Abstracts tagged "chemokines and Cell Migration"

Abstract Number: 10 • 2019 ACR/ARP Annual Meeting
Roles of Histone Acetyltransferases CBP/p300 and Transcriptional Factor RORα/REV-ERBα Against TNFα-induced CCL2 Expression in RA-FLSs
Ikumi Okumura¹, Kohsuke Yoshida ¹, Kenta Kaneshiro ², Koto Uchida ³, Arisa Yaekura ⁴, Yuto Oketani ⁵, Kanta Morii ¹, Koji Tateishi ⁶, Yasuhiro Terashima ⁶, Yoshiko Kawasaki ⁷, Nao Shibanuma ⁷, Yoshitada Sakai ⁸ and Akira Hashiramoto ¹, ¹Kobe University Graduate School of Health Sciences, Kobe, Hyogo, Japan, ²Kobe University Graduate School of Health Sciences, Osaka, Osaka, Japan, ³Kobe University Graduate School of Health Sciences, Okayama, Okayama, Japan, ⁴Kobe University Graduate School of Health Sciences, Kawanishi, Hyogo, Japan, ⁵Kobe University Graduate School of Health Sciences, Himeji, Hyogo, Japan, ⁶Kohnan Kakogawa Hospital, Kakogawa, Hyogo, Japan, ⁷Kobe Kaisei Hospital, Kobe, Hyogo, Japan, ⁸Kobe University Graduate School of Medicine, Kobe, Hyogo, Japan
Background/Purpose: We have reported that TNFα induced expressions of clock gene Bmal1 by up-regulating transcriptional activator RORα and down-regulating repressor REV-ERBα in RA fibroblast-like synoviocytes…

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