Abstracts tagged "central nervous system involvement"

Abstract Number: 2649 • 2014 ACR/ARHP Annual Meeting
“Point of Care” Neurocognitive Testing for Neuropsychiatric Systemic Lupus Erythematosis (NPSLE)
Debbie Rybak¹, Nicole Jordan¹, Noa Schwartz¹, Tamar Rubinstein², Bryan Freilich³, Irene Blanco⁴ and Chaim Putterman⁵, ¹Division of Rheumatology, Albert Einstein College of Medicine, Bronx, NY, ²Pediatric Rheumatology, Albert Einstein College of Medicine, Bronx, NY, ³Psychiatry, Albert Einstein College of Medicine, Bronx, NY, ⁴Rheumatology, Albert Einstein College of Medicine, Bronx, NY, ⁵The Division of Rheumatology, Albert Einstein College of Medicine, Bronx, NY
Background/Purpose There is currently no standardized tool to assess for NPSLE, and comprehensive neuropsychological testing can be lengthy and expensive. The Automated Neuropsychological Assessment Metric…
Abstract Number: 1658 • 2013 ACR/ARHP Annual Meeting
Vessel Wall Characteristics Using High Resolution Magnetic Resonance Imaging In Reversible Cerebral Vasoconstriction Syndrome and Central Nervous System vasculitis
Rula Hajj-Ali¹, Seby John², Tariq Hammad³, Emmanuel Obusez³, Ken Uchino², Stephen Jones⁴, Ferdinand Hui⁵, Russell Cerejo³ and Leonard H. Calabrese⁶, ¹Cleveland Clinic Foundation, Cleveland, OH, ²Neurology, Cleveland Clinic Foundation, Cleveland, OH, ³Cleveland Clinic, Cleveland, OH, ⁴Neuroradiology, Cleveland Clinic, Cleveland, OH, ⁵Cerebrovascular, Clevalnd Clinic, Cleveland, OH, ⁶Rheumatic & Immunologic Dis, Cleveland Clinic, Cleveland, OH
Background/Purpose: Distinguishing between reversible cerebral vasoconstriction syndrome (RCVS) and central nervous system (CNS) vasculitis is often a diagnostic dilemma. High-resolution-3-Tesla Magnetic Resonance Imaging with contrast…
Abstract Number: 1601 • 2013 ACR/ARHP Annual Meeting
The Presence Of IgG-Immune Complexes In The Cerebrospinal Fluids Is Associated With Central Neurocychiatric Manifestatin But Not With Intrathecal Production Of Proimmflammatory Cytokines/Chemokines Such as Interferon-α In Systemic Lupus Erythematosus
Taku Yoshio¹, Hiroshi Okamoto², Kazuhiro Kurasawa³, Yoshiaki Dei⁴, Shunsei Hirohata⁵ and Seiji Minota⁶, ¹Division of Rheumatology and Clinical Immunology, Jichi Medical University, School of Medicine, Shimotsuke-shi, Tochigi-ken, Japan, ²Minami-Otsuka Institute of Thechnology, Minami-Otsuka Clinic, Tokyo, Japan, ³Clinical Immunology, Dokkyo Medical University, Mibu-machi, Shimotsuga-gun, Tochigi-ken, Japan, ⁴Saiseikai Utsunomiya Hospital, Utsunomiya-shi, Tochigi-ken, Japan, ⁵Int Med/Rheumatol & Infec Dis, Kitasato University School of Medicine, Sagamihara, Japan, ⁶Division of Rheumatology and Clinical Immunology, Jichi Medical University, Shimotsuke,Tochigi, Japan
Background/Purpose: IgG-Immune complexes (IC) formed by CSF autoantibodies in patients with neuropsychiatric syndromes of systemic lupus erythematosus (NPSLE) has reported to stimulate the production of…
Abstract Number: 639 • 2013 ACR/ARHP Annual Meeting
Examination Of The Cytokine Profile Of The Cerebrospinal Fluid In Neuropsychiatric Systemic Lupus Erythematosus
Kunihiro Ichinose¹, Takeshi Ushigusa², Yoshikazu Nakashima³, Takahisa Suzuki³, Yoshiro Horai⁴, Shin-ya Kawashiri², Naoki Iwamoto², Mami Tamai³, Kazuhiko Arima⁴, Hideki Nakamura², Tomoki Origuchi⁵ and Atsushi Kawakami⁴, ¹Department of Immunology and Rheumatology, Unit of Translational Medicine, Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan, ²Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan, ³Unit of Translational Medicine, Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan, ⁴Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan, ⁵Department of Health Sciences, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
Examination of the cytokine profile of the cerebrospinal fluid in neuropsychiatric systemic lupus erythematosusBackground/Purpose: Neuropsychiatric systemic lupus erythematosus (NPSLE) is a serious complication in systemic…
Abstract Number: 2478 • 2012 ACR/ARHP Annual Meeting
Identification of Disease-Specific Neuroimaging Phenotypes in Childhood Inflammatory Brain Diseases
Tania Cellucci¹, Pascal N. Tyrrell², Shehla Sheikh³, Suzanne Laughlin⁴ and Susanne M. Benseler³, ¹Pediatrics/Rheumatology, The Hospital for Sick Children, Toronto, ON, Canada, ²Cardiology/Rheumatology, The Hospital for Sick Children, Toronto, ON, Canada, ³Rheumatology, The Hospital for Sick Children, Toronto, ON, Canada, ⁴Diagnostic Imaging, The Hospital for Sick Children, Toronto, ON, Canada
Background/Purpose: Magnetic resonance imaging (MRI) is a key diagnostic modality of childhood inflammatory brain diseases (IBrainD). While overlapping clinical features contribute to significant diagnostic uncertainty,…
