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Abstracts tagged "certolizumab pegol"

  • Abstract Number: 561 • 2015 ACR/ARHP Annual Meeting

    Improvement in Disease Activity and the Long-Term Risk of Serious Infectious Events in Rheumatoid Arthritis Patients Treated with Certolizumab Pegol

    Jeffrey R. Curtis1, Marc de Longueville2, Cathy O'Brien2 and Boulos Haraoui3, 1University of Alabama at Birmingham, Birmingham, AL, 2UCB Pharma, Brussels, Belgium, 3Department of Medicine, Centre Hospitalier de l'Université de Montréal, Montréal, QC, Canada

    Background/Purpose: Anti-TNF drugs are an effective treatment option for rheumatoid arthritis (RA) patients (pts) but have been associated with an increased incidence of serious infectious…
  • Abstract Number: 654 • 2015 ACR/ARHP Annual Meeting

    Associations Between Skin Outcomes By Body Area Affected and Health-Related Quality of Life in Patients with Psoriatic Arthritis Treated with Certolizumab Pegol

    Alice B. Gottlieb1, Bengt Hoepken2, Luke Peterson3 and Peter C. Taylor4, 1Dermatology, Tufts Medical Center, Boston, MA, 2UCB Pharma, Monheim, Germany, 3UCB Pharma, Raleigh, NC, 4Nuffield Dept. of Orthopaedics, Rheumatology and Musculoskeletal, Sciences, Kennedy Institute of Rheumatology, University of Oxford,, Oxford, United Kingdom

    Background/Purpose: Patients (pts) with psoriatic arthritis (PsA) report poorer health-related quality of life (HRQoL) compared to the general population. As with psoriasis (PSO), it is…
  • Abstract Number: 1636 • 2015 ACR/ARHP Annual Meeting

    Clinical Benefit of 1-Year Certolizumab Pegol Treatment in MTX-Naïve, Early Rheumatoid Arthritis Patients Is Maintained after Discontinuation up to 1 Year

    Tatsuya Atsumi1, Kazuhiko Yamamoto2, Tsutomu Takeuchi3, Hisashi Yamanaka4, Naoki Ishiguro5, Yoshiya Tanaka6, Katsumi Eguchi7, Akira Watanabe8, Hideki Origasa9, Toshiharu Shoji10, Osamu Togo11, Toshiyuki Okada12, Désirée van der Heijde13, Nobuyuki Miyasaka14 and Takao Koike15, 1Division of Rheumatology, Endocrinology and Nephrology, Hokkaido University Graduate School of Medicine, Sapporo, Japan, 2Department of Allergy and Rheumatology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan, 3Keio University School of Medicine, Tokyo, Japan, 4Tokyo Women's Medical University, Tokyo, Japan, 5Department of Orthopedic Suregery, Nagoya University Hospital, Nagoya, Japan, 6The First Department of Internal Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan, 7Department of Immunology and Rheumatology, Nagasaki University, Nagasaki, Japan, 8Tohoku University, Sendai, Japan, 9Division of Biostatistics and Clinical Epidemiology, University of Toyama School of Medicine, Toyama, Toyama, Japan, 10Department of Clinical Research and Development, Otsuka Pharmaceutical Co., Ltd, Shinagawa-ku, Tokyo, Japan, 11Biometrics Group, UCB Pharma, Tokyo, Japan, 12Astellas Pharma Inc., Japan, Tokyo, Japan, 13University Hospital, Maastricht, Netherlands, 14Tokyo Medical and Dental University, Tokyo, Japan, 15Medicine II, Hokkaido University Graduate School of Medicine, Sapporo, Japan

    Background/Purpose: Efficacy and safety of certolizumab pegol (CZP) treatment in combination with optimized-dose MTX in Japanese MTX-naïve early rheumatoid arthritis (RA) patients (pts) with poor…
  • Abstract Number: 2523 • 2015 ACR/ARHP Annual Meeting

    Characteristics and Outcomes of Prospectively-Reported Pregnancies Exposed to Certolizumab Pegol from a Safety Database

    Megan E. B. Clowse1, Douglas C. Wolf2, Amanda Golembesky3, Laura Shaughnessy4, Dirk De Cuyper5 and Frauke Förger6, 1Rheumatology & Immunology, Duke University, Durham, NC, 2Atlanta Gastroenterology Associates, Atlanta, GA, 3UCB Pharma, Raleigh, NC, 48010 Arco Corporate Drive, Sui, UCB Pharma, Raleigh, NC, 5Safety Patient Solutions BioBrands, UCB Pharma, Brussels, Belgium, 6Rheumatology, Clinical Immunology and Allergology, Inselspital-University Hospital, Bern, Switzerland

