Abstract Number: 1999 • 2018 ACR/ARHP Annual Meeting
Aberrant Expression of the GluN2B N-Methyl D-Aspartate Receptor Subunit in Osteoarthritic Chondrocytes Causes Disease-Associated Changes in Chondrocyte Phenotype through Altered Expression of Core Components of the Chondrocyte Circadian Clock
Background/Purpose: Circadian clocks are key regulators of cell behaviour. Disruption to cell clocks is implicated in a range of diseases. Expression of two core clock…Abstract Number: 2000 • 2018 ACR/ARHP Annual Meeting
Interleukin-1β, Oxidative Stress and Basic Calcium Phosphate Crystals Induce Osteoarthritis-like Changes in Chondrocyte Phenotype By Altering the Expression of PERIOD2, a Core Component of the Chondrocyte Circadian Clock
Background/Purpose: Almost all cells contain a circadian clock. Cell clocks are key regulators of cell activity and cell differentiation. In osteoarthritis (OA), chondrocytes inappropriately undergo…Abstract Number: 2157 • 2016 ACR/ARHP Annual Meeting
Share the Fate: Fibroblast-like Synoviocyte Cell-to-Cell Organelle Transfer Is Directed By the Inflammatory Microenvironment
Background/Purpose: Fibroblast-like synoviocytes (FLS) form a complex tissue network via long-distance intercellular connections with wide intercellular matrix spaces. The adaptive synovial tissue response to inflammation…Abstract Number: 2776 • 2015 ACR/ARHP Annual Meeting
Profiling Compounds in Human Primary Cell-Based Disease Models Guide Indication Selection
Background/Purpose: In vitro co-cultures of human primary cells, including immune cells, fibroblasts, smooth muscle, keratinocytes, epithelial or endothelial cells were developed to capture the complexity…Abstract Number: 1003 • 2014 ACR/ARHP Annual Meeting
Proteomic Analysis of Connexin 43 Reveals Novel Interactors Related to Osteoarthritis
Background/Purpose: We have previously reported that articular chondrocytes in tissue contain long cytoplasmic arms that physically connect two distant cells. Cell-to-cell communication occurs through connexin…Abstract Number: 783 • 2014 ACR/ARHP Annual Meeting
Increased Migration and Proliferation Potential Characterize Vascular Smooth Muscle Cells from Patients with Giant Cell Arteritis
Background/Purpose The pathophysiology of GCA is poorly understood. Questions remain regarding the mechanisms underlying vascular remodeling. Methods Vascular smooth muscle cells (VSMC) were cultured from…Abstract Number: 751 • 2014 ACR/ARHP Annual Meeting
Dissecting the Heterogeneity of Skin Gene Expression Patterns in Systemic Sclerosis
Background/Purpose: To examine the heterogeneity of global transcriptome patterns in systemic sclerosis (SSc) skin from a large cohort of patients and controls. Methods: Skin biopsies…Abstract Number: 2794 • 2014 ACR/ARHP Annual Meeting
Deletion of the Inhibitory Receptor Motif, ITIM, on DC-STAMP Alters Osteoclast Differentiation and Function
Background/Purpose DC-STAMP (Dendritic Cell-Specific Transmembrane Protein), a 7-pass transmembrane protein essential for cell-to-cell fusion during osteoclast (OC) differentiation, is expressed on the cell surface of…Abstract Number: 69 • 2013 ACR/ARHP Annual Meeting
Interconnected Cellular Projections and Gap Junctions Mediate Metabolic Coupling Between Chondrocytes Located In Different Layers Of The Tissue: Cell-To-Cell Communication In Normal and Osteoarthritic Cartilage
Background/Purpose: We have recently found that articular chondrocytes from human adults contain long cytoplasmic arms that cross the extracellular matrix and physically connect two chondrocytes…Abstract Number: 1859 • 2013 ACR/ARHP Annual Meeting
OX40+ T Cells and OX40L+ B Cells Accumulate In The Inflamed Joints and OX40 Signalling Is Skewed Towards Autoreactivity
Background/Purpose: Rheumatoid arthritis (RA) is an autoimmune disease characterized by the presence of autoantibodies and autoreactive T cells, leading to synovitis and joint destruction. The…Abstract Number: 668 • 2013 ACR/ARHP Annual Meeting
Enhanced Expression Of The Cold-Sensing Receptor-TRPM8 In Scleroderma Endothelial Cells and Skin and Endothelial Dysfunction Following TRPM8 Activation
Background/Purpose: Cold exposure induces vasospasm and incites reperfusion injury in SSc. The mechanisms responsible for enhanced cold sensitivity in SSc are poorly understood. Transient receptor…Abstract Number: 1441 • 2012 ACR/ARHP Annual Meeting
Epstein Barr Virus CD40 Functional Mimic Latent Membrane Protein-1 Drives Cellular Molecular Mimicry in the Presence of Epstein Barr Virus Nuclear Antigen-1 in a Novel Murine Model of Lupus-Like Disease
Background/Purpose: Immune dysregulation underlies the complex pathogenesis of SLE. Infection with Epstein Barr Virus (EBV) and expression of latent protein Epstein Barr Virus Nuclear Antigen-1…Abstract Number: 1151 • 2012 ACR/ARHP Annual Meeting
Low-Dose Methotrexate and the Selective Accumulation of Intracellular Aminoimidazolecarboxamide Ribotide
Background/Purpose: Current evidence suggests that the anti-folate methotrexate (MTX) mediates its anti-inflammatory effects through inhibition of the purine synthesis pathway causing the accumulation of…Abstract Number: 23 • 2012 ACR/ARHP Annual Meeting
Differential Effects of Bone Morphogenetic Protein 2 and 9 On Chondroprotective Transforming Growth Factor β Signaling
Background/Purpose: Osteoarthritis (OA) is a multifactorial disease characterized by loss of articular cartilage. TGFβ is considered as a protective factor against cartilage loss in young cartilage…• 2012 ACR/ARHP Annual Meeting
Lee C. Howley Sr. Prize for Arthritis Research Introductory Talk I
ACR Meeting Abstracts