Abstract Number: 1551 • 2012 ACR/ARHP Annual Meeting
Primary Angiitis of the Central Nervous System: Description of the First 52 Adult Patients Enrolled in the French COVAC’ Cohort
Hubert de Boysson¹, Mathieu Zuber², Olivier Naggara³, Jean-Philippe Neau⁴, Françoise Gray⁵, Marie-Germaine Bousser⁶, Isabelle Crassard⁶, Emmanuel Touze⁷, Pierre-Olivier Couraud⁸, Philippe Kerschen⁹, Catherine Oppenheim³, Olivier Detante¹⁰, Anthony Faivre¹¹, Nicolas Gaillard¹², Caroline Arquizan¹³, Boris Bienvenu¹⁴, Antoine Neel¹⁵, Loic Guillevin¹⁶, Christian Pagnoux¹⁷ and French Vasculitis Study Group and NeuroVascular Society¹⁸, ¹Division of Internal Medicine, Hôpital Cochin, University Paris Descartes, Paris, France, ²Department of Neurology, Groupe Hospitalier Saint-Joseph, Université Paris Descartes, Paris, France, ³Department of Neuroradiology, Hôpital Sainte-Anne, Paris, France, ⁴Department of Neurology, Centre Hospitalier Universitaire La Milétrie, Poitiers, France, ⁵Department of Pathology, APHP Hôpital Lariboisière, Université Paris Diderot, Paris, France, ⁶Department of Neurology, APHP Hôpital Lariboisière, Université Paris Diderot, Paris, France, ⁷Department of Neurology, Hôpital Sainte-Anne, Université Paris Descartes, Paris, France, ⁸Department of Cellular Biology, Institut Cochin, Paris, France, ⁹Department of Neurology, Centre Hospitalier Universitaire Henri Mondor, Créteil, France, ¹⁰Department of Neurology, Centre Hospitalier Universitaire de Grenoble, Grenoble, France, ¹¹Department of Neurology, Hôpital d'Instruction des Armées Saint-Anne, Toulon, France, ¹²Department of Neurology, Centre Hospitalier de Perpignan, Perpignan, France, ¹³Department of Neurology, Hôpital Gui de Chauliac, Université Montpellier, Montpellier, France, ¹⁴Division of Internal Medicine, Centre Hospitalier Régional Universitaire de Caen, Côte de Nacre, Caen, France, Caen, France, ¹⁵Department of Internal Medicine, Centre Hospitalier Universitaire de Nantes, Nantes, France, ¹⁶Internal Medicine, Division of Internal Medicine, Hôpital Cochin, University Paris Descartes, Paris, France, ¹⁷Rheumatology, Mount Sinai Hospital, Toronto, Canada, Toronto, ON, Canada, ¹⁸Paris, France
Background/Purpose: Primary angiitis of the central nervous system (PACNS) is rare and only 1 pediatric and 1 adult large cohorts including >30 PACNS patients have…
Abstract Number: 669 • 2012 ACR/ARHP Annual Meeting
Serum Anti N-Methyl-D-Aspartate Receptor Subunit 1 Antibodies Are Elevated in SLE
Ogawa Eisuke, Nagai Tatsuo, Arinuma Yoshiyuki and Hirohata Shunsei, Rheumatology and infectious diseases, Kitasato University School of Medicine, Kanagawa, Japan
Background/Purpose: Previous studies have demonstrated that the presence of autoantibodies against N-methyl-D-aspartate (NMDA) receptor subunit 2 (NR2) is closely associated with brain damages leading to…
Abstract Number: 304 • 2012 ACR/ARHP Annual Meeting
Burden of Childhood Central Nervous System Vasculitis: Identifying High Risk Factors for Poor Cognitive Outcome
Peter J. Gowdie¹, Marinka Twilt¹, Pascal N. Tyrrell¹, Robyn Westmacott², Tania Cellucci¹, Shehla Sheikh¹, Nick Blancette¹ and Susanne M. Benseler¹, ¹Rheumatology, The Hospital for Sick Children, Toronto, ON, Canada, ²Psychology, The Hospital for Sick Children, Toronto, ON, Canada
Background/Purpose: Childhood primary angiitis of the CNS (cPACNS) is an increasingly recognized, reversible cause of severe neurological and psychiatric deficit such as stroke, refractory seizures…
Abstract Number: 274 • 2012 ACR/ARHP Annual Meeting
Childhood Onset Angiitis of the Central Nervous System: What Outcomes Can We Expect?
Lena Das¹, Sook Fun Hoh², Terrence Thomas³ and Thaschawee Arkachaisri⁴, ¹Pediatric Rheumatology, KK Women's and Children's Hospital, Singapore, Singapore, ²Nursing, KK Women's and Children's Hospital, Singapore, Singapore, ³Pediatric Neurology, KK Women's and Children's Hospital, Singapore, Singapore, ⁴Rheumatology & Immunology, KK Women's and Children's Hospital and Duke-NUS Graduate Medical School, Singapore, Singapore
Background/Purpose: Imaging findings in large-medium vessel Childhood Onset Primary and Secondary Angiitis of the Central Nervous System (cPACNS & cSACNS) are well described, however, structural…
Abstract Number: 2684 • 2012 ACR/ARHP Annual Meeting
Cerebrospinal Fluid IL-6 and Anti-NMDA Receptor NR2 Antibodies As Surrogate Markers for CNS Disease Severity in SLE
Shunsei Hirohata, Yoshiyuki Arinuma and Eisuke Ogawa, Int Med/Rheumatol & Infec Dis, Kitasato University School of Medicine, Sagamihara, Japan
Background/Purpose: Neuropsychiatric manifestations occur in approximately one-half of patients with SLE and may cause substantial impairment of quality of life as well as disability. Among…

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