    Background/Purpose: Data on the impact of anti-TNF medications on pregnancy outcomes are limited. Certolizumab pegol (CZP) is a PEGylated Fc-free anti-TNF approved in more than…
  • Abstract Number: 2736 • 2015 ACR/ARHP Annual Meeting

    Reduction of Disease Burden on Workplace and Household Productivity Following 52 Weeks of Treatment with Certolizumab Pegol in Combination with Methotrexate in DMARD-Naïve Patients with Active, Severe, Progressive Rheumatoid Arthritis

    VP Bykerk1, Clifton Bingham2, Gerd Burmester3, Daniel E. Furst4, Xavier Mariette5, Oana Purcaru6, Brenda VanLunen7, Michael Weinblatt8 and Paul Emery9, 1Hospital for Special Surgery, New York, NY, 2Johns Hopkins University, Baltimore, MD, 3Department of Rheumatology and Clinical Immunology, Charité - Universitätsmedizin Berlin, Berlin, Germany, 4Medicine, University of California, Los Angeles, David Geffen School of Medicine, Los Angeles, CA, 5Université Paris-Sud, AP-HP, Hôpitaux Universitaires Paris-Sud, Paris, France, 6Outcomes & Access Immunology, UCB, Brussels, Belgium, 7UCB Pharma, Raleigh, NC, 8Rheumatology Immunology & Allergy, Brigham and Women's Hospital, Boston, MA, 9Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, United Kingdom

    Background/Purpose: Rheumatoid arthritis (RA) is associated with work disability and lower employment rates (evidence shows 20–30% of pts are work disabled in the first 3…
  • Abstract Number: 2758 • 2015 ACR/ARHP Annual Meeting

    Clinical Utility and Factors Associated with Certolizumab Pegol Drug Levels and Anti-Drug Antibodies in the Long-Term Treatment of Rheumatoid Arthritis

    Meghna Jani1, Hector Chinoy1,2, John Isaacs3, Ann W. Morgan4, Anthony Wilson5, Kimme L. Hyrich6, Darren Plant1,2 and Anne Barton1,7, 1Centre for Musculoskeletal Research, University of Manchester, Manchester, United Kingdom, 2NIHR Manchester Musculoskeletal Biomedical Research Unit, Manchester Academy of Health Sciences, Manchester, United Kingdom, 3National Institute for Health Research Newcastle Biomedical Research Centre, Newcastle upon Tyne Hospitals NHS Foundation Trust and Newcastle University, Newcastle, United Kingdom, 4NIHR-Leeds Musculoskeletal Biomedical Research Unit, Leeds & Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, United Kingdom, 5Infection & Immunity, University of Sheffield, Sheffield, United Kingdom, 6Arthritis Research UK Centre for Epidemiology, The University of Manchester, Manchester, United Kingdom, 7NIHR Manchester Musculoskeletal Biomedical Research Unit, Central Manchester Foundation Trust and University of Manchester, Manchester Academy of Health Sciences, Manchester, United Kingdom

    Background/Purpose: Up to 40% of RA patients on anti-TNF agents fail to respond either due to primary or secondary inefficacy. One explanation is immunogenicity leading…
  • Abstract Number: 2835 • 2015 ACR/ARHP Annual Meeting

    Long-Term Improvements with Certolizumab Pegol in Joints and Extra-Articular Manifestations of Psoriatic Arthritis in Patients with and without Prior Anti-TNF Exposure

    Dafna D. Gladman1, Alice B. Gottlieb2, Bengt Hoepken3, Luke Peterson4 and Oliver FitzGerald5, 1Toronto Western Research Institute, Toronto, ON, Canada, 2Dermatology, Tufts Medical Center, Boston, MA, 3UCB Pharma, Monheim, Germany, 4UCB Pharma, Raleigh, NC, 5Department of Rheumatology, St. Vincent’s University Hospital, UCD School of Medicine and Medical Sciences and Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Dublin, Ireland

    Background/Purpose: Previous reports of RAPID-PsA (NCT01087788) have demonstrated the efficacy of certolizumab pegol (CZP) in patients (pts) with psoriatic arthritis (PsA) over 96 weeks (wks),1…
  • Abstract Number: 1251 • 2014 ACR/ARHP Annual Meeting

    Efficacy of Certolizumab in Patients with Refractory Uveitis to Other Biologic Therapy. Study of 7 Cases

    Montserrat Santos-Gómez1, Victor Llorens2, Marina Mesquida2, Ricardo Blanco1, Vanesa Calvo-Río1, Olga Maíz3, Ana Blanco4, Maite Sainz de la Maza2, Alfredo Adan2, Leyre Riancho-Zarrabeitia1 and Miguel A. González-Gay1, 1Rheumatology, Hospital Universitario Marqués de Valdecilla. IDIVAL. Santander. Spain, Santander, Spain, 2Ophthalmology, Hospital Clinic. Barcelona. Spain, Barcelona, Spain, 3Rheumatology, Hospital Universitario de Donostia. San Sebastián. Spain, San Sebastián, Spain, 4Ophthalmology, Hospital Universitario de Donostia. San Sebastián. Spain, San Sebastián, Spain

