Abstracts tagged "cell modulation"

Abstract Number: 991 • 2018 ACR/ARHP Annual Meeting
Critical Role of Interleukin-1α (IL-1α) in IL-1β-Induced Inflammatory Responses: Cooperation with NF-κBp65 in Transcriptional Regulation
Anil K. Singh¹, Sabrina Fechtner¹, Mukesh Chourasia², Jerry Sicalo¹ and Salahuddin Ahmed¹, ¹Department of Pharmaceutical Sciences, Washington State University, College of Pharmacy, Spokane, WA, ²Department of Pharmacoinformatics,, National lnstitute of Pharmaceutical Education and Research, Hajipur,, India
Background/Purpose: Interleukin-1β (IL-1β) and IL-1α are cytokines of IL-1 family that orchestrate acute and chronic inflammatory diseases. However, their distinct role or the extent of…
Abstract Number: 1855 • 2015 ACR/ARHP Annual Meeting
Systemic Lupus Erythematosus Exosomes Contain Distinct RNA Transcripts That Differentiate Disease Activity and Modulate Cellular Function
Samantha Slight-Webb¹, Krista M. Bean¹, Nicolas Dominguez¹, Mikhail G. Dozmorov², Judith A. James³ and Joel M. Guthridge¹, ¹Arthritis and Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK, ²Arthritis and Clincial Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, ³Arthritis & Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK
Background/Purpose: Systemic lupus erythematosus (SLE) is a complex autoimmune disease involving multiple organ systems and periods of waxing and waning disease activity. The lack of…
Abstract Number: 2767 • 2015 ACR/ARHP Annual Meeting
Comparative Analysis of Drug Effects on Primary Human Coronary Artery Endothelial Cells Activated By Serum Amyloid a
Katja Lakota¹, Dolores Hrušovar², Katjusa Mrak-Poljšak³, Polona Žigon¹, SaÂša Čučnik^1,2, Borut BoÂžiÄ�^2,3, Matija Tomšič¹ and Snezna Sodin Semrl^1,4, ¹Department of Rheumatology, University Medical Centre Ljubljana, Ljubljana, Slovenia, ²Faculty of Pharmacy, University of Ljubljana, Ljubljana, Slovenia, ³University Medical Centre Ljubljana, Ljubljana, Slovenia, ⁴Faculty of Mathematics, Natural Science and Information Technology, University of Primorska, Koper, Slovenia
Background/Purpose: In certain chronic diseases, such as rheumatoid arthritis (RA), atherosclerosis is more prevalent. RA patients have a higher incidence of cardiovascular disease and at…
Abstract Number: 783 • 2014 ACR/ARHP Annual Meeting
Increased Migration and Proliferation Potential Characterize Vascular Smooth Muscle Cells from Patients with Giant Cell Arteritis
Alexis Regent^1,2, Kim-Heang Ly³, Matthieu Groh², Chabha Khifer⁴, Sebastien Lofek⁴, Guilhem Clary⁵, Philippe Chafey⁵, Cédric Broussard⁵, Christian Federici⁵, Claire Le Jeunne², Elisabeth Vidal⁶, Antoine Brezin⁷, Veronique witko-Sarsat⁵, Loïc Guillevin² and Luc Mouthon², ¹Internal Medicine, Institut Cochin, INSERM U1016, CNRS UMR 8104, Université Paris Descartes, Paris, France, Paris, France, ²National Referral Center for Rare Systemic Autoimmune Diseases, Hôpital Cochin, AP–HP, Université Paris Descartes, Paris, Paris, France, ³Laboratoire d’immunologie, EA3842, Faculté de médecine, Limoges;, Limoges, France, ⁴Institut Cochin, INSERM U1016, CNRS UMR 8104, Université Paris Descartes, Paris, France, Paris, France, ⁵Institut Cochin, INSERM U1016, CNRS UMR 8104, Université Paris Descartes, Paris, France, ⁶Laboratoire d’immunologie, EA3842, Faculté de médecine, Limoges, France, ⁷Service d’ophtalmologie, hôpital Cochin, AP-HP, Paris, France
Background/Purpose The pathophysiology of GCA is poorly understood. Questions remain regarding the mechanisms underlying vascular remodeling. Methods Vascular smooth muscle cells (VSMC) were cultured from…

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