus, Denmark, ⁶Dept. of Clinical Medicine, Aarhus University, Aarhus, Denmark
Background/Purpose: CXCL13 is central in the formation of lymphoid follicles in secondary and tertiary lymphoid tissue. It attracts CXCR5-expressing B cells and follicular helper T…

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