    Background/Purpose Anti-TNF-α therapy may be useful in cases of uveitis refractory to standard synthetic immunosuppressive drugs. Infliximab (IFX) and adalimumab (ADA) are the biologic agents…
  • Abstract Number: 1180 • 2014 ACR/ARHP Annual Meeting

    Dynamic Magnetic Resonance Imaging in the Assessment of the Response to Certolizumab Pegol in Rheumatoid Arthritis Patients: Results from a Phase IIIb Randomized Study

    Mikkel Østergaard1, Mette Bjørndal Axelsen2, Lennart T.H. Jacobsson3, Christopher Schaufelberger3, Michael Sejer Hansen4, Johannes W.J. Bijlsma5, Anna Dudek6, Maria Rell-Bakalarska7, Fabienne Staelens8, Robert Haake9, Britt Sundman-Engberg10 and Henning Bliddal11, 1Center for Rheumatology and Spine Diseases, Glostrup Hospital, Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Glostrup Hospital, Glostrup, Denmark, 2Center for Rheumatology and Spine Diseases, Glostrup Hospital, Copenhagen Center for Arthritis Research, Copenhagen University Hospital at Glostrup, Glostrup, Denmark, 3Department of Rheumatology and Inflammation Research, Institute of Medicine, The Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden, 4Department of Rheumatology, Gentofte Hospital, Copenhagen, Denmark, 5Department of Rheumatology and Clinical Immunology, University Medical Center Utrecht, Utrecht, Netherlands, 6Medica Pro Familia, Warsaw, Poland, 7Rheuma Medicus, Warsaw, Poland, 8UCB Pharma, Brussels, Belgium, 9UCB Pharma, Raleigh, NC, 10UCB Pharma, Stockholm, Sweden, 11The Parker Institute, Department of Rheumatology, Frederiksberg, Denmark

    Background/Purpose Magnetic resonance imaging (MRI) can detect early joint inflammation with high sensitivity, without use of radiation. The MARVELOUS study (NCT01235598), using the OMERACT RA…
  • Abstract Number: 566 • 2014 ACR/ARHP Annual Meeting

    Structural Progression of the Spine Measured By X-Ray in Patients with Axial Spondyloarthritis Treated with Certolizumab Pegol over 96 Weeks, Including Ankylosing Spondylitis and Non-Radiographic Axial Spondyloarthritis

    Désirée M. van der Heijde1, Walter P. Maksymowych2, Robert B. M. Landewé3, Christian Stach4, Owen Davies5, Tommi Nurminen4 and Jürgen Braun6, 1Department of Rheumatology, Leiden University Medical Center, Leiden, Netherlands, 2Department of Medicine, University of Alberta, Edmonton, AB, Canada, 3Department of Rheumatology, Amsterdam Rheumatology Center, Amsterdam, Netherlands, 4UCB Pharma, Monheim, Germany, 5UCB Pharma, Slough, United Kingdom, 6Rheumazentrum Ruhrgebiet, Ruhr-University Bochum, Herne, Germany

    Background/Purpose The impact of certolizumab pegol (CZP) on clinical and Magnetic Resonance Imaging outcomes in patients (pts) with axial spondyloarthritis (axSpA), including ankylosing spondylitis (AS)…
  • Abstract Number: 565 • 2014 ACR/ARHP Annual Meeting

    Effect of Certolizumab Pegol over 96 Weeks of Treatment on Inflammation of Spine and Sacroiliac Joints Measured By Magnetic Resonance Imaging in Patients with Axial Spondyloarthritis

    Jürgen Braun1, Walter P. Maksymowych2, Robert B. M. Landewé3, Christian Stach4, Owen Davies5, Tommi Nurminen4 and Desiree van der Heijde6, 1Rheumazentrum Ruhrgebiet, Ruhr-University Bochum, Herne, Germany, 2Department of Medicine, University of Alberta, Edmonton, AB, Canada, 3Department of Rheumatology, Amsterdam Rheumatology Center, Amsterdam, Netherlands, 4UCB Pharma, Monheim, Germany, 5UCB Pharma, Slough, United Kingdom, 6Department of Rheumatology, Leiden University Medical Center, Leiden, Netherlands

    Background/Purpose Previous results from RAPID-axSpA (NCT01087762) demonstrated that certolizumab pegol (CZP) reduced inflammation in the sacroiliac joints (SIJ) and spine, as assessed by Magnetic Resonance…
  • Abstract Number: 545 • 2014 ACR/ARHP Annual Meeting

