Abstracts tagged "cell biology and methotrexate (MTX)"

Abstract Number: 2261 • 2016 ACR/ARHP Annual Meeting
Methotrexate Inhibits Intracellular Redox Signaling Induced By the Reactive Oxygen Species; Malondialdehyde and Acetaldehyde
Andrew Chiou¹, Michael J. Duryee^1,2, Cleofes Sarmiento³, Matthew Zimmerman⁴, Carlos D. Hunter¹, Lynell W. Klassen⁵, James R. O'Dell⁵, Daniel R. Anderson³, Geoffrey M. Thiele³ and Ted R Mikuls⁶, ¹Internal Medicine Division of Rheumatology, University of Nebraska Medical Center, Omaha, NE, ²Research Services, Omaha VA Medical Center, Omaha, NE, ³University of Nebraska Medical Center, Omaha, NE, ⁴Cell Biology and Physiology, University of Nebraska Medical Center, Omaha, NE, ⁵Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE, ⁶Internal Medicine, Division of Rheumatology, University of Nebraska Medical Center, Omaha, NE
Background/Purpose: Inflammatory diseases such as rheumatoid arthritis (RA) are associated with oxidative stress as a result of elevated levels of reactive oxygen species (ROS). Oxidative…

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