ACR Meeting Abstracts

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Abstracts tagged "cell modulation"

  • Abstract Number: 991 • 2018 ACR/ARHP Annual Meeting

    Critical Role of Interleukin-1α (IL-1α) in IL-1β-Induced Inflammatory Responses: Cooperation with NF-κBp65 in Transcriptional Regulation

    Anil K. Singh1, Sabrina Fechtner1, Mukesh Chourasia2, Jerry Sicalo1 and Salahuddin Ahmed1, 1Department of Pharmaceutical Sciences, Washington State University, College of Pharmacy, Spokane, WA, 2Department of Pharmacoinformatics,, National lnstitute of Pharmaceutical Education and Research, Hajipur,, India

    Background/Purpose: Interleukin-1β (IL-1β) and IL-1α are cytokines of IL-1 family that orchestrate acute and chronic inflammatory diseases. However, their distinct role or the extent of…
  • Abstract Number: 2767 • 2015 ACR/ARHP Annual Meeting

    Comparative Analysis of Drug Effects on Primary Human Coronary Artery Endothelial Cells Activated By Serum Amyloid a

    Katja Lakota1, Dolores Hrušovar2, Katjusa Mrak-Poljšak3, Polona Žigon1, Saša Čučnik1,2, Borut BožiÄ�2,3, Matija Tomšič1 and Snezna Sodin Semrl1,4, 1Department of Rheumatology, University Medical Centre Ljubljana, Ljubljana, Slovenia, 2Faculty of Pharmacy, University of Ljubljana, Ljubljana, Slovenia, 3University Medical Centre Ljubljana, Ljubljana, Slovenia, 4Faculty of Mathematics, Natural Science and Information Technology, University of Primorska, Koper, Slovenia

     Background/Purpose: In certain chronic diseases, such as rheumatoid arthritis (RA), atherosclerosis is more prevalent. RA patients have a higher incidence of cardiovascular disease and at…
  • Abstract Number: 1855 • 2015 ACR/ARHP Annual Meeting

    Systemic Lupus Erythematosus Exosomes Contain Distinct RNA Transcripts That Differentiate Disease Activity and Modulate Cellular Function

    Samantha Slight-Webb1, Krista M. Bean1, Nicolas Dominguez1, Mikhail G. Dozmorov2, Judith A. James3 and Joel M. Guthridge1, 1Arthritis and Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK, 2Arthritis and Clincial Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, 3Arthritis & Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK

    Background/Purpose: Systemic lupus erythematosus (SLE) is a complex autoimmune disease involving multiple organ systems and periods of waxing and waning disease activity. The lack of…
  • Abstract Number: 783 • 2014 ACR/ARHP Annual Meeting

    Increased Migration and Proliferation Potential Characterize Vascular Smooth Muscle Cells from Patients with Giant Cell Arteritis

    Alexis Regent1,2, Kim-Heang Ly3, Matthieu Groh2, Chabha Khifer4, Sebastien Lofek4, Guilhem Clary5, Philippe Chafey5, Cédric Broussard5, Christian Federici5, Claire Le Jeunne2, Elisabeth Vidal6, Antoine Brezin7, Veronique witko-Sarsat5, Loïc Guillevin2 and Luc Mouthon2, 1Internal Medicine, Institut Cochin, INSERM U1016, CNRS UMR 8104, Université Paris Descartes, Paris, France, Paris, France, 2National Referral Center for Rare Systemic Autoimmune Diseases, Hôpital Cochin, AP–HP, Université Paris Descartes, Paris, Paris, France, 3Laboratoire d’immunologie, EA3842, Faculté de médecine, Limoges;, Limoges, France, 4Institut Cochin, INSERM U1016, CNRS UMR 8104, Université Paris Descartes, Paris, France, Paris, France, 5Institut Cochin, INSERM U1016, CNRS UMR 8104, Université Paris Descartes, Paris, France, 6Laboratoire d’immunologie, EA3842, Faculté de médecine, Limoges, France, 7Service d’ophtalmologie, hôpital Cochin, AP-HP, Paris, France

    Background/Purpose The pathophysiology of GCA is poorly understood. Questions remain regarding the mechanisms underlying vascular remodeling. Methods Vascular smooth muscle cells (VSMC) were cultured from…
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