    Long-Term Safety and Efficacy of Certolizumab Pegol over 96 Weeks in Patients with Psoriatic Arthritis with and without Prior Tumor Necrosis Factor Inhibitor Exposure

    Philip J. Mease1, Roy Fleischmann2, Jurgen Wollenhaupt3, Atul A. Deodhar4, Dafna D. Gladman5, Bengt Hoepken6, Luke Peterson7 and Désirée M. van der Heijde8, 1Division of Rheumatology Research, Swedish Medical Center and University of Washington, Seattle, WA, 2Rheumatology, University of Texas Southwestern Medical Center and Metroplex Clinical Research Center, Dallas, TX, 3Division of Reheumatology, Schoen-Klinik Hamburg-Eilbek Teaching Hospital of the University of Hamburg, Hamburg, Germany, 4Oregon Health and Sciences University, Portland, OR, 5University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, 6UCB Pharma, Monheim, Germany, 7Biostatistics US Group, UCB Pharma, Raleigh-Durham, NC, 8Department of Rheumatology, Leiden University Medical Center, Leiden, Netherlands

    Background/Purpose Previous reports of RAPID-PsA (NCT01087788) demonstrated efficacy and safety of certolizumab pegol (CZP) over 48 weeks (wks) in psoriatic arthritis (PsA) patients (pts), including…
  • Abstract Number: 474 • 2014 ACR/ARHP Annual Meeting

    Renacer Study: Assessment of 12-Month Efficacy and Safety of 168 Certolizumabpegol Rheumatoid Arthritis Treated Patients from a Multicenter Retrospective National Study in Spain

    Vicente Torrente-Segarra1, Ana Urruticoechea2, Héctor Corominas1, Amalia Sánchez3, Juan Víctor Tovar4, Alejandro Muñoz5, Anna Martínez6, José Antonio González4, Manuel Fernández7 and Noelia Vázquez on behalf of RENACER Study Group8, 1Hospital General Hospitalet-Sant Joan Despí Moisès Broggi, Hospitalet Llobregat, Barcelona, Spain, 2Hospital de Can Mises, Ibiza, Spain, 3Hospital Universitario Lucus Augusti, Lugo, Spain, 4Hospital General Universitario de Elche, Alicante, Spain, 5Hospital Universitario de Valme, Sevilla, Spain, 6Hospital La Ribera, Alzira, Valencia, Spain, 7Hospital Universitario de Guadalajara, Guadalajara, Spain, 8Hospital Universitario de Ceuta, Ceuta, Spain

    Background/Purpose: There's scant data of CertolizumabPEGol (CZP) in clinical practice. Study goal: assess efficacy and safety of CZP in RA patients at 3, 6,12-month (m), and…
  • Abstract Number: 102 • 2014 ACR/ARHP Annual Meeting

    Real-World Utilization, Patient Characteristics and Persistency of Certolizumab Pegol Vs Other Anti-TNFs for the Treatment of Rheumatoid Arthritis in the United Kingdom

    Frances Humby1, Stephen Kelly1, Angela V. Bedenbaugh2, Nawab Qizilbash3,4, Jochen Dunkel5, Belén SanJose3, Ignacio Mendez3, Jennifer Timoshanko6 and Jeyanesh Tambiah2, 1Centre for Experimental Medicine and Rheumatology, William Harvey Research Institute, Queen Mary University of London, London, United Kingdom, 2UCB Pharma, Smyrna, GA, 3OXON Epidemiology, London, United Kingdom, 4Epidemiology, London School of Hygiene & Tropical Medicine, London, United Kingdom, 5UCB Pharma, Monheim, Germany, 6UCB Pharma, Slough, United Kingdom

    Background/Purpose Several anti-TNFs are currently approved in Europe for RA treatment including certolizumab pegol (CZP), adalimumab (ADA), etanercept (ETN), golimumab and infliximab. UK NICE guidance…
  • Abstract Number: 1553 • 2014 ACR/ARHP Annual Meeting

    Disease Activity and Clinical Response Early in the Course of Treatment Predict Long-Term Outcomes in Psoriatic Arthritis Patients Treated with Certolizumab Pegol

    Philip J. Mease1, Roy Fleischmann2, Owen Davies3, Tommi Nurminen4 and Désirée van der Heijde5, 1Division of Rheumatology Research, Swedish Medical Center and University of Washington, Seattle, WA, 2Southwestern Medical Center, Department of Medicine, Metroplex Clinical Research Center, University of Texas, Dallas, TX, 3UCB Pharma, Slough, United Kingdom, 4UCB Pharma, Monheim, Germany, 5Department of Rheumatology, Leiden University Medical Center, Leiden, Netherlands

    Background/Purpose: Early non-response to biologic therapy has been shown to be associated with a low probability of long-term response in rheumatoid arthritis1 and psoriasis2. However,…
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